A9L3U4 (ASTD_SHEB9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Sbal195_3878

Organism

Shewanella baltica (strain OS195) [Complete proteome] [HAMAP]

Taxonomic identifier

399599 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000085406
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9L3U4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 26ABA3769E4AD63E	FASTA	486	51,449
	10 20 30 40 50 60 MTHYIQGQWH AGKGHDVASI NPANAQTIWT GKTATAEQVN AAVDAAREAQ FDWFMLGFDA 70 80 90 100 110 120 RLAIVEAYRS QLEANKAELA ETIAQETGKP QWETATEVGA MIGKIALSAA AYNKRTGTEA 130 140 150 160 170 180 NDTPAGRAVI RHKPHGVVAV FGPYNFPGHL PNGHIVPALL AGNTVIFKPS ELTPKVAELM 190 200 210 220 230 240 VSLWDKAGLP AGVLNLVQGE VDTGKALASH PQLDGLFFTG SSRTGHFLHQ QYAGHPGKIL 250 260 270 280 290 300 ALEMGGNNPL IIKGVQDIKA AVHDILQSAY ISSGQRCTCA RRLYVEQGEQ GDALIAMLAA 310 320 330 340 350 360 AVKQIKVGPW NAQPQPFMGS MISETAAKGM VAAQTNLQNL GGVSLVELTH LEAGTGLVSP 370 380 390 400 410 420 GLIDVTAIDV LPDEEYFGPL LQLVRYSDFD QAIKLANQTR YGLSAGLLAD SREDYDYFLA 430 440 450 460 470 480 RIRAGIVNWN KQITGASGAA PFGGVGASGN HRASAFYAAD YCAYPVASVE ADAVSLPATL SPGLSL

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS195." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000891 Genomic DNA. Translation: ABX51038.1.
RefSeq	YP_001556298.1. NC_009997.1.
3D structure databases
ProteinModelPortal	A9L3U4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9L3U4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5755693.
GenomeReviews	Gene locus Sbal195_3878 in contig CP000891_GR.
KEGG	sbn:Sbal195_3878.
PATRIC	23474181. VBISheBal33754_4024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
OMA	EIENMDA.
ProtClustDB	PRK09457.
Enzyme and pathway databases
BioCyc	SBAL399599:SBAL195_3878-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SHEB9

Accession

Primary (citable) accession number: A9L3U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program