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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-1164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyaseUniRule annotation (EC:4.3.1.1UniRule annotation)
Short name:
AspartaseUniRule annotation
Gene namesi
Name:aspAImported
Ordered Locus Names:NMCC_1166Imported
OrganismiNeisseria meningitidis serogroup C (strain 053442)Imported
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000001177 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA9LZG4.
SMRiA9LZG4. Positions 19-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 359332Lyase_1InterPro annotationAdd
BLAST
Domaini425 – 47753FumaraseC_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9LZG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHFFNINYP TYKGKNMTVR IEHDLLGDRE IPAEVYWGIH TLRAIENFKI
60 70 80 90 100
STQKISDVPQ FVRSMVMVKK ATAQANGELG AVKPEIAAAI EKACDEVLLN
110 120 130 140 150
NRCLDQFPSD VYQGGAGTSV NMNTNEVIAN LALEALGYEK GRYDIVNPMD
160 170 180 190 200
HVNASQSTND AYPTGFRLAV YYSIGELLDK LTVLKNAFTA KAEEFKDVLK
210 220 230 240 250
MGRTQLQDAV PMTAGQEFQS FQVLLEEEIL NLDRTRQLLL EVNLGATAIG
260 270 280 290 300
TGVNTPKGYA ELVVKKLSEV SGLPCKLTEN LIEATSDCGA YVMVHGALKR
310 320 330 340 350
TAVKLSKICN DLRLLSSGPR AGLKEINLPE LQAGSSIMPA KVNPVIPEVV
360 370 380 390 400
NQVCFKVIGN DTTITFAAEA GQLQLNVMEP VIAQCMFETI SLLGNAAINL
410 420 430 440 450
SDKCVKGITV NREICERYVF NSIGLVTYLN PYIGHHNGDL VGKICAQTGK
460 470 480
GVREVVLERG LLSEEELNRI LSPENLMNPH L
Length:481
Mass (Da):52,705
Last modified:February 5, 2008 - v1
Checksum:i978B84499A781059
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX73340.1.

Genome annotation databases

EnsemblBacteriaiABX73340; ABX73340; NMCC_1166.
KEGGinmn:NMCC_1166.
PATRICi20346984. VBINeiMen117761_1407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA. Translation: ABX73340.1.

3D structure databases

ProteinModelPortaliA9LZG4.
SMRiA9LZG4. Positions 19-472.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX73340; ABX73340; NMCC_1166.
KEGGinmn:NMCC_1166.
PATRICi20346984. VBINeiMen117761_1407.

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Enzyme and pathway databases

BioCyciNMEN374833:GJ7Z-1164-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of ST-4821 complex, a unique Neisseria meningitidis clone."
    Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q.
    Genomics 91:78-87(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 053442Imported.

Entry informationi

Entry nameiA9LZG4_NEIM0
AccessioniPrimary (citable) accession number: A9LZG4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 17, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.