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A9M1P7

- GCSP_NEIM0

UniProt

A9M1P7 - GCSP_NEIM0

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNMEN374833:GJ7Z-1584-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:NMCC_1587
    OrganismiNeisseria meningitidis serogroup C (strain 053442)
    Taxonomic identifieri374833 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000001177: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Glycine dehydrogenase (decarboxylating)PRO_1000083210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei698 – 6981N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi374833.NMCC_1587.

    Structurei

    3D structure databases

    ProteinModelPortaliA9M1P7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9M1P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLSELFNPD EFAARHLSFG DEAALLAAVG EKSMDDFVGN TVPQSIRMPS    50
    ELDLPEALTE ADALAKLKGI ASKNMINKSY IGLGYYPTRV PNVILRNVLE 100
    NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA 150
    AEAMAMAHRV GKVKSERFFV DARVYPQTLD VMKTRAKYFG FELVVGDFAQ 200
    ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVS ADIMSLVLLK 250
    SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK 300
    DASGKPALRM ALSTREQHIR REKATSNICT AQALLANLAG MYAVYHGPEG 350
    VKRIANRIHA LASAFADALV SDGINVVHKV FFDTVTVDFG NKEKADQVFA 400
    AALESGYNLR RVNDTQVAAA FHETSACEDL VDLYRAFTGK DTFAFADDVK 450
    GRLNAELLRQ DDILQHPVFN RYHTEHEMLR YLKKLEDRDL AMNRSMISLG 500
    SCTMKLNATA EMLPITWAEF SDIHPYAPEA QTAGYRELLA DMENSLKSIT 550
    GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAQRNICLI PKSAHGTNPA 600
    TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY 650
    EEGIRDICRI VHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF 700
    CIPHGGGGPG MGPIGLKAHL APFAPGHALT DTHSASADQT AVAAAAFGSA 750
    SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR 800
    VAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
    ESESKAELDR FIAALKQIKQ EVLKVGRGEW PKEDNPLVNA PHTASDVTGE 900
    WAHPYSREEA VFPLPFVREH KFWPSVNRVD DVYGDRNLVC SCPPMENYED 950
    Length:950
    Mass (Da):103,931
    Last modified:February 5, 2008 - v1
    Checksum:i7D95ED0037B62BC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX73736.1.
    RefSeqiYP_001599695.1. NC_010120.1.

    Genome annotation databases

    EnsemblBacteriaiABX73736; ABX73736; NMCC_1587.
    GeneIDi5796524.
    KEGGinmn:NMCC_1587.
    PATRICi20348101. VBINeiMen117761_1956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX73736.1 .
    RefSeqi YP_001599695.1. NC_010120.1.

    3D structure databases

    ProteinModelPortali A9M1P7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374833.NMCC_1587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX73736 ; ABX73736 ; NMCC_1587 .
    GeneIDi 5796524.
    KEGGi nmn:NMCC_1587.
    PATRICi 20348101. VBINeiMen117761_1956.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci NMEN374833:GJ7Z-1584-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
      Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
      Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 053442.

    Entry informationi

    Entry nameiGCSP_NEIM0
    AccessioniPrimary (citable) accession number: A9M1P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3