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A9L330

- GCSP_SHEB9

UniProt

A9L330 - GCSP_SHEB9

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella baltica (strain OS195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-3922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Sbal195_3799
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000083213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi399599.Sbal195_3799.

Structurei

3D structure databases

ProteinModelPortaliA9L330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L330-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKQTLTQLE QHDLFLRRHI GPDSNQQQAM LNFVGAESLE DLTAQIVPES
60 70 80 90 100
IRLSQDLSIG DSCGEAEGIA YIRGLADQNQ VFKSYIGMGY YGTQVPNVIL
110 120 130 140 150
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV
210 220 230 240 250
VGPASEAVNY ELFGALFQYT NRFGQITDFT ELFATLRAKN VIVTVAADIM
260 270 280 290 300
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR
310 320 330 340 350
IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV
360 370 380 390 400
FHGPDGLKTI ASRINRFADI LAAGLQAKGV SLVNSTWFDT ISIKGLDVAA
410 420 430 440 450
VNARALAAEM NLRFDTDGTV GISLDETTLR TDIDALFDVI LGAGHGLDVA
460 470 480 490 500
ALDAQIVSQG SQSIPAALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD
510 520 530 540 550
LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFSPL DQAKGYTQLI
560 570 580 590 600
EELSTWLVNI TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAENLSCI
660 670 680 690 700
MITYPSTHGV YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHVV VKPGRESDHN
760 770 780 790 800
GAVSAAPYGS AGILPISWMY IKLLGSQGLK KSTQTALLNA NYVMKKLSEH
810 820 830 840 850
YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPVDNNPLHN
910 920 930 940 950
APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN
960
LMCSCAPLSD YE
Length:962
Mass (Da):104,758
Last modified:February 5, 2008 - v1
Checksum:i7961A62EF7E096AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX50959.1.
RefSeqiYP_001556219.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX50959; ABX50959; Sbal195_3799.
GeneIDi5755613.
KEGGisbn:Sbal195_3799.
PATRICi23474014. VBISheBal33754_3941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX50959.1 .
RefSeqi YP_001556219.1. NC_009997.1.

3D structure databases

ProteinModelPortali A9L330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399599.Sbal195_3799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX50959 ; ABX50959 ; Sbal195_3799 .
GeneIDi 5755613.
KEGGi sbn:Sbal195_3799.
PATRICi 23474014. VBISheBal33754_3941.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SBAL399599:GH6B-3922-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195.

Entry informationi

Entry nameiGCSP_SHEB9
AccessioniPrimary (citable) accession number: A9L330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3