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A9M0T9

- PNCB_NEIM0

UniProt

A9M0T9 - PNCB_NEIM0

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, NMCC_1410
Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-1408-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:NMCC_1410
OrganismiNeisseria meningitidis serogroup C (strain 053442)
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000001177: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000082325Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374833.NMCC_1410.

Structurei

3D structure databases

ProteinModelPortaliA9M0T9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKFTMWQA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9M0T9-1 [UniParc]FASTAAdd to Basket

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MTGIIHSLLD TDLYKFTMLQ VVLHQFPQTH SLYEFRCRNA STVYPLADIK    50
EDLEAELDAL CRLRFTHDEL GYLRSLRFIK SDFVDYLELF QLQRRFVEIG 100
TDDKDRLNIR IEGPMIQAMF FEIFILAIVN ELYFRRLETP AVIEEGERRL 150
QAKAARLKEI AAAQNPDDPP FLISDFGTRR RYKLAWQEHV IRTLLEAAPS 200
IVRGTSNVFL AKKLGITPIG TMAHEFLQAF QALDVRLRNF QKAALESWVH 250
EYRGDLGVAL TDVVGMDAFL RDFDLYFAKL FDGLRHDSGD PYVWGDKAYA 300
HYQKLKIDSR TKMLTFSDGL DIERSWALHQ YFKDRFKTGF GIGTNLTNDM 350
GHTPLNIVLK LVECNGQSVA KLSDSPGKTM TNNSTFLAYL RQVFDVPEPE 400
TP 402
Length:402
Mass (Da):46,326
Last modified:February 5, 2008 - v1
Checksum:i2EDBA294DFAB7AC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX73579.1.
RefSeqiYP_001599536.1. NC_010120.1.

Genome annotation databases

EnsemblBacteriaiABX73579; ABX73579; NMCC_1410.
GeneIDi5795438.
KEGGinmn:NMCC_1410.
PATRICi20347638. VBINeiMen117761_1734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000381 Genomic DNA. Translation: ABX73579.1 .
RefSeqi YP_001599536.1. NC_010120.1.

3D structure databases

ProteinModelPortali A9M0T9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374833.NMCC_1410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX73579 ; ABX73579 ; NMCC_1410 .
GeneIDi 5795438.
KEGGi nmn:NMCC_1410.
PATRICi 20347638. VBINeiMen117761_1734.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi KFTMWQA.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci NMEN374833:GJ7Z-1408-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442.

Entry informationi

Entry nameiPNCB_NEIM0
AccessioniPrimary (citable) accession number: A9M0T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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