Reviewed, UniProtKB/Swiss-Prot A9M0T9 (PNCB_NEIM0)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	NMCC_1410

Organism

Neisseria meningitidis serogroup C (strain 053442) [Complete proteome] [HAMAP]

Taxonomic identifier

374833 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000082325

Sequences

	Sequence		Length	Mass (Da)
	A9M0T9-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 2EDBA294DFAB7AC7	FASTA	402	46,326
	10 20 30 40 50 60 MTGIIHSLLD TDLYKFTMLQ VVLHQFPQTH SLYEFRCRNA STVYPLADIK EDLEAELDAL 70 80 90 100 110 120 CRLRFTHDEL GYLRSLRFIK SDFVDYLELF QLQRRFVEIG TDDKDRLNIR IEGPMIQAMF 130 140 150 160 170 180 FEIFILAIVN ELYFRRLETP AVIEEGERRL QAKAARLKEI AAAQNPDDPP FLISDFGTRR 190 200 210 220 230 240 RYKLAWQEHV IRTLLEAAPS IVRGTSNVFL AKKLGITPIG TMAHEFLQAF QALDVRLRNF 250 260 270 280 290 300 QKAALESWVH EYRGDLGVAL TDVVGMDAFL RDFDLYFAKL FDGLRHDSGD PYVWGDKAYA 310 320 330 340 350 360 HYQKLKIDSR TKMLTFSDGL DIERSWALHQ YFKDRFKTGF GIGTNLTNDM GHTPLNIVLK 370 380 390 400 LVECNGQSVA KLSDSPGKTM TNNSTFLAYL RQVFDVPEPE TP

References

[1]

"Characterization of ST-4821 complex, a unique Neisseria meningitidis clone." Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q. Genomics 91:78-87(2008) [PubMed: 18031983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000381 Genomic DNA. Translation: ABX73579.1.
RefSeq	YP_001599536.1.
3D structure databases
SMR	A9M0T9. Positions 3-396.
ModBase	Search...
Genome annotation databases
GeneID	5795438.
GenomeReviews	Gene locus NMCC_1410 in contig CP000381_GR.
KEGG	nmn:NMCC_1410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
OMA	LYKFTML.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_NEIM0

Accession

Primary (citable) accession number: A9M0T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	February 9, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)