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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Shewanella baltica (strain OS195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631ZincUniRule annotation
Metal bindingi66 – 661ZincUniRule annotation
Metal bindingi160 – 1601ZincUniRule annotation
Active sitei224 – 2241UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-2260-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:Sbal195_2198
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Succinylglutamate desuccinylasePRO_1000083548Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399599.Sbal195_2198.

Structurei

3D structure databases

ProteinModelPortaliA9L1C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L1C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQALLDSKD FLALTLAHPE QFDSEFSFRL GDHTQVEVWD TGVIVFEPAQ
60 70 80 90 100
NEGKDVVLSC GVHGNETAPI ELCNGLIKQL LQQKIIAKQR TLFLIGNPLA
110 120 130 140 150
INNGTRIIDE NMNRLFSGEH SNPPGLVNPE RVRAKKLEAY IDRFYTAVAD
160 170 180 190 200
GRQRIHYDLH TAMRASKHEK FAIYPYRPGR AFSGEQIMFL AASGVDTVLF
210 220 230 240 250
HHEPTTTFSY FSSERYGADA FTIELGKVYP MGQNDMTRFI ATHEMFMRLI
260 270 280 290 300
TAKPLELDAF DADKVNLYQV CRVINKHFDD FEFTFATDVE NFRSFPKGFV
310 320 330 340
LAREGGQEIK VEHEFESVVF PNAKVPIGNR TVICLIPAVN ADVR
Length:344
Mass (Da):38,969
Last modified:February 5, 2008 - v1
Checksum:i10D217AF9EB4CD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49367.1.
RefSeqiWP_012197108.1. NC_009997.1.
YP_001554627.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX49367; ABX49367; Sbal195_2198.
GeneIDi11772341.
5753951.
KEGGisbn:Sbal195_2198.
PATRICi23470557. VBISheBal33754_2275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX49367.1.
RefSeqiWP_012197108.1. NC_009997.1.
YP_001554627.1. NC_009997.1.

3D structure databases

ProteinModelPortaliA9L1C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399599.Sbal195_2198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX49367; ABX49367; Sbal195_2198.
GeneIDi11772341.
5753951.
KEGGisbn:Sbal195_2198.
PATRICi23470557. VBISheBal33754_2275.

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.

Enzyme and pathway databases

UniPathwayiUPA00185; UER00283.
BioCyciSBAL399599:GH6B-2260-MONOMER.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195.

Entry informationi

Entry nameiASTE_SHEB9
AccessioniPrimary (citable) accession number: A9L1C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 29, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.