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A9L1C6

- A9L1C6_SHEB9

UniProt

A9L1C6 - A9L1C6_SHEB9

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Protein

Quinolinate synthase A

Gene

nadA

Organism
Shewanella baltica (strain OS195)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531IminoaspartateUniRule annotation
Binding sitei74 – 741Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei145 – 1451IminoaspartateUniRule annotation
Binding sitei162 – 1621IminoaspartateUniRule annotation
Binding sitei232 – 2321IminoaspartateUniRule annotation
Binding sitei249 – 2491IminoaspartateUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW
  4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-2264-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:Sbal195_2202Imported
OrganismiShewanella baltica (strain OS195)Imported
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi399599.Sbal195_2202.

Structurei

3D structure databases

ProteinModelPortaliA9L1C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiKTVLMPT.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L1C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQFAPSPFA PTIETIDYPF PPKPVPLSDA QKADYKTRIK QLLIEKDAVL
60 70 80 90 100
VAHYYTDPEI QALAEETGGC VSDSLEMARF GRDHPAKTLI VAGVKFMGET
110 120 130 140 150
AKILSPEKTI LMPTLEATCS LDLGCPIDKF SAFCDAHPDH TVVVYANTSA
160 170 180 190 200
AVKARADWVV TSSIALEIVE HLDSESKKII WGPDRHLGSY IAKQTGAEML
210 220 230 240 250
MWQGDCIVHD EFKSNALRDM KSVYPDAAIL VHPESPANVV AMADAVGSTS
260 270 280 290 300
QLIKAAQTMP NERFIVATDR GIFYKMQQAA PGKILIEAPT GGNGATCKSC
310 320 330 340 350
AHCPWMAMNG LQAIEASLAD SDKTTHEIFV DEDLRVKALI PLTRMLDFAQ
360
TLNMKVKGNA
Length:360
Mass (Da):39,167
Last modified:February 5, 2008 - v1
Checksum:iC8C9FCD4263299BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1.
RefSeqiWP_012197109.1. NC_009997.1.
YP_001554631.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX49371; ABX49371; Sbal195_2202.
GeneIDi5753955.
KEGGisbn:Sbal195_2202.
PATRICi23470565. VBISheBal33754_2279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49371.1 .
RefSeqi WP_012197109.1. NC_009997.1.
YP_001554631.1. NC_009997.1.

3D structure databases

ProteinModelPortali A9L1C6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399599.Sbal195_2202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX49371 ; ABX49371 ; Sbal195_2202 .
GeneIDi 5753955.
KEGGi sbn:Sbal195_2202.
PATRICi 23470565. VBISheBal33754_2279.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222769.
KOi K03517.
OMAi KTVLMPT.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci SBAL399599:GH6B-2264-MONOMER.

Family and domain databases

HAMAPi MF_00567. NadA_type1.
InterProi IPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195Imported.

Entry informationi

Entry nameiA9L1C6_SHEB9
AccessioniPrimary (citable) accession number: A9L1C6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3