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A9L2G0 (A9L2G0_SHEB9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Sbal195_3763
OrganismShewanella baltica (strain OS195) [Complete proteome] [HAMAP] EMBL ABX50923.1
Taxonomic identifier399599 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6421Zinc By similarity HAMAP MF_00172
Metal binding6441Zinc By similarity HAMAP MF_00172
Metal binding7271Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
A9L2G0 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 4644B7E01B1C5C4D

FASTA75684,489
        10         20         30         40         50         60 
MQLNSLGFPR IGRRRELKFA LEKYWRGEIT QAELREVASE LRRTHWQWQT AAGIEQVPVG 

        70         80         90        100        110        120 
DFAFYDQVLT LSATLNAIPE RHRGEGAIDL DTLFRVARGR APTGQDAPAS EMTKYFNTNY 

       130        140        150        160        170        180 
HYLVPELTQN QEFSIAYEQF FDEVSEAQAL GYKAKPVLLG PVSYLHLAKT VGQEFDKLSL 

       190        200        210        220        230        240 
LPNLLTAYAD ILARFAVQGV EWVQLDEPVL ALELDTHWQA AMTKTYQALS TANVKVLLAS 

       250        260        270        280        290        300 
YYGGIAHHQA LVSALPVAGL HLDLVTAPKQ LAVFANALRS EQILSAGVVN GRNVWAADID 

       310        320        330        340        350        360 
LIAERIGAVA RDLGDRLWIG TSCSLLHSPV DLDVEVKLLP VLRKQLAFAK QKLLELSKIR 

       370        380        390        400        410        420 
QLLLAPNSDE AQKISAFCIA RRQAKAQAAD KQVIDRVAAL TAADYERVSD FSVRQSVQQQ 

       430        440        450        460        470        480 
KYRLPLLPTT TIGSFPQTPA IRGLRSRWRK GEISDAQYTE QLQQVTRDTI ERQLKLGIDV 

       490        500        510        520        530        540 
LVHGEAERND MVEYFGEQLA GVGFSKNGWV QSYGSRCVKP PLIYGDVSRP KAMTVDWAKF 

       550        560        570        580        590        600 
AQSLTDKPVK GMLTGPVTIL HWSFAREDIS RDAIATQLAL AIRDEVVDLQ NAGIGIIQID 

       610        620        630        640        650        660 
EPAFREGLPL KQSEWQTYLD WAVNAFKLSA AGVTDETQIH THMCYSEFND TIAAIAAMDA 

       670        680        690        700        710        720 
DVITIETSRS RMELLNAFED FEYPNEIGPG VYDIHSPNIP SVEAMVQLIE KAAQKVPVRQ 

       730        740        750 
LWVNPDCGLK TRTWDEVEPA LKNMVDATRE LRRRLG

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS195."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS195.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000891 Genomic DNA. Translation: ABX50923.1.
RefSeqYP_001556183.1. NC_009997.1.

3D structure databases

ProteinModelPortalA9L2G0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9L2G0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5755577.
GenomeReviewsGene locus Sbal195_3763 in contig CP000891_GR.
KEGGsbn:Sbal195_3763.
PATRIC23473940. VBISheBal33754_3904.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG287495.
OMANIWANDF.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycSBAL399599:SBAL195_3763-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9L2G0_SHEB9
AccessionPrimary (citable) accession number: A9L2G0
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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