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A9M1Z4

- NAGZ_NEIM0

UniProt

A9M1Z4 - NAGZ_NEIM0

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Protein

Beta-hexosaminidase

Gene
nagZ, NMCC_0468
Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691Substrate By similarity
Binding sitei77 – 771Substrate By similarity
Binding sitei144 – 1441Substrate By similarity
Sitei185 – 1851Important for catalytic activity By similarity
Active sitei187 – 1871Proton donor/acceptor By similarity
Active sitei258 – 2581Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-466-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:NMCC_0468
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Beta-hexosaminidaseUniRule annotationPRO_1000079576Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374833.NMCC_0468.

Structurei

3D structure databases

ProteinModelPortaliA9M1Z4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 1752Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiHGVFSAI.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9M1Z4-1 [UniParc]FASTAAdd to Basket

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MTVPCIPRGL VMADIAAFRL TEEEKQRLLD PAVGGVILFR RNFQNIAQLK    50
ELTAEIKALR TPELIIAVDH EGGRVQRFIE GFTRLPAMST LGEIWDKDGA 100
SAAETAAGQV GRVLATELSA CGIDLSFTPV LDLDWGNCPV IGNRSFHRNP 150
EAVARLALAL QKGLEKGGMK SCGKHFPGHG FVEGDSHLVL PEDGRSLSEL 200
EAADLAPFRI MSREGMAAVM PAHVVYPQVD TKPAGFSEIW LKQILRRDIG 250
FKGVIFSDDL TMEGACGAGG IKERARISFE AGCDIVLVCN RPDLVDELRE 300
DFRIPDNPAL AQRWQYMANT LGSAAAQAVM QTTDFQAAQA FVAGLASPQD 350
TAGGVKVGEA F 361
Length:361
Mass (Da):38,960
Last modified:February 5, 2008 - v1
Checksum:iD1297D874BA81921
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX72669.1.
RefSeqiWP_012221334.1. NC_010120.1.
YP_001598623.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX72669; ABX72669; NMCC_0468.
GeneIDi5795592.
KEGGinmn:NMCC_0468.
PATRICi20345290. VBINeiMen117761_0571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX72669.1 .
RefSeqi WP_012221334.1. NC_010120.1.
YP_001598623.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M1Z4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_0468.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX72669 ; ABX72669 ; NMCC_0468 .
GeneIDi 5795592.
KEGGi nmn:NMCC_0468.
PATRICi 20345290. VBINeiMen117761_0571.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi HGVFSAI.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci NMEN374833:GJ7Z-466-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiNAGZ_NEIM0
AccessioniPrimary (citable) accession number: A9M1Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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