Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Shewanella baltica (strain OS195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101S-adenosyl-L-methionineUniRule annotation
Binding sitei45 – 451S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei66 – 661S-adenosyl-L-methionineUniRule annotation
Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-4038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:Sbal195_3910
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000770 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Thiopurine S-methyltransferasePRO_1000083762Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9L3X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276919.
KOiK00569.
OMAiPTWVETH.
OrthoDBiEOG6K3ZZV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9L3X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGFWHEKW HQQQIGFHQQ DINPFLVKYW QKLGLPADTQ VFVPLCGKSL
60 70 80 90 100
DMCFLAEQGH QVIGCELNEL AVQQFFSDIQ LEMTQTTVGE HQHYHTEQIS
110 120 130 140 150
LYQGDIFTLP KAITQEVTAF YDRAALIAWP ECMRAQYAKQ LASLLPSGSV
160 170 180 190 200
GLLVTLDYPQ EALSGPPFAV SPTWVEQHLS DDFDIGVLAS QDVLADNPRF
210
IKKAVPWLNE AAYLLKRK
Length:218
Mass (Da):24,776
Last modified:February 5, 2008 - v1
Checksum:i828C7A421EE50D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX51070.1.
RefSeqiWP_006084218.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX51070; ABX51070; Sbal195_3910.
GeneIDi11773918.
KEGGisbn:Sbal195_3910.
sbt:Sbal678_3940.
PATRICi23474253. VBISheBal33754_4056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX51070.1.
RefSeqiWP_006084218.1. NC_009997.1.

3D structure databases

ProteinModelPortaliA9L3X6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX51070; ABX51070; Sbal195_3910.
GeneIDi11773918.
KEGGisbn:Sbal195_3910.
sbt:Sbal678_3940.
PATRICi23474253. VBISheBal33754_4056.

Phylogenomic databases

HOGENOMiHOG000276919.
KOiK00569.
OMAiPTWVETH.
OrthoDBiEOG6K3ZZV.

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-4038-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195.

Entry informationi

Entry nameiTPMT_SHEB9
AccessioniPrimary (citable) accession number: A9L3X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 16, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.