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A9LNM8 (A9LNM8_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
cGMP-dependent protein kinase PIRNR PIRNR000559
EC=2.7.11.12 PIRNR PIRNR000559
Gene names
Name:Prkg1 RGD 1587390
Synonyms:Pkg EMBL ABX38843.1
OrganismRattus norvegicus (Rat) EMBL ABX38843.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. PIRNR PIRNR000559 SAAS SAAS000961

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. PIRNR PIRNR000559

Contains 1 AGC-kinase C-terminal domain. SAAS SAAS000961

Sequences

Sequence LengthMass (Da)Tools
A9LNM8 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: BC6DA0DCA40B3791

FASTA67176,369
        10         20         30         40         50         60 
MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP STHIGPRTTR 

        70         80         90        100        110        120 
AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD NDFMKNLELS QIQEIVDCMY 

       130        140        150        160        170        180 
PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV TKEGVKLCTM GPGKVFGELA ILYNCTRTAT 

       190        200        210        220        230        240 
VKTLVNVKLW AIDRQCFQTI MMRTGLIKHT EYMEFLKSVP TFQSLPDEIL SKLADVLEET 

       250        260        270        280        290        300 
HYENGEYIIR QGARGDTFFI ISKGKVSVTR EDSPSEDPVF LRTLGKGDWF EEKALQGEDV 

       310        320        330        340        350        360 
RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA FFANLKLSDF 

       370        380        390        400        410        420 
NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 

       430        440        450        460        470        480 
IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 

       490        500        510        520        530        540 
IYRDLKPENL ILDHRGYAEL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 

       550        560        570        580        590        600 
YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKSAANL IKKLCRDNPS 

       610        620        630        640        650        660 
ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD SFPEDSDEPP 

       670 
PDDNSGWDID F

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References

[1]"Cyclic GMP-dependent protein kinase (PKG) regulates smooth muscle gene expression: Possible involvement of Elk-1 sumoylation."
Choi C., Brown F.M., Sellak H., Lincoln T.M.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL ABX38843.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		EU251189 mRNA. Translation: ABX38843.1.
IPIIPI00870747.
RefSeqNP_001099201.3. NM_001105731.3.
UniGeneRn.204724.

3D structure databases

ProteinModelPortalA9LNM8.
SMRA9LNM8. Positions 9-44.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000041168.
A9LNM8.

Proteomic databases

PaxDbA9LNM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54286.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233033.
HOVERGENHBG006211.

Gene expression databases

GenevestigatorA9LNM8.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSPR00104. CGMPKINASE.
SMARTSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF51206. cNMP_binding. 2 hits.
SSF56112. Kinase_like. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610872.

Entry information

Entry nameA9LNM8_RAT
AccessionPrimary (citable) accession number: A9LNM8
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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