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A9LMQ0

- A9LMQ0_CANFA

UniProt

A9LMQ0 - A9LMQ0_CANFA

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Protein
Submitted name: Tumor necrosis factor alpha
Gene
TNF
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. JNK cascade Source: Ensembl
  2. activation of MAPK activity Source: Ensembl
  3. activation of MAPKKK activity Source: Ensembl
  4. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  5. cellular amino acid biosynthetic process Source: Ensembl
  6. cellular response to amino acid stimulus Source: Ensembl
  7. cellular response to nicotine Source: Ensembl
  8. chronic inflammatory response to antigenic stimulus Source: Ensembl
  9. defense response to Gram-positive bacterium Source: Ensembl
  10. embryonic digestive tract development Source: Ensembl
  11. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  12. extracellular matrix organization Source: Ensembl
  13. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  14. glucose metabolic process Source: Ensembl
  15. humoral immune response Source: Ensembl
  16. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  17. leukocyte tethering or rolling Source: Ensembl
  18. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  19. necroptotic signaling pathway Source: Ensembl
  20. negative regulation of alkaline phosphatase activity Source: Ensembl
  21. negative regulation of branching involved in lung morphogenesis Source: Ensembl
  22. negative regulation of cytokine secretion involved in immune response Source: Ensembl
  23. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  24. negative regulation of glucose import Source: Ensembl
  25. negative regulation of growth of symbiont in host Source: Ensembl
  26. negative regulation of interleukin-6 production Source: Ensembl
  27. negative regulation of lipid catabolic process Source: Ensembl
  28. negative regulation of osteoblast differentiation Source: Ensembl
  29. negative regulation of protein complex disassembly Source: Ensembl
  30. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  31. negative regulation of viral genome replication Source: Ensembl
  32. organ morphogenesis Source: Ensembl
  33. osteoclast differentiation Source: Ensembl
  34. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  35. positive regulation of JNK cascade Source: Ensembl
  36. positive regulation of JUN kinase activity Source: Ensembl
  37. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  38. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  39. positive regulation of NFAT protein import into nucleus Source: Ensembl
  40. positive regulation of apoptotic process Source: Ensembl
  41. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  42. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
  43. positive regulation of chemokine biosynthetic process Source: Ensembl
  44. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  45. positive regulation of cytokine secretion Source: Ensembl
  46. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  47. positive regulation of fever generation Source: Ensembl
  48. positive regulation of hair follicle development Source: Ensembl
  49. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
  50. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  51. positive regulation of interferon-gamma production Source: Ensembl
  52. positive regulation of interleukin-6 production Source: Ensembl
  53. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
  54. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  55. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  56. positive regulation of osteoclast differentiation Source: Ensembl
  57. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  58. positive regulation of podosome assembly Source: Ensembl
  59. positive regulation of protein complex disassembly Source: Ensembl
  60. positive regulation of protein kinase B signaling Source: Ensembl
  61. positive regulation of protein localization to cell surface Source: Ensembl
  62. positive regulation of smooth muscle cell proliferation Source: Ensembl
  63. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  64. positive regulation of translational initiation by iron Source: Ensembl
  65. positive regulation of vitamin D biosynthetic process Source: Ensembl
  66. protein import into nucleus, translocation Source: Ensembl
  67. protein kinase B signaling Source: Ensembl
  68. receptor biosynthetic process Source: Ensembl
  69. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  70. regulation of immunoglobulin secretion Source: Ensembl
  71. regulation of insulin secretion Source: Ensembl
  72. response to glucocorticoid Source: Ensembl
  73. response to virus Source: Ensembl
  74. sequestering of triglyceride Source: Ensembl
  75. transformed cell apoptotic process Source: Ensembl
  76. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of plasma membrane Source: Ensembl
  4. membrane raft Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, SecretedSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliA9LMQ0.
SMRiA9LMQ0. Positions 82-233.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9LMQ0-1 [UniParc]FASTAAdd to Basket

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MSTESMIRDV ELAEEPLPKK AGGPPGSRRC FCLSLFSFLL VAGATTLFCL    50
LHFGVIGPQR EELPNGLQLI SPLAQTVKSS SRTPSDKPVA HVVANPEAEG 100
QLQWLSRRAN ALLANGVELT DNQLIVPSDG LYLIYSQVLF KGQGCPSTHV 150
LLTHTISRFA VSYQTKVNLL SAIKSPCQRE TPEGTEAKPW YEPIYLGGVF 200
QLEKGDRLSA EINLPNYLDF AESGQVYFGI IAL 233
Length:233
Mass (Da):25,447
Last modified:February 5, 2008 - v1
Checksum:i7B2588FBC8B25340
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU249361 mRNA. Translation: ABX26051.1.
RefSeqiNP_001003244.4. NM_001003244.4.
UniGeneiCfa.54.

Genome annotation databases

GeneIDi403922.
KEGGicfa:403922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU249361 mRNA. Translation: ABX26051.1 .
RefSeqi NP_001003244.4. NM_001003244.4.
UniGenei Cfa.54.

3D structure databases

ProteinModelPortali A9LMQ0.
SMRi A9LMQ0. Positions 82-233.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403922.
KEGGi cfa:403922.

Organism-specific databases

CTDi 7124.

Phylogenomic databases

HOVERGENi HBG012516.
KOi K03156.
OMAi PWYEPIY.

Miscellaneous databases

NextBioi 20817414.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Application of an intelligent cytokine responsive promoter for in vitro arthritis model."
    Rachakonda P.S., Rai M.F., Schmidt M.F.G.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Quantification of cytokines and inflammatory mediators in a three-dimensional model of inflammatory arthritis."
    Rai M.F., Sivaramakrishna Rachakonda P., Manning K., Vorwerk B., Brunnberg L., Kohn B., Schmidt M.F.
    Cytokine 42:8-17(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9LMQ0_CANFA
AccessioniPrimary (citable) accession number: A9LMQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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