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A9KQK1

- A9KQK1_CLOPH

UniProt

A9KQK1 - A9KQK1_CLOPH

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Protein
Probable glycine dehydrogenase [decarboxylating] subunit 1
Gene
gcvPA, Cphy_1540
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-1582-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Cphy_1540Imported
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)Imported
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi357809.Cphy_1540.

Structurei

3D structure databases

ProteinModelPortaliA9KQK1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KQK1-1 [UniParc]FASTAAdd to Basket

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MGSFVPATDR DKKEMLSAIG IDSIEDLFGQ LPQDVKLMDG LNLPSGMSEM    50
EVCRKMEGIA AKNTVFPVIF RGAGAYRHYI PAVVKSVLSK ETLYTAYTPY 100
QAEISQGILQ SIFEYQTMIC ELTGMDTANA SVYDGAAAAA EAVAMCRDRK 150
KTKAFVSAAV HPQVMETIKT YCFGNGMELT VIPEKDGITD LNFLKEHIDG 200
QTACVYIQNP NYYGSLELAR EIGSIAKAAD AKYIMGVNPI SLGVIKTPEE 250
YGADIAVGEG QPLGLPLAFG GPYIGFMACT KELIRKLPGR IVGETVDFNG 300
KTGYVLTLQA REQHIRREKA LSNICSNQAL CALAVGVYLS AMGAEGLKQT 350
AIQCMSKAHY MANQLEAIGY PVINHGEFFH EFVTISKVPV EKVMSALEEA 400
GILGGYPLTG ERAGQILWCC TEMNAKDDID RVIGILREV 439
Length:439
Mass (Da):47,682
Last modified:February 5, 2008 - v1
Checksum:i18BC2C0E65A8A5EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX41914.1.
RefSeqiYP_001558653.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX41914; ABX41914; Cphy_1540.
GeneIDi5744362.
KEGGicpy:Cphy_1540.
PATRICi19502706. VBICloPhy16213_1592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX41914.1 .
RefSeqi YP_001558653.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KQK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_1540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX41914 ; ABX41914 ; Cphy_1540 .
GeneIDi 5744362.
KEGGi cpy:Cphy_1540.
PATRICi 19502706. VBICloPhy16213_1592.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CPHY357809:GHCL-1582-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiA9KQK1_CLOPH
AccessioniPrimary (citable) accession number: A9KQK1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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