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A9L1C6

- A9L1C6_SHEB9

UniProt

A9L1C6 - A9L1C6_SHEB9

Protein

Quinolinate synthase A

Gene

nadA

Organism
Shewanella baltica (strain OS195)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531IminoaspartateUniRule annotation
    Binding sitei74 – 741Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei145 – 1451IminoaspartateUniRule annotation
    Binding sitei162 – 1621IminoaspartateUniRule annotation
    Binding sitei232 – 2321IminoaspartateUniRule annotation
    Binding sitei249 – 2491IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methyltransferase activity Source: UniProtKB-KW
    4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciSBAL399599:GH6B-2264-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotation
    Ordered Locus Names:Sbal195_2202Imported
    OrganismiShewanella baltica (strain OS195)Imported
    Taxonomic identifieri399599 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000770: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi399599.Sbal195_2202.

    Structurei

    3D structure databases

    ProteinModelPortaliA9L1C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0379.
    HOGENOMiHOG000222769.
    KOiK03517.
    OMAiKTVLMPT.
    OrthoDBiEOG6DJZ56.

    Family and domain databases

    HAMAPiMF_00567. NadA_type1.
    InterProiIPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9L1C6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQFAPSPFA PTIETIDYPF PPKPVPLSDA QKADYKTRIK QLLIEKDAVL    50
    VAHYYTDPEI QALAEETGGC VSDSLEMARF GRDHPAKTLI VAGVKFMGET 100
    AKILSPEKTI LMPTLEATCS LDLGCPIDKF SAFCDAHPDH TVVVYANTSA 150
    AVKARADWVV TSSIALEIVE HLDSESKKII WGPDRHLGSY IAKQTGAEML 200
    MWQGDCIVHD EFKSNALRDM KSVYPDAAIL VHPESPANVV AMADAVGSTS 250
    QLIKAAQTMP NERFIVATDR GIFYKMQQAA PGKILIEAPT GGNGATCKSC 300
    AHCPWMAMNG LQAIEASLAD SDKTTHEIFV DEDLRVKALI PLTRMLDFAQ 350
    TLNMKVKGNA 360
    Length:360
    Mass (Da):39,167
    Last modified:February 5, 2008 - v1
    Checksum:iC8C9FCD4263299BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000891 Genomic DNA. Translation: ABX49371.1.
    RefSeqiYP_001554631.1. NC_009997.1.

    Genome annotation databases

    EnsemblBacteriaiABX49371; ABX49371; Sbal195_2202.
    GeneIDi5753955.
    KEGGisbn:Sbal195_2202.
    PATRICi23470565. VBISheBal33754_2279.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000891 Genomic DNA. Translation: ABX49371.1 .
    RefSeqi YP_001554631.1. NC_009997.1.

    3D structure databases

    ProteinModelPortali A9L1C6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399599.Sbal195_2202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX49371 ; ABX49371 ; Sbal195_2202 .
    GeneIDi 5753955.
    KEGGi sbn:Sbal195_2202.
    PATRICi 23470565. VBISheBal33754_2279.

    Phylogenomic databases

    eggNOGi COG0379.
    HOGENOMi HOG000222769.
    KOi K03517.
    OMAi KTVLMPT.
    OrthoDBi EOG6DJZ56.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci SBAL399599:GH6B-2264-MONOMER.

    Family and domain databases

    HAMAPi MF_00567. NadA_type1.
    InterProi IPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS195Imported.

    Entry informationi

    Entry nameiA9L1C6_SHEB9
    AccessioniPrimary (citable) accession number: A9L1C6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3