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A9L3Z6 (FTHS_SHEB9) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Sbal195_3930
OrganismShewanella baltica (strain OS195) [Complete proteome] [HAMAP]
Taxonomic identifier399599 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087655

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9L3Z6 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 74B1B8472E03015F

FASTA58561,417
        10         20         30         40         50         60 
MLTDMDISSR ASLKNITEIG VDLGLLPEEM MLFGHTKAKV ELSVLQRLAG QRKGKLIIVT 

        70         80         90        100        110        120 
AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP VFGVKGGAAG GGYAQVVPMQ 

       130        140        150        160        170        180 
EMNLHLTGDI HAVSSAHNLG AAAIAARLFH EARLGKTEFE AQSGQAFLDI APNEIRWHRV 

       190        200        210        220        230        240 
VDHNDRCLRQ IHVGLGDNNG PEYGSSFDIT AASELMAILA LSHDLADMRV RIGRLVLALN 

       250        260        270        280        290        300 
TQGQVITAED LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 

       310        320        330        340        350        360 
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN SGLATEVDSN 

       370        380        390        400        410        420 
VSNIHVPKIN AANINAPDQA RLEAGFANLN WHINNVARYG IPVVVAINRF ATDSDAELQW 

       430        440        450        460        470        480 
LMEAVNASAA FGCEISDAFS QGEAGAIALA QTVVRAAEIE SQFKLLYPDE ASLEAKLSTL 

       490        500        510        520        530        540 
AEVGYGAAGV SLSIEAKQQA QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR 

       550        560        570        580 
ELVLHAGAGF ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS195."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS195.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000891 Genomic DNA. Translation: ABX51090.1.
RefSeqYP_001556350.1. NC_009997.1.

3D structure databases

ProteinModelPortalA9L3Z6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399599.Sbal195_3930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX51090; ABX51090; Sbal195_3930.
GeneID5755749.
KEGGsbn:Sbal195_3930.
PATRIC23474295. VBISheBal33754_4077.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycSBAL399599:GH6B-4058-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEB9
AccessionPrimary (citable) accession number: A9L3Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways