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A9KSC7

- GSA2_CLOPH

UniProt

A9KSC7 - GSA2_CLOPH

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase 2
Gene
hemL2, Cphy_1789
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-1829-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2 (EC:5.4.3.8)
Short name:
GSA 2
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name:
GSA-AT 2
Gene namesi
Name:hemL2
Ordered Locus Names:Cphy_1789
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Glutamate-1-semialdehyde 2,1-aminomutase 2UniRule annotation
PRO_0000382299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357809.Cphy_1789.

Structurei

3D structure databases

ProteinModelPortaliA9KSC7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRFMVSGN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KSC7-1 [UniParc]FASTAAdd to Basket

« Hide

MTKSEQLFER AVKHLPGGVN SPVRAFLSVG GSPRFIESAD GAYIYDVDGN    50
KYIDYINSWG PMILGHNHEV IRTAVIEAAQ KGLSYGAATE AEVEMAELLC 100
EIVPCFEMVR MVNSGTEAVM SAIRAARGYT KRNKIIKFEG CYHGHSDGLL 150
VKAGSGVMVA GIPDSMGVPS NCVKDTLQAK YNNLDSVIEL FKQNKDEIAA 200
IIVEPVAANM GVVLPEEGFL EGLRELCTKH GALLIFDEVI TGFRLSLSGA 250
QGYYNIIPDL ATFGKIIGGG MPVGCYGGRR EIMEMVAPVG PVYQAGTLSG 300
NPVAMAAGMA QLKYLKEHPE VYTKINELGE YFRNKVNELF DKYNIKYQVS 350
GVGSLACIFF ADSRVTDYET AKLADTKEFA RYFRFMLEHG IYIAPAQFEA 400
MFFSNAHTYQ DIEDTLLVIE QYLKIQ 426
Length:426
Mass (Da):46,860
Last modified:February 5, 2008 - v1
Checksum:i4D10EB488D37D7A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42159.1.
RefSeqiWP_012199813.1. NC_010001.1.
YP_001558898.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX42159; ABX42159; Cphy_1789.
GeneIDi5743078.
KEGGicpy:Cphy_1789.
PATRICi19503222. VBICloPhy16213_1850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42159.1 .
RefSeqi WP_012199813.1. NC_010001.1.
YP_001558898.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KSC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_1789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX42159 ; ABX42159 ; Cphy_1789 .
GeneIDi 5743078.
KEGGi cpy:Cphy_1789.
PATRICi 19503222. VBICloPhy16213_1850.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RFMVSGN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CPHY357809:GHCL-1829-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiGSA2_CLOPH
AccessioniPrimary (citable) accession number: A9KSC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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