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A9LMQ0

- A9LMQ0_CANFA

UniProt

A9LMQ0 - A9LMQ0_CANFA

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Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. activation of MAPK activity Source: Ensembl
  3. activation of MAPKKK activity Source: Ensembl
  4. cellular response to amino acid stimulus Source: Ensembl
  5. cellular response to nicotine Source: Ensembl
  6. chronic inflammatory response to antigenic stimulus Source: Ensembl
  7. defense response to Gram-positive bacterium Source: Ensembl
  8. embryonic digestive tract development Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. extracellular matrix organization Source: Ensembl
  11. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  12. glucose metabolic process Source: Ensembl
  13. humoral immune response Source: Ensembl
  14. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  15. JNK cascade Source: Ensembl
  16. leukocyte tethering or rolling Source: Ensembl
  17. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  18. necroptotic signaling pathway Source: Ensembl
  19. negative regulation of alkaline phosphatase activity Source: Ensembl
  20. negative regulation of branching involved in lung morphogenesis Source: Ensembl
  21. negative regulation of cytokine secretion involved in immune response Source: Ensembl
  22. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  23. negative regulation of glucose import Source: Ensembl
  24. negative regulation of growth of symbiont in host Source: Ensembl
  25. negative regulation of interleukin-6 production Source: Ensembl
  26. negative regulation of lipid catabolic process Source: Ensembl
  27. negative regulation of osteoblast differentiation Source: Ensembl
  28. negative regulation of protein complex disassembly Source: Ensembl
  29. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  30. negative regulation of viral genome replication Source: Ensembl
  31. organ morphogenesis Source: Ensembl
  32. osteoclast differentiation Source: Ensembl
  33. positive regulation of apoptotic process Source: Ensembl
  34. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  35. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
  36. positive regulation of chemokine biosynthetic process Source: Ensembl
  37. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  38. positive regulation of cytokine secretion Source: Ensembl
  39. positive regulation of fever generation Source: Ensembl
  40. positive regulation of hair follicle development Source: Ensembl
  41. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
  42. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  43. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  44. positive regulation of interferon-gamma production Source: Ensembl
  45. positive regulation of interleukin-6 production Source: Ensembl
  46. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
  47. positive regulation of JNK cascade Source: Ensembl
  48. positive regulation of JUN kinase activity Source: Ensembl
  49. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  50. positive regulation of NFAT protein import into nucleus Source: Ensembl
  51. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  52. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  53. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  54. positive regulation of osteoclast differentiation Source: Ensembl
  55. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  56. positive regulation of podosome assembly Source: Ensembl
  57. positive regulation of protein complex disassembly Source: Ensembl
  58. positive regulation of protein kinase B signaling Source: Ensembl
  59. positive regulation of protein localization to cell surface Source: Ensembl
  60. positive regulation of smooth muscle cell proliferation Source: Ensembl
  61. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  62. positive regulation of translational initiation by iron Source: Ensembl
  63. positive regulation of vitamin D biosynthetic process Source: Ensembl
  64. protein import into nucleus, translocation Source: Ensembl
  65. protein kinase B signaling Source: Ensembl
  66. receptor biosynthetic process Source: Ensembl
  67. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  68. regulation of immunoglobulin secretion Source: Ensembl
  69. regulation of insulin secretion Source: Ensembl
  70. regulation of reactive oxygen species metabolic process Source: Ensembl
  71. response to glucocorticoid Source: Ensembl
  72. response to virus Source: Ensembl
  73. sequestering of triglyceride Source: Ensembl
  74. transformed cell apoptotic process Source: Ensembl
  75. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of plasma membrane Source: Ensembl
  4. membrane raft Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA9LMQ0.
SMRiA9LMQ0. Positions 82-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9LMQ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEPLPKK AGGPPGSRRC FCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EELPNGLQLI SPLAQTVKSS SRTPSDKPVA HVVANPEAEG
110 120 130 140 150
QLQWLSRRAN ALLANGVELT DNQLIVPSDG LYLIYSQVLF KGQGCPSTHV
160 170 180 190 200
LLTHTISRFA VSYQTKVNLL SAIKSPCQRE TPEGTEAKPW YEPIYLGGVF
210 220 230
QLEKGDRLSA EINLPNYLDF AESGQVYFGI IAL
Length:233
Mass (Da):25,447
Last modified:February 5, 2008 - v1
Checksum:i7B2588FBC8B25340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU249361 mRNA. Translation: ABX26051.1.
RefSeqiNP_001003244.4. NM_001003244.4.
UniGeneiCfa.54.

Genome annotation databases

GeneIDi403922.
KEGGicfa:403922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU249361 mRNA. Translation: ABX26051.1 .
RefSeqi NP_001003244.4. NM_001003244.4.
UniGenei Cfa.54.

3D structure databases

ProteinModelPortali A9LMQ0.
SMRi A9LMQ0. Positions 82-233.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403922.
KEGGi cfa:403922.

Organism-specific databases

CTDi 7124.

Phylogenomic databases

HOVERGENi HBG012516.
KOi K03156.
OMAi PWYEPIY.

Miscellaneous databases

NextBioi 20817414.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Application of an intelligent cytokine responsive promoter for in vitro arthritis model."
    Rachakonda P.S., Rai M.F., Schmidt M.F.G.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Quantification of cytokines and inflammatory mediators in a three-dimensional model of inflammatory arthritis."
    Rai M.F., Sivaramakrishna Rachakonda P., Manning K., Vorwerk B., Brunnberg L., Kohn B., Schmidt M.F.
    Cytokine 42:8-17(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9LMQ0_CANFA
AccessioniPrimary (citable) accession number: A9LMQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)