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A9M3J0

- PNP_NEIM0

UniProt

A9M3J0 - PNP_NEIM0

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, NMCC_0722
Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi487 – 4871Magnesium By similarity
Metal bindingi493 – 4931Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:NMCC_0722
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000087994Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374833.NMCC_0722.

Structurei

3D structure databases

ProteinModelPortaliA9M3J0.
SMRiA9M3J0. Positions 617-692.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KHAdd
BLAST
Domaini622 – 69271S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9M3J0-1 [UniParc]FASTAAdd to Basket

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MFDKHVKTFQ YGNHTVTLET GEIARQAAAA VKVSMGDTVV LVAVTTNKEV    50
KEGQDFFPLT VDYLERTYAA GKIPGGFFKR EGKQSEKEIL TSRLIDRPIR 100
PLFPEGFYHD IQIVAMVVSV DPEIDSDIPA MLGASAALVL SGVPFAGPIG 150
AARVGYINGV YVLNPTKAEL AKSQLDLVVA GTSKAVLMVE SEAKILPEDV 200
MLGAVVYGHD QMQAAINAIN EFADEVNPEV WDWKAPETNE ELVAKVRGIA 250
GETIKEAFKI RQKQARSAKL DEAWNAVKEA LITEETDTLA ANEIKGIFKH 300
LEADVVRSQI LDGQPRIDGR DTRTVRPLNI QTGVLPRTHG SALFTRGETQ 350
ALAVATLGTS RDEQIIDALS GEYTDRFMLH YNFPPYSTGE VGRVGAPKRR 400
EIGHGRLAKR ALLAVLPKPE DFSYTMRVVS EITESNGSSS MASVCGGCLS 450
LLSAGVPLKA HVAGIAMGLI LEGNKFAVLT DILGDEDHLG DMDFKVAGTT 500
EGVTALQMDI KIQGITKEIM QIALAQAKEA RLHILDQMKA AVAGPQELSA 550
HAPRLFTMKI NQDKIREVIG KGGETIRSIT AETGTEINIA EDGTITIAAT 600
TQEAGDAAKK RIEQITAEVE VGKVYEGTVV KILDNNVGAI VSVMPGKDGL 650
VHISQIAHER VRNVGDYLQV GQVVNVKALE VDDRGRVRLS IKALLDAPAR 700
EENAAE 706
Length:706
Mass (Da):76,236
Last modified:February 5, 2008 - v1
Checksum:iD3D424D13FA16D3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX72915.1.
RefSeqiYP_001598869.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX72915; ABX72915; NMCC_0722.
GeneIDi5795721.
KEGGinmn:NMCC_0722.
PATRICi20345887. VBINeiMen117761_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX72915.1 .
RefSeqi YP_001598869.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M3J0.
SMRi A9M3J0. Positions 617-692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_0722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX72915 ; ABX72915 ; NMCC_0722 .
GeneIDi 5795721.
KEGGi nmn:NMCC_0722.
PATRICi 20345887. VBINeiMen117761_0866.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci NMEN374833:GJ7Z-720-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiPNP_NEIM0
AccessioniPrimary (citable) accession number: A9M3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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