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A9L3Z6

- FTHS_SHEB9

UniProt

A9L3Z6 - FTHS_SHEB9

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Sbal195_3930
Organism
Shewanella baltica (strain OS195)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-4058-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Sbal195_3930
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000087655Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399599.Sbal195_3930.

Structurei

3D structure databases

ProteinModelPortaliA9L3Z6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9L3Z6-1 [UniParc]FASTAAdd to Basket

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MLTDMDISSR ASLKNITEIG VDLGLLPEEM MLFGHTKAKV ELSVLQRLAG    50
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP 100
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
EARLGKTEFE AQSGQAFLDI APNEIRWHRV VDHNDRCLRQ IHVGLGDNNG 200
PEYGSSFDIT AASELMAILA LSHDLADMRV RIGRLVLALN TQGQVITAED 250
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 300
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN 350
SGLATEVDSN VSNIHVPKIN AANINAPDQA RLEAGFANLN WHINNVARYG 400
IPVVVAINRF ATDSDAELQW LMEAVNASAA FGCEISDAFS QGEAGAIALA 450
QTVVRAAEIE SQFKLLYPDE ASLEAKLSTL AEVGYGAAGV SLSIEAKQQA 500
QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR ELVLHAGAGF 550
ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 585
Length:585
Mass (Da):61,417
Last modified:February 5, 2008 - v1
Checksum:i74B1B8472E03015F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX51090.1.
RefSeqiYP_001556350.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX51090; ABX51090; Sbal195_3930.
GeneIDi5755749.
KEGGisbn:Sbal195_3930.
PATRICi23474295. VBISheBal33754_4077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX51090.1 .
RefSeqi YP_001556350.1. NC_009997.1.

3D structure databases

ProteinModelPortali A9L3Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399599.Sbal195_3930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX51090 ; ABX51090 ; Sbal195_3930 .
GeneIDi 5755749.
KEGGi sbn:Sbal195_3930.
PATRICi 23474295. VBISheBal33754_4077.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SBAL399599:GH6B-4058-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195.

Entry informationi

Entry nameiFTHS_SHEB9
AccessioniPrimary (citable) accession number: A9L3Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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