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A9L1C6

- A9L1C6_SHEB9

UniProt

A9L1C6 - A9L1C6_SHEB9

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Protein

Quinolinate synthase A

Gene
nadA, Sbal195_2202
Organism
Shewanella baltica (strain OS195)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Iminoaspartate By similarityUniRule annotation
Binding sitei74 – 741Iminoaspartate; via amide nitrogen By similarityUniRule annotation
Binding sitei145 – 1451Iminoaspartate By similarityUniRule annotation
Binding sitei162 – 1621Iminoaspartate By similarityUniRule annotation
Binding sitei232 – 2321Iminoaspartate By similarityUniRule annotation
Binding sitei249 – 2491Iminoaspartate By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW
  4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-2264-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:Sbal195_2202Imported
OrganismiShewanella baltica (strain OS195)Imported
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi399599.Sbal195_2202.

Structurei

3D structure databases

ProteinModelPortaliA9L1C6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiKTVLMPT.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L1C6-1 [UniParc]FASTAAdd to Basket

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MSQFAPSPFA PTIETIDYPF PPKPVPLSDA QKADYKTRIK QLLIEKDAVL    50
VAHYYTDPEI QALAEETGGC VSDSLEMARF GRDHPAKTLI VAGVKFMGET 100
AKILSPEKTI LMPTLEATCS LDLGCPIDKF SAFCDAHPDH TVVVYANTSA 150
AVKARADWVV TSSIALEIVE HLDSESKKII WGPDRHLGSY IAKQTGAEML 200
MWQGDCIVHD EFKSNALRDM KSVYPDAAIL VHPESPANVV AMADAVGSTS 250
QLIKAAQTMP NERFIVATDR GIFYKMQQAA PGKILIEAPT GGNGATCKSC 300
AHCPWMAMNG LQAIEASLAD SDKTTHEIFV DEDLRVKALI PLTRMLDFAQ 350
TLNMKVKGNA 360
Length:360
Mass (Da):39,167
Last modified:February 5, 2008 - v1
Checksum:iC8C9FCD4263299BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1.
RefSeqiYP_001554631.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX49371; ABX49371; Sbal195_2202.
GeneIDi5753955.
KEGGisbn:Sbal195_2202.
PATRICi23470565. VBISheBal33754_2279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1 .
RefSeqi YP_001554631.1. NC_009997.1.

3D structure databases

ProteinModelPortali A9L1C6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399599.Sbal195_2202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX49371 ; ABX49371 ; Sbal195_2202 .
GeneIDi 5753955.
KEGGi sbn:Sbal195_2202.
PATRICi 23470565. VBISheBal33754_2279.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222769.
KOi K03517.
OMAi KTVLMPT.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci SBAL399599:GH6B-2264-MONOMER.

Family and domain databases

HAMAPi MF_00567. NadA_type1.
InterProi IPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195Imported.

Entry informationi

Entry nameiA9L1C6_SHEB9
AccessioniPrimary (citable) accession number: A9L1C6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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