A9KXC4 (RIBA_SHEB9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase-2
EC=3.5.4.25

Alternative name(s):
GTP cyclohydrolase II

Gene names

Name:	ribA
Ordered Locus Names:	Sbal195_1690

Organism

Shewanella baltica (strain OS195) [Complete proteome] [HAMAP]

Taxonomic identifier

399599 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella baltica

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity. HAMAP-Rule MF_00179
Catalytic activity	GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate. HAMAP-Rule MF_00179
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00179
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4. HAMAP-Rule MF_00179
Sequence similarities	Belongs to the GTP cyclohydrolase II family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase II activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	GTP cyclohydrolase-2 HAMAP-Rule MF_00179		PRO_1000077260
Regions
	Nucleotide binding	49 – 53	5	GTP By similarity
	Nucleotide binding	92 – 94	3	GTP By similarity
Sites
	Active site	126	1	Proton acceptor Potential
	Active site	128	1	Nucleophile By similarity
	Metal binding	54	1	Zinc; catalytic By similarity
	Metal binding	65	1	Zinc; catalytic By similarity
	Metal binding	67	1	Zinc; catalytic By similarity
	Binding site	70	1	GTP By similarity
	Binding site	114	1	GTP By similarity
	Binding site	149	1	GTP By similarity
	Binding site	154	1	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9KXC4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 30E21281BB496A22	FASTA	204	23,015
	10 20 30 40 50 60 MSIKYVATSK LPTPWGVFAM HGFEDTESGK EHVALTFGTL SADEPVLGRI HSECLTGDAL 70 80 90 100 110 120 FSLRCDCGFQ LQAAMQNIAE TGSGFILYLR QEGRGIGLLN KIRAYELQDK GANTVEANEQ 130 140 150 160 170 180 LGFEADMRKY DMIKPMLEQI GVKHVRLMTN NPRKVKAMKE FGIEVVERVP LQVGKNRYNE 190 200 AYLKTKSTEL GHMMSEYHFM DENK

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS195." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Brettar I., Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000891 Genomic DNA. Translation: ABX48863.1.
RefSeq	YP_001554123.1. NC_009997.1.
3D structure databases
ProteinModelPortal	A9KXC4.
SMR	A9KXC4. Positions 1-173.
ModBase	Search...
Protein-protein interaction databases
STRING	399599.Sbal195_1690.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX48863; ABX48863; Sbal195_1690.
GeneID	5753426.
KEGG	sbn:Sbal195_1690.
PATRIC	23469472. VBISheBal33754_1750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0807.
HOGENOM	HOG000115442.
KO	K01497.
OMA	QGFILYL.
ProtClustDB	PRK00393.
Enzyme and pathway databases
BioCyc	SBAL399599:GH6B-1734-MONOMER.
UniPathway	UPA00275; UER00400.
Family and domain databases
HAMAP	MF_00179. RibA.
InterPro	IPR000926. GTP_CycHdrlaseII_RibA. [Graphical view]
Pfam	PF00925. GTP_cyclohydro2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00505. ribA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBA_SHEB9

Accession

Primary (citable) accession number: A9KXC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	May 29, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program