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A9L937

- HXA2_PAPAN

UniProt

A9L937 - HXA2_PAPAN

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Protein

Homeobox protein Hox-A2

Gene

HOXA2

Organism
Papio anubis (Olive baboon)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi144 – 20360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. brain segmentation Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. embryonic viscerocranium morphogenesis Source: Ensembl
  6. middle ear morphogenesis Source: Ensembl
  7. motor neuron axon guidance Source: Ensembl
  8. negative regulation of neuron differentiation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. rhombomere 2 development Source: Ensembl
  13. rhombomere 3 morphogenesis Source: Ensembl
  14. segment specification Source: Ensembl
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Gene namesi
Name:HOXA2
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Homeobox protein Hox-A2PRO_0000333802Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9L937.
SMRiA9L937. Positions 144-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006088.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9L937 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PSNHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE
110 120 130 140 150
KKAAKKTALP PAAAAAAAAA AATGPACLSH KESLEIADGS GGGSRRLRTA
160 170 180 190 200
YTNTQLLELE KEFHFNKYLC RPRRVEIAAL LDLTERQVKV WFQNRRMKHK
210 220 230 240 250
RQTQCKENQN SEGKCKSLED SEKVEEEEEE KTLFEQALSV SGALLEREGY
260 270 280 290 300
TFQQNALSQQ QAPSGHNGDS QSFPVSPLTS NEKNLKHFQH QSPTVPNCLS
310 320 330 340 350
TMGQNCGAGL NNDSPEALEV PSLQDFNVFS TDSCLQLSDT VSPSLPGSLD
360 370
SPVDISADSF DFFTDTLTTI DLQHLNY
Length:377
Mass (Da):41,162
Last modified:February 5, 2008 - v1
Checksum:i5D289A5E10FEAEAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000507 Genomic DNA. Translation: ABX52200.1.
RefSeqiNP_001162366.1. NM_001168895.1.
UniGeneiPan.18114.

Genome annotation databases

EnsembliENSPANT00000007826; ENSPANP00000010485; ENSPANG00000015067.
GeneIDi100137359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000507 Genomic DNA. Translation: ABX52200.1 .
RefSeqi NP_001162366.1. NM_001168895.1.
UniGenei Pan.18114.

3D structure databases

ProteinModelPortali A9L937.
SMRi A9L937. Positions 144-202.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPANT00000007826 ; ENSPANP00000010485 ; ENSPANG00000015067 .
GeneIDi 100137359.

Organism-specific databases

CTDi 3199.

Phylogenomic databases

GeneTreei ENSGT00760000118940.
HOVERGENi HBG006088.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHXA2_PAPAN
AccessioniPrimary (citable) accession number: A9L937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3