A9KXF0 (CDD_SHEB9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase
Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	Sbal195_1716

Organism

Shewanella baltica (strain OS195) [Complete proteome] [HAMAP]

Taxonomic identifier

399599 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Cytidine deaminase HAMAP MF_01558		PRO_1000087797
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9KXF0 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 38576F5FF2B0442E	FASTA	296	31,951
	10 20 30 40 50 60 MQDRFIRSIT QLPTPLADAL IPMLHQNFAG HLDAQQLATL TSASKMTEAE VLLALLPIAA 70 80 90 100 110 120 ALAKPPISEF YVGAIAKGKS GDIYMGANLE LPGEALFHSV HAEQSAISHA WLSGESQIVD 130 140 150 160 170 180 IIVNASPCGH CRQFMNELVE GSKISIHLPA QESHPLAYYL PYAFGPKDLN VTSPLMAKQQ 190 200 210 220 230 240 TEFALDSADP MIIEGLDHAG LSYAPYTQSF AAVVLETRDG ATYCGRYAEN AAFNPSMLPM 250 260 270 280 290 QMALSNLVRH NREFSDISRA VLIESSQGKI SLVGATMDAL HTVAAIELEH IVIDPV

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS195." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000891 Genomic DNA. Translation: ABX48889.1.
RefSeq	YP_001554149.1. NC_009997.1.
3D structure databases
ProteinModelPortal	A9KXF0.
ModBase	Search...
Protein-protein interaction databases
STRING	A9KXF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5753452.
GenomeReviews	Gene locus Sbal195_1716 in contig CP000891_GR.
KEGG	sbn:Sbal195_1716.
PATRIC	23469528. VBISheBal33754_1778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG591160.
OMA	NRSHAPY.
ProtClustDB	PRK09027.
Enzyme and pathway databases
BioCyc	SBAL399599:SBAL195_1716-MONOMER.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR013171. Cyd/dCyd_deaminase_Zn-bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
KO	K01489.
PANTHER	PTHR11644:SF12. PTHR11644:SF12. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PIRSF	PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 2 hits.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SHEB9

Accession

Primary (citable) accession number: A9KXF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program