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A9LNM8

- A9LNM8_RAT

UniProt

A9LNM8 - A9LNM8_RAT

Protein

cGMP-dependent protein kinase

Gene

Prkg1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cGMP binding Source: UniProtKB-KW
    3. cGMP-dependent protein kinase activity Source: UniProtKB-EC
    4. mitogen-activated protein kinase p38 binding Source: RGD
    5. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. cell growth involved in cardiac muscle cell development Source: RGD
    3. cerebellum development Source: RGD
    4. heart development Source: RGD
    5. negative regulation of glutamate secretion Source: RGD
    6. negative regulation of heart contraction Source: RGD
    7. negative regulation of inositol phosphate biosynthetic process Source: RGD
    8. negative regulation of smooth muscle cell migration Source: RGD
    9. positive regulation of circadian rhythm Source: RGD
    10. positive regulation of cytosolic calcium ion concentration Source: RGD
    11. positive regulation of large conductance calcium-activated potassium channel activity Source: RGD
    12. positive regulation of vasodilation Source: RGD
    13. regulation of testosterone biosynthetic process Source: RGD
    14. spermatid development Source: RGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, cGMP, cGMP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-dependent protein kinaseUniRule annotation (EC:2.7.11.12UniRule annotation)
    Gene namesi
    Name:Prkg1Imported
    Synonyms:PkgImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi1587390. Prkg1.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: RGD
    2. cytosol Source: RGD
    3. Golgi apparatus Source: RGD
    4. membrane Source: RGD
    5. nucleoplasm Source: RGD

    PTM / Processingi

    Proteomic databases

    PaxDbiA9LNM8.

    Expressioni

    Gene expression databases

    GenevestigatoriA9LNM8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000041168.

    Structurei

    3D structure databases

    ProteinModelPortaliA9LNM8.
    SMRiA9LNM8. Positions 9-44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.UniRule annotation
    Contains AGC-kinase C-terminal domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233033.
    HOVERGENiHBG006211.
    KOiK07376.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSiPR00104. CGMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9LNM8-1 [UniParc]FASTAAdd to Basket

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    MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP    50
    STHIGPRTTR AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD 100
    NDFMKNLELS QIQEIVDCMY PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV 150
    TKEGVKLCTM GPGKVFGELA ILYNCTRTAT VKTLVNVKLW AIDRQCFQTI 200
    MMRTGLIKHT EYMEFLKSVP TFQSLPDEIL SKLADVLEET HYENGEYIIR 250
    QGARGDTFFI ISKGKVSVTR EDSPSEDPVF LRTLGKGDWF EEKALQGEDV 300
    RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA 350
    FFANLKLSDF NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT 400
    RQQEHIRSEK QIMQGAHSDF IVRLYRTFKD SKYLYMLMEA CLGGELWTIL 450
    RDRGSFEDST TRFYTACVVE AFAYLHSKGI IYRDLKPENL ILDHRGYAEL 500
    VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD YWSLGILMYE 550
    LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKSAANL IKKLCRDNPS 600
    ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD 650
    SFPEDSDEPP PDDNSGWDID F 671
    Length:671
    Mass (Da):76,369
    Last modified:February 5, 2008 - v1
    Checksum:iBC6DA0DCA40B3791
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU251189 mRNA. Translation: ABX38843.1.
    RefSeqiNP_001099201.3. NM_001105731.3.
    UniGeneiRn.204724.

    Genome annotation databases

    GeneIDi54286.
    KEGGirno:54286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU251189 mRNA. Translation: ABX38843.1 .
    RefSeqi NP_001099201.3. NM_001105731.3.
    UniGenei Rn.204724.

    3D structure databases

    ProteinModelPortali A9LNM8.
    SMRi A9LNM8. Positions 9-44.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000041168.

    Proteomic databases

    PaxDbi A9LNM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54286.
    KEGGi rno:54286.

    Organism-specific databases

    CTDi 5592.
    RGDi 1587390. Prkg1.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233033.
    HOVERGENi HBG006211.
    KOi K07376.

    Miscellaneous databases

    NextBioi 610872.

    Gene expression databases

    Genevestigatori A9LNM8.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSi PR00104. CGMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cyclic GMP-dependent protein kinase (PKG) regulates smooth muscle gene expression: Possible involvement of Elk-1 sumoylation."
      Choi C., Brown F.M., Sellak H., Lincoln T.M.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiA9LNM8_RAT
    AccessioniPrimary (citable) accession number: A9LNM8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)