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A9L0U6

- LUXS_SHEB9

UniProt

A9L0U6 - LUXS_SHEB9

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Protein

S-ribosylhomocysteine lyase

Gene
luxS, Sbal195_3565
Organism
Shewanella baltica (strain OS195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Iron By similarity
Metal bindingi58 – 581Iron By similarity
Metal bindingi128 – 1281Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSBAL399599:GH6B-3688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:Sbal195_3565
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000770: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169S-ribosylhomocysteine lyaseUniRule annotationPRO_1000075458Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi399599.Sbal195_3565.

Structurei

3D structure databases

ProteinModelPortaliA9L0U6.
SMRiA9L0U6. Positions 3-163.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040371.
KOiK07173.
OMAiAWLASMN.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

A9L0U6-1 [UniParc]FASTAAdd to Basket

« Hide

MPLLDSFTVD HTRMNAPAVR VAKHMSTPKG DAITVFDLRF CAPNKDILSE    50
RGIHTLEHLF AGFMRDHLNG SNVEIIDISP MGCRTGFYMS LIGEPTERQV 100
ADAWLAAMED VLKVVEQSEI PELNEYQCGT YEMHSLEQAQ DIARNIIAAG 150
VSVNRNDDLK LSDEILGNL 169
Length:169
Mass (Da):18,831
Last modified:February 5, 2008 - v1
Checksum:i39D5153FFC734BEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX50727.1.
RefSeqiYP_001555987.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX50727; ABX50727; Sbal195_3565.
GeneIDi5755379.
KEGGisbn:Sbal195_3565.
PATRICi23473525. VBISheBal33754_3697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000891 Genomic DNA. Translation: ABX50727.1 .
RefSeqi YP_001555987.1. NC_009997.1.

3D structure databases

ProteinModelPortali A9L0U6.
SMRi A9L0U6. Positions 3-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399599.Sbal195_3565.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX50727 ; ABX50727 ; Sbal195_3565 .
GeneIDi 5755379.
KEGGi sbn:Sbal195_3565.
PATRICi 23473525. VBISheBal33754_3697.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040371.
KOi K07173.
OMAi AWLASMN.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci SBAL399599:GH6B-3688-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS195.

Entry informationi

Entry nameiLUXS_SHEB9
AccessioniPrimary (citable) accession number: A9L0U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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