A9LZ86 (GLND_NEIM0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Protein-PII] uridylyltransferase
Short name=PII uridylyl-transferase
EC=2.7.7.59

Alternative name(s):
UTase
Uridylyl-removing enzyme

Gene names

Name:	glnD
Ordered Locus Names:	NMCC_1086

Organism

Neisseria meningitidis serogroup C (strain 053442) [Complete proteome] [HAMAP]

Taxonomic identifier

374833 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein By similarity. HAMAP MF_00277
Catalytic activity	UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP MF_00277
Sequence similarities	Belongs to the glnD family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	[protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: InterPro phosphoric diester hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 852	852	[Protein-PII] uridylyltransferase HAMAP MF_00277		PRO_1000078806

Sequences

	Sequence		Length	Mass (Da)
	A9LZ86 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 6E3897F76ABFCCE0	FASTA	852	96,950
	10 20 30 40 50 60 MPANLSSALE TFKRQRDAAE AHYLKANRVS VFFREYTAAV ETLLAALWVE HFQNSALCLM 70 80 90 100 110 120 AVGGFGRGEL YPCSDVDLAV VSPAPLSDGI QEQIARFVQT LWDCKLMPSV KSGSVGELCE 130 140 150 160 170 180 SVRDDITGDT AFLEARFLFG NRQTADELAK KMNAQRNVAA FVEAKLVEME HRHAKSQGSG 190 200 210 220 230 240 AVLEPNIKSC PGGLRDIHTL LWIAKAQGLA TDLPDLLKQR ILTRAEAGML SHGYRRLAHI 250 260 270 280 290 300 RIHLHLNAKR AEDRLLFDLQ PQVAESMGYE GLNLRRQSEE LMRVFYRAIK TVKQLGGILT 310 320 330 340 350 360 PMLQSRVSST PLRVTLRIDD DYIQVNNQIA ARHTDIFFRR PEHIFKIVEI MQQRNDITAL 370 380 390 400 410 420 EPQTLRAWWG ATRKINRSFY QNSENRHRFA GFFRNGNGLT QTLRFLNLYG VLGRYLPAWE 430 440 450 460 470 480 KIVGLLQHDL FHIYPVDDHI LTVVRNVRRL ALDMHSHELP YASALMQSFE KQDILYLAAF 490 500 510 520 530 540 FHDIAKGRGG DHAIQGIADA RQFAADHFLT EEESDLLAWL VENHLLMSTV AQKEDIQDPS 550 560 570 580 590 600 VLDAFCKRVQ THERLSALYL LTISDIRGTN PKLWNAWRAS LLESLFHAAG RYLTGNGGNP 610 620 630 640 650 660 HTLFGRRRQE AADLLTRAAV PEKQQKKLWN ALGSAYFARH QSREILWHAA NLVHDFETPI 670 680 690 700 710 720 VRSRILPQSD SFQVMVFMPN GPRLFARLCR IFSRHGFDIL AARAFITEHD YILDTFIVQI 730 740 750 760 770 780 PSQHAPEDYP DIQSALEAEL NSFIHGHTVA EISSHSRRIS RRSRYMPIAP SITITPEEDY 790 800 810 820 830 840 PDWYSVEITA VNRPFLLADM AEVFFAHNVS LRYAKISTLD ERAEDSFTVF SPDLNNPKIQ 850 SSLKQTLLEQ LS

References

[1]

"Characterization of ST-4821 complex, a unique Neisseria meningitidis clone." Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z., Liang X., Xu J., Jin Q. Genomics 91:78-87(2008) [PubMed: 18031983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 053442.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000381 Genomic DNA. Translation: ABX73263.1.
RefSeq	YP_001599219.1. NC_010120.1.
3D structure databases
ProteinModelPortal	A9LZ86.
ModBase	Search...
Protein-protein interaction databases
STRING	A9LZ86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000012638; EBNEIP00000012180; EBNEIG00000012638.
GeneID	5796239.
GenomeReviews	Gene locus NMCC_1086 in contig CP000381_GR.
KEGG	nmn:NMCC_1086.
PATRIC	20346794. VBINeiMen117761_1313.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020881.
HOGENOM	HBG687872.
OMA	MQHDLFH.
ProtClustDB	CLSK877933.
Enzyme and pathway databases
BioCyc	NMEN374833:NMCC_1086-MONOMER.
Family and domain databases
HAMAP	MF_00277. PII_uridylyl-transf. [Tree]
InterPro	IPR010043. GlnD_Uridyltrans. IPR023279. HD. IPR003607. Metal-dep_PHydrolase_HD_dom. IPR006674. Metal-dep_PHydrolase_HD_sub. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
Gene3D	G3DSA:1.10.3210.10. HD. 1 hit.
KO	K00990.
PANTHER	PTHR13734:SF1. GlnD_Uridyltrans. 1 hit.
Pfam	PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. [Graphical view]
PIRSF	PIRSF006288. PII_uridyltransf. 1 hit.
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR01693. UTase_glnD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLND_NEIM0

Accession

Primary (citable) accession number: A9LZ86

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program