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A9LZI3 (PGK_NEIM0) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:NMCC_0010
OrganismNeisseria meningitidis serogroup C (strain 053442) [Complete proteome] [HAMAP]
Taxonomic identifier374833 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000076595

Regions

Nucleotide binding346 – 3494ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1141Substrate By similarity
Binding site1471Substrate By similarity
Binding site1981ATP By similarity
Binding site3201ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9LZI3 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 7F4E597870BCE837

FASTA39240,734
        10         20         30         40         50         60 
MAFLKLTEQN VQGKTVLIRA DMNVPFKDGK ISDDTRIRAS LASVKYCLDN GASVIVMTHL 

        70         80         90        100        110        120 
GRPTEGEFHP EDDVAPVAAH LGGLLGKDVK VLNDWRENKP ALNAGDVVML QNVRINKGEK 

       130        140        150        160        170        180 
KNDLELGKAY ASLCDVFVND AFGTAHRAQA STEAVAQAAP VACAGVLMAG ELDALGKALK 

       190        200        210        220        230        240 
QPARPMVAIV AGSKVSTKLT ILESLADKVD QLIVGGGIAN TFLLAEGKAI GKSLAEHDLV 

       250        260        270        280        290        300 
EESKKIMAKM AAKGGSVPLP TDVVVAKAFA ADAEAVVKDI ADVAEDEMIL DIGPKSAAAL 

       310        320        330        340        350        360 
ADLLKAADTV VWNGPVGVFE FDQFAGGTKA LTEAIAQSKA FSIAGGGDTL AAIAKFGVTD 

       370        380        390 
QIGYISTGGG AFLEFLEGKE LPAVAALEKR GE 

« Hide

References

[1]"Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 053442.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000381 Genomic DNA. Translation: ABX72241.1.
RefSeqYP_001598194.1. NC_010120.1.

3D structure databases

ProteinModelPortalA9LZI3.
SMRA9LZI3. Positions 3-392.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING374833.NMCC_0010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX72241; ABX72241; NMCC_0010.
GeneID5795013.
KEGGnmn:NMCC_0010.
PATRIC20344140. VBINeiMen117761_0011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycNMEN374833:GJ7Z-10-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_NEIM0
AccessionPrimary (citable) accession number: A9LZI3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways