A9L937 (HXA2_PAPAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A2

Gene names

Name:

HOXA2

Organism

Papio anubis (Olive baboon)

Taxonomic identifier

9555 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Homeobox protein Hox-A2		PRO_0000333802
Regions
	DNA binding	144 – 203	60	Homeobox
	Motif	94 – 99	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	A9L937 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5D289A5E10FEAEAB	FASTA	377	41,162
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PSNHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALP PAAAAAAAAA 130 140 150 160 170 180 AATGPACLSH KESLEIADGS GGGSRRLRTA YTNTQLLELE KEFHFNKYLC RPRRVEIAAL 190 200 210 220 230 240 LDLTERQVKV WFQNRRMKHK RQTQCKENQN SEGKCKSLED SEKVEEEEEE KTLFEQALSV 250 260 270 280 290 300 SGALLEREGY TFQQNALSQQ QAPSGHNGDS QSFPVSPLTS NEKNLKHFQH QSPTVPNCLS 310 320 330 340 350 360 TMGQNCGAGL NNDSPEALEV PSLQDFNVFS TDSCLQLSDT VSPSLPGSLD SPVDISADSF 370 DFFTDTLTTI DLQHLNY

References

[1]

"NISC comparative sequencing initiative." Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C., Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N. , Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K., Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000507 Genomic DNA. Translation: ABX52200.1.
RefSeq	NP_001162366.1. NM_001168895.1.
UniGene	Pan.18114.
3D structure databases
ProteinModelPortal	A9L937.
SMR	A9L937. Positions 144-202.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100137359.
Organism-specific databases
CTD	3199.
Phylogenomic databases
HOVERGEN	HBG006088.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2_PAPAN

Accession

Primary (citable) accession number: A9L937

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	March 6, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program