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A9LZQ8

- TRMB_NEIM0

UniProt

A9LZQ8 - TRMB_NEIM0

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701S-adenosyl-L-methionineUniRule annotation
    Binding sitei95 – 951S-adenosyl-L-methionineUniRule annotation
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
    Active sitei145 – 1451By similarity
    Binding sitei145 – 1451S-adenosyl-L-methionineUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciNMEN374833:GJ7Z-1241-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:NMCC_1243
    OrganismiNeisseria meningitidis serogroup C (strain 053442)
    Taxonomic identifieri374833 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000001177: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferasePRO_1000084446Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374833.NMCC_1243.

    Structurei

    3D structure databases

    ProteinModelPortaliA9LZQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 2194Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9LZQ8-1 [UniParc]FASTAAdd to Basket

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    MTDTAENQTP NDRQAGHPRS IRSFVLRQSH MTAAQQRAID TLWDSFGIDY    50
    QATPVDLDAN FGSNRPKILE IGFGMGTATA EIALRLPETD FLAIDVHGPG 100
    VGNLLKLINE NHLENIRVMR HDAVEVVENM LQDGSLDGIH IFFPDPWHKK 150
    RHHKRRLIQA PFIAKLLPKL KTGGYIHLAT DWEEYAQQML EVLSSFDSLQ 200
    NTATDYAPTP DYRPETKFEA RGKRLGHGVW DLVFKRIR 238
    Length:238
    Mass (Da):27,076
    Last modified:February 5, 2008 - v1
    Checksum:i8D3293D7DAE2BAAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX73416.1.
    RefSeqiYP_001599373.1. NC_010120.1.

    Genome annotation databases

    EnsemblBacteriaiABX73416; ABX73416; NMCC_1243.
    GeneIDi5795062.
    KEGGinmn:NMCC_1243.
    PATRICi20347168. VBINeiMen117761_1498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000381 Genomic DNA. Translation: ABX73416.1 .
    RefSeqi YP_001599373.1. NC_010120.1.

    3D structure databases

    ProteinModelPortali A9LZQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374833.NMCC_1243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX73416 ; ABX73416 ; NMCC_1243 .
    GeneIDi 5795062.
    KEGGi nmn:NMCC_1243.
    PATRICi 20347168. VBINeiMen117761_1498.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci NMEN374833:GJ7Z-1241-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
      Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
      Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 053442.

    Entry informationi

    Entry nameiTRMB_NEIM0
    AccessioniPrimary (citable) accession number: A9LZQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3