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A9M1G6

- GSA_NEIM0

UniProt

A9M1G6 - GSA_NEIM0

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-355-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:NMCC_0357
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000079926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi374833.NMCC_0357.

Structurei

3D structure databases

ProteinModelPortaliA9M1G6.
SMRiA9M1G6. Positions 3-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRFMVSGN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9M1G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRNEILFDR AKAIIPGGVN SPVRAFGSVG GVPRFIKKAE GAYVWDENGT
60 70 80 90 100
RYTDYVGSWG PAIVGHAHPE VVEAVREAAL GGLSFGAPTE GEIAIAEQIA
110 120 130 140 150
KIMPSVERLR LVSSGTEATM TAIRLARGFT GRDKIIKFEG CYHGHSDSLL
160 170 180 190 200
VKAGSGLLTF GNPSSAGVPA DFTKHTLVLE YNNIAQLEEA FAQSGNDIAC
210 220 230 240 250
VILEPFVGNM NLVRPTEAFV KALRELTEKH GAVLIYDEVM TGFRVALGGA
260 270 280 290 300
QSLHGIMPDL TTMGKVIGGG MPLAAFGGRK DIMECISPLG GVYQAGTLSG
310 320 330 340 350
NPIAVAAGLK TLEIIRREGF YENLTARTEQ LVQGFRTAAD AAGIEFTADS
360 370 380 390 400
VGGMFGLYFA AHAPRNYADM ARSNIDAFKR FFHGMLDRGI AFGPSAYEAG
410 420
FVSAAHTPEL IDETVAVAVE VFKAMAA
Length:427
Mass (Da):45,340
Last modified:February 5, 2008 - v1
Checksum:i4018875940918482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX72564.1.
RefSeqiYP_001598518.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX72564; ABX72564; NMCC_0357.
GeneIDi5795341.
KEGGinmn:NMCC_0357.
PATRICi20344989. VBINeiMen117761_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX72564.1 .
RefSeqi YP_001598518.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M1G6.
SMRi A9M1G6. Positions 3-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_0357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX72564 ; ABX72564 ; NMCC_0357 .
GeneIDi 5795341.
KEGGi nmn:NMCC_0357.
PATRICi 20344989. VBINeiMen117761_0422.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RFMVSGN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci NMEN374833:GJ7Z-355-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiGSA_NEIM0
AccessioniPrimary (citable) accession number: A9M1G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3