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A9LMQ0

- A9LMQ0_CANFA

UniProt

A9LMQ0 - A9LMQ0_CANFA

Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. activation of MAPK activity Source: Ensembl
    3. activation of MAPKKK activity Source: Ensembl
    4. cellular amino acid biosynthetic process Source: Ensembl
    5. cellular response to amino acid stimulus Source: Ensembl
    6. cellular response to nicotine Source: Ensembl
    7. chronic inflammatory response to antigenic stimulus Source: Ensembl
    8. defense response to Gram-positive bacterium Source: Ensembl
    9. embryonic digestive tract development Source: Ensembl
    10. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    11. extracellular matrix organization Source: Ensembl
    12. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    13. glucose metabolic process Source: Ensembl
    14. humoral immune response Source: Ensembl
    15. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    16. JNK cascade Source: Ensembl
    17. leukocyte tethering or rolling Source: Ensembl
    18. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    19. necroptotic signaling pathway Source: Ensembl
    20. negative regulation of alkaline phosphatase activity Source: Ensembl
    21. negative regulation of branching involved in lung morphogenesis Source: Ensembl
    22. negative regulation of cytokine secretion involved in immune response Source: Ensembl
    23. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    24. negative regulation of glucose import Source: Ensembl
    25. negative regulation of growth of symbiont in host Source: Ensembl
    26. negative regulation of interleukin-6 production Source: Ensembl
    27. negative regulation of lipid catabolic process Source: Ensembl
    28. negative regulation of osteoblast differentiation Source: Ensembl
    29. negative regulation of protein complex disassembly Source: Ensembl
    30. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    31. negative regulation of viral genome replication Source: Ensembl
    32. organ morphogenesis Source: Ensembl
    33. osteoclast differentiation Source: Ensembl
    34. positive regulation of apoptotic process Source: Ensembl
    35. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    36. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
    37. positive regulation of chemokine biosynthetic process Source: Ensembl
    38. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
    39. positive regulation of cytokine secretion Source: Ensembl
    40. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    41. positive regulation of fever generation Source: Ensembl
    42. positive regulation of hair follicle development Source: Ensembl
    43. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
    44. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    45. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    46. positive regulation of interferon-gamma production Source: Ensembl
    47. positive regulation of interleukin-6 production Source: Ensembl
    48. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
    49. positive regulation of JNK cascade Source: Ensembl
    50. positive regulation of JUN kinase activity Source: Ensembl
    51. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    52. positive regulation of NFAT protein import into nucleus Source: Ensembl
    53. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    54. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    55. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    56. positive regulation of osteoclast differentiation Source: Ensembl
    57. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    58. positive regulation of podosome assembly Source: Ensembl
    59. positive regulation of protein complex disassembly Source: Ensembl
    60. positive regulation of protein kinase B signaling Source: Ensembl
    61. positive regulation of protein localization to cell surface Source: Ensembl
    62. positive regulation of smooth muscle cell proliferation Source: Ensembl
    63. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    64. positive regulation of translational initiation by iron Source: Ensembl
    65. positive regulation of vitamin D biosynthetic process Source: Ensembl
    66. protein import into nucleus, translocation Source: Ensembl
    67. protein kinase B signaling Source: Ensembl
    68. receptor biosynthetic process Source: Ensembl
    69. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
    70. regulation of immunoglobulin secretion Source: Ensembl
    71. regulation of insulin secretion Source: Ensembl
    72. response to glucocorticoid Source: Ensembl
    73. response to virus Source: Ensembl
    74. sequestering of triglyceride Source: Ensembl
    75. transformed cell apoptotic process Source: Ensembl
    76. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    CytokineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tumor necrosis factor alphaImported
    Gene namesi
    Name:TNFImported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. integral component of plasma membrane Source: Ensembl
    4. membrane raft Source: Ensembl
    5. phagocytic cup Source: Ensembl
    6. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane, SecretedSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA9LMQ0.
    SMRiA9LMQ0. Positions 82-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG012516.
    KOiK03156.
    OMAiPWYEPIY.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9LMQ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTESMIRDV ELAEEPLPKK AGGPPGSRRC FCLSLFSFLL VAGATTLFCL    50
    LHFGVIGPQR EELPNGLQLI SPLAQTVKSS SRTPSDKPVA HVVANPEAEG 100
    QLQWLSRRAN ALLANGVELT DNQLIVPSDG LYLIYSQVLF KGQGCPSTHV 150
    LLTHTISRFA VSYQTKVNLL SAIKSPCQRE TPEGTEAKPW YEPIYLGGVF 200
    QLEKGDRLSA EINLPNYLDF AESGQVYFGI IAL 233
    Length:233
    Mass (Da):25,447
    Last modified:February 5, 2008 - v1
    Checksum:i7B2588FBC8B25340
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU249361 mRNA. Translation: ABX26051.1.
    RefSeqiNP_001003244.4. NM_001003244.4.
    UniGeneiCfa.54.

    Genome annotation databases

    GeneIDi403922.
    KEGGicfa:403922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU249361 mRNA. Translation: ABX26051.1 .
    RefSeqi NP_001003244.4. NM_001003244.4.
    UniGenei Cfa.54.

    3D structure databases

    ProteinModelPortali A9LMQ0.
    SMRi A9LMQ0. Positions 82-233.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403922.
    KEGGi cfa:403922.

    Organism-specific databases

    CTDi 7124.

    Phylogenomic databases

    HOVERGENi HBG012516.
    KOi K03156.
    OMAi PWYEPIY.

    Miscellaneous databases

    NextBioi 20817414.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Application of an intelligent cytokine responsive promoter for in vitro arthritis model."
      Rachakonda P.S., Rai M.F., Schmidt M.F.G.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Quantification of cytokines and inflammatory mediators in a three-dimensional model of inflammatory arthritis."
      Rai M.F., Sivaramakrishna Rachakonda P., Manning K., Vorwerk B., Brunnberg L., Kohn B., Schmidt M.F.
      Cytokine 42:8-17(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA9LMQ0_CANFA
    AccessioniPrimary (citable) accession number: A9LMQ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)