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A9M1P7

- GCSP_NEIM0

UniProt

A9M1P7 - GCSP_NEIM0

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-1584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:NMCC_1587
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)PRO_1000083210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei698 – 6981N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi374833.NMCC_1587.

Structurei

3D structure databases

ProteinModelPortaliA9M1P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9M1P7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSELFNPD EFAARHLSFG DEAALLAAVG EKSMDDFVGN TVPQSIRMPS
60 70 80 90 100
ELDLPEALTE ADALAKLKGI ASKNMINKSY IGLGYYPTRV PNVILRNVLE
110 120 130 140 150
NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA
160 170 180 190 200
AEAMAMAHRV GKVKSERFFV DARVYPQTLD VMKTRAKYFG FELVVGDFAQ
210 220 230 240 250
ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVS ADIMSLVLLK
260 270 280 290 300
SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK
310 320 330 340 350
DASGKPALRM ALSTREQHIR REKATSNICT AQALLANLAG MYAVYHGPEG
360 370 380 390 400
VKRIANRIHA LASAFADALV SDGINVVHKV FFDTVTVDFG NKEKADQVFA
410 420 430 440 450
AALESGYNLR RVNDTQVAAA FHETSACEDL VDLYRAFTGK DTFAFADDVK
460 470 480 490 500
GRLNAELLRQ DDILQHPVFN RYHTEHEMLR YLKKLEDRDL AMNRSMISLG
510 520 530 540 550
SCTMKLNATA EMLPITWAEF SDIHPYAPEA QTAGYRELLA DMENSLKSIT
560 570 580 590 600
GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAQRNICLI PKSAHGTNPA
610 620 630 640 650
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY
660 670 680 690 700
EEGIRDICRI VHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF
710 720 730 740 750
CIPHGGGGPG MGPIGLKAHL APFAPGHALT DTHSASADQT AVAAAAFGSA
760 770 780 790 800
SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR
810 820 830 840 850
VAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT
860 870 880 890 900
ESESKAELDR FIAALKQIKQ EVLKVGRGEW PKEDNPLVNA PHTASDVTGE
910 920 930 940 950
WAHPYSREEA VFPLPFVREH KFWPSVNRVD DVYGDRNLVC SCPPMENYED
Length:950
Mass (Da):103,931
Last modified:February 5, 2008 - v1
Checksum:i7D95ED0037B62BC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX73736.1.
RefSeqiYP_001599695.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX73736; ABX73736; NMCC_1587.
GeneIDi5796524.
KEGGinmn:NMCC_1587.
PATRICi20348101. VBINeiMen117761_1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX73736.1 .
RefSeqi YP_001599695.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M1P7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_1587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX73736 ; ABX73736 ; NMCC_1587 .
GeneIDi 5796524.
KEGGi nmn:NMCC_1587.
PATRICi 20348101. VBINeiMen117761_1956.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NMEN374833:GJ7Z-1584-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiGCSP_NEIM0
AccessioniPrimary (citable) accession number: A9M1P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3