A9LBE7 (A9LBE7_BURMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Bifunctional purine biosynthesis protein PurH HAMAP MF_00139

Gene names

Name:	purH HAMAP MF_00139 EMBL EDP84848.1
ORF Names:	BMA10399_J0224 EMBL EDP84848.1

Organism

Burkholderia mallei ATCC 10399 EMBL EDP84848.1

Taxonomic identifier

412021 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 SAAS SAAS002695 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 SAAS SAAS002695
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 SAAS SAAS002695 Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. HAMAP MF_00139 SAAS SAAS002695
Domain	The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP MF_00139
Sequence similarities	Belongs to the PurH family. HAMAP MF_00139

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS002695 HAMAP MF_00139
Molecular function	Hydrolase HAMAP MF_00139 SAAS SAAS002695 EMBL EDP84848.1 Transferase HAMAP MF_00139 SAAS SAAS002695 EMBL EDP84848.1
Technical term	Multifunctional enzyme HAMAP MF_00139 SAAS SAAS002695
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9LBE7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: CDDA7B76B25BB0E6	FASTA	521	55,458
	10 20 30 40 50 60 MIKQALISVS DKTGIVDFAK ALSALGVKLL STGGTAKLLA DAGLPVTEVA DYTGFPEMLD 70 80 90 100 110 120 GRVKTLHPKV HGGILARRDL PEHMQALEAH GIPTIDLLVV NLYPFVQTIA KDDCTLADAI 130 140 150 160 170 180 ENIDIGGPTM LRSAAKNHRD VTVVVDPADY AVVLDEMKAN GNTLGYKTNF RLATKVFAHT 190 200 210 220 230 240 AQYDGAITNY LTSLGDDLQH GSRSAYPATL NLAFDKVQDL RYGENPHQSA AFYRDVATPA 250 260 270 280 290 300 GALANYRQLQ GKELSYNNIA DSDAAWECVK TFDAPACVII KHANPCGVAV GADAGEAYAK 310 320 330 340 350 360 AFQTDPTSAF GGIIAFNREV DEAAAQAVAK QFVEVLIAPS FSDAAKQVFA AKQNVRLLEI 370 380 390 400 410 420 ALGEGHNAFD LKRVGGGLLV QSLDSKNVQP RELRVVTKRH PTPKEMDDLL FAWRVAKYVK 430 440 450 460 470 480 SNAIVFCGNG MTLGVGAGQM SRVDSARIAS IKAQNAGLTL AGSAVASDAF FPFRDGLDVV 490 500 510 520 VAAGATCVIQ PGGSVRDDEV IAAADEHNIA MVVTGVRHFR H

References

[1]	"Annotation of Burkholderia mallei ATCC 10399." DeShazer D., Woods D.E., Nierman W.C. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 10399 EMBL EDP84848.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS544749 Genomic DNA. Translation: EDP84848.1.
3D structure databases
ProteinModelPortal	A9LBE7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26909092. VBIBurMal41276_5549.
Phylogenomic databases
OMA	FTGTRHF.
Family and domain databases
HAMAP	MF_00139. PurH. [Tree]
InterPro	IPR024051. AICAR_Tfase_dom. IPR002695. AICARFT_IMPCHas. IPR016193. Cytidine_deaminase-like. IPR011607. MGS-like_dom. [Graphical view]
Gene3D	G3DSA:3.40.140.20. G3DSA:3.40.140.20. 2 hits. G3DSA:3.40.50.1380. MGS-like_dom. 1 hit.
PANTHER	PTHR11692. AICARFT_IMPCHas. 1 hit.
Pfam	PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view]
PIRSF	PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMART	SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit. SSF52335. MGS-like_dom. 1 hit.
TIGRFAMs	TIGR00355. PurH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9LBE7_BURMA

Accession

Primary (citable) accession number: A9LBE7

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)