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Protein

Quinolinate synthase A

Gene

nadA

Organism
Shewanella baltica (strain OS195)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterUniRule annotationSAAS annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotationSAAS annotation
  • [4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster per subunit.

Pathway: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531IminoaspartateUniRule annotation
Binding sitei74 – 741Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei145 – 1451IminoaspartateUniRule annotation
Binding sitei162 – 1621IminoaspartateUniRule annotation
Binding sitei232 – 2321IminoaspartateUniRule annotation
Binding sitei249 – 2491IminoaspartateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-2264-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotationSAAS annotation (EC:2.5.1.72UniRule annotationSAAS annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:Sbal195_2202Imported
OrganismiShewanella baltica (strain OS195)Imported
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA9L1C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiIAHPECE.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L1C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFAPSPFA PTIETIDYPF PPKPVPLSDA QKADYKTRIK QLLIEKDAVL
60 70 80 90 100
VAHYYTDPEI QALAEETGGC VSDSLEMARF GRDHPAKTLI VAGVKFMGET
110 120 130 140 150
AKILSPEKTI LMPTLEATCS LDLGCPIDKF SAFCDAHPDH TVVVYANTSA
160 170 180 190 200
AVKARADWVV TSSIALEIVE HLDSESKKII WGPDRHLGSY IAKQTGAEML
210 220 230 240 250
MWQGDCIVHD EFKSNALRDM KSVYPDAAIL VHPESPANVV AMADAVGSTS
260 270 280 290 300
QLIKAAQTMP NERFIVATDR GIFYKMQQAA PGKILIEAPT GGNGATCKSC
310 320 330 340 350
AHCPWMAMNG LQAIEASLAD SDKTTHEIFV DEDLRVKALI PLTRMLDFAQ
360
TLNMKVKGNA
Length:360
Mass (Da):39,167
Last modified:February 5, 2008 - v1
Checksum:iC8C9FCD4263299BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1.
RefSeqiWP_012197109.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX49371; ABX49371; Sbal195_2202.
KEGGisbn:Sbal195_2202.
PATRICi23470565. VBISheBal33754_2279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1.
RefSeqiWP_012197109.1. NC_009997.1.

3D structure databases

ProteinModelPortaliA9L1C6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX49371; ABX49371; Sbal195_2202.
KEGGisbn:Sbal195_2202.
PATRICi23470565. VBISheBal33754_2279.

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiIAHPECE.
OrthoDBiEOG6DJZ56.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.
BioCyciSBAL399599:GH6B-2264-MONOMER.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195Imported.

Entry informationi

Entry nameiA9L1C6_SHEB9
AccessioniPrimary (citable) accession number: A9L1C6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 24, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.