Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciCPHY357809:G1GAJ-1600-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Cphy_1540Imported
OrganismiLachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)Imported
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000000370 Componenti: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi357809.Cphy_1540

Structurei

3D structure databases

ProteinModelPortaliA9KQK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A9KQK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFVPATDR DKKEMLSAIG IDSIEDLFGQ LPQDVKLMDG LNLPSGMSEM
60 70 80 90 100
EVCRKMEGIA AKNTVFPVIF RGAGAYRHYI PAVVKSVLSK ETLYTAYTPY
110 120 130 140 150
QAEISQGILQ SIFEYQTMIC ELTGMDTANA SVYDGAAAAA EAVAMCRDRK
160 170 180 190 200
KTKAFVSAAV HPQVMETIKT YCFGNGMELT VIPEKDGITD LNFLKEHIDG
210 220 230 240 250
QTACVYIQNP NYYGSLELAR EIGSIAKAAD AKYIMGVNPI SLGVIKTPEE
260 270 280 290 300
YGADIAVGEG QPLGLPLAFG GPYIGFMACT KELIRKLPGR IVGETVDFNG
310 320 330 340 350
KTGYVLTLQA REQHIRREKA LSNICSNQAL CALAVGVYLS AMGAEGLKQT
360 370 380 390 400
AIQCMSKAHY MANQLEAIGY PVINHGEFFH EFVTISKVPV EKVMSALEEA
410 420 430
GILGGYPLTG ERAGQILWCC TEMNAKDDID RVIGILREV
Length:439
Mass (Da):47,682
Last modified:February 5, 2008 - v1
Checksum:i18BC2C0E65A8A5EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA Translation: ABX41914.1
RefSeqiWP_012199568.1, NC_010001.1

Genome annotation databases

EnsemblBacteriaiABX41914; ABX41914; Cphy_1540
KEGGicpy:Cphy_1540

Similar proteinsi

Entry informationi

Entry nameiA9KQK1_LACP7
AccessioniPrimary (citable) accession number: A9KQK1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health