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A9M1P7

- GCSP_NEIM0

UniProt

A9M1P7 - GCSP_NEIM0

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, NMCC_1587
Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-1584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NMCC_1587
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000083210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei698 – 6981N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi374833.NMCC_1587.

Structurei

3D structure databases

ProteinModelPortaliA9M1P7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9M1P7-1 [UniParc]FASTAAdd to Basket

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MKLSELFNPD EFAARHLSFG DEAALLAAVG EKSMDDFVGN TVPQSIRMPS    50
ELDLPEALTE ADALAKLKGI ASKNMINKSY IGLGYYPTRV PNVILRNVLE 100
NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA 150
AEAMAMAHRV GKVKSERFFV DARVYPQTLD VMKTRAKYFG FELVVGDFAQ 200
ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVS ADIMSLVLLK 250
SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK 300
DASGKPALRM ALSTREQHIR REKATSNICT AQALLANLAG MYAVYHGPEG 350
VKRIANRIHA LASAFADALV SDGINVVHKV FFDTVTVDFG NKEKADQVFA 400
AALESGYNLR RVNDTQVAAA FHETSACEDL VDLYRAFTGK DTFAFADDVK 450
GRLNAELLRQ DDILQHPVFN RYHTEHEMLR YLKKLEDRDL AMNRSMISLG 500
SCTMKLNATA EMLPITWAEF SDIHPYAPEA QTAGYRELLA DMENSLKSIT 550
GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAQRNICLI PKSAHGTNPA 600
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY 650
EEGIRDICRI VHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF 700
CIPHGGGGPG MGPIGLKAHL APFAPGHALT DTHSASADQT AVAAAAFGSA 750
SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR 800
VAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
ESESKAELDR FIAALKQIKQ EVLKVGRGEW PKEDNPLVNA PHTASDVTGE 900
WAHPYSREEA VFPLPFVREH KFWPSVNRVD DVYGDRNLVC SCPPMENYED 950
Length:950
Mass (Da):103,931
Last modified:February 5, 2008 - v1
Checksum:i7D95ED0037B62BC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX73736.1.
RefSeqiYP_001599695.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX73736; ABX73736; NMCC_1587.
GeneIDi5796524.
KEGGinmn:NMCC_1587.
PATRICi20348101. VBINeiMen117761_1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX73736.1 .
RefSeqi YP_001599695.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M1P7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_1587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX73736 ; ABX73736 ; NMCC_1587 .
GeneIDi 5796524.
KEGGi nmn:NMCC_1587.
PATRICi 20348101. VBINeiMen117761_1956.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NMEN374833:GJ7Z-1584-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiGCSP_NEIM0
AccessioniPrimary (citable) accession number: A9M1P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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