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Protein

NAD kinase

Gene

nadK

Organism
Shewanella baltica (strain OS195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei191NADUniRule annotation1
Binding sitei193NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 90NADUniRule annotation2
Nucleotide bindingi163 – 164NADUniRule annotation2
Nucleotide bindingi204 – 209NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Sbal195_1378
OrganismiShewanella baltica (strain OS195)
Taxonomic identifieri399599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000770 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795111 – 309NAD kinaseAdd BLAST309

Structurei

3D structure databases

ProteinModelPortaliA9KTL1.
SMRiA9KTL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227221.
KOiK00858.
OMAiVNLGHVG.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KTL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGINFDVSRP KARSSINMIT KFHTIGLIGK PHHQGTNQTL KRLHHWLTMQ
60 70 80 90 100
GFEVLVEERV AAELGPNIEA VDLLEIGARC DLAIVVGGDG NMLGAARVLA
110 120 130 140 150
RFDLGVIGVN RGNLGFLTDL PPDAFEEALA KVLDGEFDTE HRFLLEAEVY
160 170 180 190 200
RHGMLKASNT AVNEAVLHPG KIAHMIEFEV YIDDQFMYSQ RADGMIVSTP
210 220 230 240 250
TGSTAYALSA GGAILTPNLQ ALILVPMFPH TLSCRPIVVD ACSTIKMVVS
260 270 280 290 300
PDNGENLEVS CDGHVHLAVL PGDEIIVRRS SERLRLIHPK GHNYFHVLRT

KLGWGSKLF
Length:309
Mass (Da):33,871
Last modified:February 5, 2008 - v1
Checksum:iEC9445D16CFEBC91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000891 Genomic DNA. Translation: ABX48552.1.
RefSeqiWP_006085151.1. NC_009997.1.

Genome annotation databases

EnsemblBacteriaiABX48552; ABX48552; Sbal195_1378.
KEGGisbn:Sbal195_1378.

Similar proteinsi

Entry informationi

Entry nameiNADK_SHEB9
AccessioniPrimary (citable) accession number: A9KTL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: August 30, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families