A9KYG8 (A9KYG8_SHEB9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108

Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108

Gene names

Name:	ispD HAMAP MF_00108
Ordered Locus Names:	Sbal195_3277

Organism

Shewanella baltica (strain OS195) [Complete proteome] [HAMAP] EMBL ABX50439.1

Taxonomic identifier

399599 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108
Catalytic activity	CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108
Sequence similarities	Belongs to the IspD family. HAMAP MF_00108

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00108
Molecular function	Nucleotidyltransferase HAMAP MF_00108 EMBL ABX50439.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Site	52	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	59	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	188	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
	Site	244	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

	Sequence		Length	Mass (Da)
	A9KYG8 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: C9F688F85F7FC5AD	FASTA	263	28,082
	10 20 30 40 50 60 MSELGHLDLG LSEQSNPGSQ SEPVMQTELQ RQAEHITQAV VAIVPAAGIG SRMGADRPKQ 70 80 90 100 110 120 YLEVCGQSIL GHTLDKLLSH PHISNVIVAL HPNDTIFNTL PQAAHPKLTT VLGGGERADS 130 140 150 160 170 180 VLAALQIAPE HSWALVHDAA RPCLTATDID KLLASRVQFP QGAILAMPVR DTMKRANKQG 190 200 210 220 230 240 EICATVCRDN LWHALTPQLF QAAQLKDYLN AALAAGVVVT DEASAMEWAG ISPGLVSGRA 250 260 DNIKVTHPDD LGLAELFLMR AAK

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS195." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000891 Genomic DNA. Translation: ABX50439.1.
RefSeq	YP_001555699.1. NC_009997.1.
3D structure databases
ProteinModelPortal	A9KYG8.
ModBase	Search...
Protein-protein interaction databases
STRING	A9KYG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5755081.
GenomeReviews	Gene locus Sbal195_3277 in contig CP000891_GR.
KEGG	sbn:Sbal195_3277.
PATRIC	23472889. VBISheBal33754_3389.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG672839.
OMA	FPQGAIL.
ProtClustDB	PRK00155.
Enzyme and pathway databases
BioCyc	SBAL399599:SBAL195_3277-MONOMER.
Family and domain databases
HAMAP	MF_00108. IspD. [Tree]
InterPro	IPR001228. ISPD_synthase. [Graphical view]
KO	K00991.
Pfam	PF01128. IspD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00453. IspD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9KYG8_SHEB9

Accession

Primary (citable) accession number: A9KYG8

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)