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A9L3Z6

- FTHS_SHEB9

UniProt

A9L3Z6 - FTHS_SHEB9

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella baltica (strain OS195)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSBAL399599:GH6B-4058-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Sbal195_3930
    OrganismiShewanella baltica (strain OS195)
    Taxonomic identifieri399599 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000770: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Formate--tetrahydrofolate ligasePRO_1000087655Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399599.Sbal195_3930.

    Structurei

    3D structure databases

    ProteinModelPortaliA9L3Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9L3Z6-1 [UniParc]FASTAAdd to Basket

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    MLTDMDISSR ASLKNITEIG VDLGLLPEEM MLFGHTKAKV ELSVLQRLAG    50
    QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
    EARLGKTEFE AQSGQAFLDI APNEIRWHRV VDHNDRCLRQ IHVGLGDNNG 200
    PEYGSSFDIT AASELMAILA LSHDLADMRV RIGRLVLALN TQGQVITAED 250
    LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 300
    ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN 350
    SGLATEVDSN VSNIHVPKIN AANINAPDQA RLEAGFANLN WHINNVARYG 400
    IPVVVAINRF ATDSDAELQW LMEAVNASAA FGCEISDAFS QGEAGAIALA 450
    QTVVRAAEIE SQFKLLYPDE ASLEAKLSTL AEVGYGAAGV SLSIEAKQQA 500
    QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR ELVLHAGAGF 550
    ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 585
    Length:585
    Mass (Da):61,417
    Last modified:February 5, 2008 - v1
    Checksum:i74B1B8472E03015F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000891 Genomic DNA. Translation: ABX51090.1.
    RefSeqiYP_001556350.1. NC_009997.1.

    Genome annotation databases

    EnsemblBacteriaiABX51090; ABX51090; Sbal195_3930.
    GeneIDi5755749.
    KEGGisbn:Sbal195_3930.
    PATRICi23474295. VBISheBal33754_4077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000891 Genomic DNA. Translation: ABX51090.1 .
    RefSeqi YP_001556350.1. NC_009997.1.

    3D structure databases

    ProteinModelPortali A9L3Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399599.Sbal195_3930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX51090 ; ABX51090 ; Sbal195_3930 .
    GeneIDi 5755749.
    KEGGi sbn:Sbal195_3930.
    PATRICi 23474295. VBISheBal33754_4077.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SBAL399599:GH6B-4058-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS195.

    Entry informationi

    Entry nameiFTHS_SHEB9
    AccessioniPrimary (citable) accession number: A9L3Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3