Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-A2

Gene

HOXA2

Organism
Papio anubis (Olive baboon)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi144 – 20360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. brain segmentation Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. cellular response to retinoic acid Source: Ensembl
  5. dorsal/ventral pattern formation Source: Ensembl
  6. embryonic viscerocranium morphogenesis Source: Ensembl
  7. middle ear morphogenesis Source: Ensembl
  8. motor neuron axon guidance Source: Ensembl
  9. negative regulation of neuron differentiation Source: Ensembl
  10. negative regulation of osteoblast differentiation Source: Ensembl
  11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. osteoblast development Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. rhombomere 2 development Source: Ensembl
  15. rhombomere 3 morphogenesis Source: Ensembl
  16. segment specification Source: Ensembl
  17. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Gene namesi
Name:HOXA2
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
ProteomesiUP000028761 Componenti: Chromosome 3

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Homeobox protein Hox-A2PRO_0000333802Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9L937.
SMRiA9L937. Positions 144-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006088.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9L937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PSNHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE
110 120 130 140 150
KKAAKKTALP PAAAAAAAAA AATGPACLSH KESLEIADGS GGGSRRLRTA
160 170 180 190 200
YTNTQLLELE KEFHFNKYLC RPRRVEIAAL LDLTERQVKV WFQNRRMKHK
210 220 230 240 250
RQTQCKENQN SEGKCKSLED SEKVEEEEEE KTLFEQALSV SGALLEREGY
260 270 280 290 300
TFQQNALSQQ QAPSGHNGDS QSFPVSPLTS NEKNLKHFQH QSPTVPNCLS
310 320 330 340 350
TMGQNCGAGL NNDSPEALEV PSLQDFNVFS TDSCLQLSDT VSPSLPGSLD
360 370
SPVDISADSF DFFTDTLTTI DLQHLNY
Length:377
Mass (Da):41,162
Last modified:February 5, 2008 - v1
Checksum:i5D289A5E10FEAEAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000507 Genomic DNA. Translation: ABX52200.1.
RefSeqiNP_001162366.1. NM_001168895.1.
UniGeneiPan.18114.

Genome annotation databases

EnsembliENSPANT00000007826; ENSPANP00000010485; ENSPANG00000015067.
GeneIDi100137359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000507 Genomic DNA. Translation: ABX52200.1.
RefSeqiNP_001162366.1. NM_001168895.1.
UniGeneiPan.18114.

3D structure databases

ProteinModelPortaliA9L937.
SMRiA9L937. Positions 144-202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPANT00000007826; ENSPANP00000010485; ENSPANG00000015067.
GeneIDi100137359.

Organism-specific databases

CTDi3199.

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006088.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHXA2_PAPAN
AccessioniPrimary (citable) accession number: A9L937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.