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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN374833:G1G6L-1855-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:NMCC_1587
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000001177 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832101 – 950Glycine dehydrogenase (decarboxylating)Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei698N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA9M1P7

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9M1P7
SMRiA9M1P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL

Family and domain databases

Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A9M1P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSELFNPD EFAARHLSFG DEAALLAAVG EKSMDDFVGN TVPQSIRMPS
60 70 80 90 100
ELDLPEALTE ADALAKLKGI ASKNMINKSY IGLGYYPTRV PNVILRNVLE
110 120 130 140 150
NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA
160 170 180 190 200
AEAMAMAHRV GKVKSERFFV DARVYPQTLD VMKTRAKYFG FELVVGDFAQ
210 220 230 240 250
ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVS ADIMSLVLLK
260 270 280 290 300
SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK
310 320 330 340 350
DASGKPALRM ALSTREQHIR REKATSNICT AQALLANLAG MYAVYHGPEG
360 370 380 390 400
VKRIANRIHA LASAFADALV SDGINVVHKV FFDTVTVDFG NKEKADQVFA
410 420 430 440 450
AALESGYNLR RVNDTQVAAA FHETSACEDL VDLYRAFTGK DTFAFADDVK
460 470 480 490 500
GRLNAELLRQ DDILQHPVFN RYHTEHEMLR YLKKLEDRDL AMNRSMISLG
510 520 530 540 550
SCTMKLNATA EMLPITWAEF SDIHPYAPEA QTAGYRELLA DMENSLKSIT
560 570 580 590 600
GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAQRNICLI PKSAHGTNPA
610 620 630 640 650
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY
660 670 680 690 700
EEGIRDICRI VHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF
710 720 730 740 750
CIPHGGGGPG MGPIGLKAHL APFAPGHALT DTHSASADQT AVAAAAFGSA
760 770 780 790 800
SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR
810 820 830 840 850
VAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT
860 870 880 890 900
ESESKAELDR FIAALKQIKQ EVLKVGRGEW PKEDNPLVNA PHTASDVTGE
910 920 930 940 950
WAHPYSREEA VFPLPFVREH KFWPSVNRVD DVYGDRNLVC SCPPMENYED
Length:950
Mass (Da):103,931
Last modified:February 5, 2008 - v1
Checksum:i7D95ED0037B62BC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA Translation: ABX73736.1
RefSeqiWP_002258673.1, NC_010120.1

Genome annotation databases

EnsemblBacteriaiABX73736; ABX73736; NMCC_1587
KEGGinmn:NMCC_1587

Similar proteinsi

Entry informationi

Entry nameiGCSP_NEIM0
AccessioniPrimary (citable) accession number: A9M1P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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