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A9KQK1

- A9KQK1_CLOPH

UniProt

A9KQK1 - A9KQK1_CLOPH

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-1582-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Cphy_1540Imported
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)Imported
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi357809.Cphy_1540.

Structurei

3D structure databases

ProteinModelPortaliA9KQK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KQK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSFVPATDR DKKEMLSAIG IDSIEDLFGQ LPQDVKLMDG LNLPSGMSEM
60 70 80 90 100
EVCRKMEGIA AKNTVFPVIF RGAGAYRHYI PAVVKSVLSK ETLYTAYTPY
110 120 130 140 150
QAEISQGILQ SIFEYQTMIC ELTGMDTANA SVYDGAAAAA EAVAMCRDRK
160 170 180 190 200
KTKAFVSAAV HPQVMETIKT YCFGNGMELT VIPEKDGITD LNFLKEHIDG
210 220 230 240 250
QTACVYIQNP NYYGSLELAR EIGSIAKAAD AKYIMGVNPI SLGVIKTPEE
260 270 280 290 300
YGADIAVGEG QPLGLPLAFG GPYIGFMACT KELIRKLPGR IVGETVDFNG
310 320 330 340 350
KTGYVLTLQA REQHIRREKA LSNICSNQAL CALAVGVYLS AMGAEGLKQT
360 370 380 390 400
AIQCMSKAHY MANQLEAIGY PVINHGEFFH EFVTISKVPV EKVMSALEEA
410 420 430
GILGGYPLTG ERAGQILWCC TEMNAKDDID RVIGILREV
Length:439
Mass (Da):47,682
Last modified:February 5, 2008 - v1
Checksum:i18BC2C0E65A8A5EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX41914.1.
RefSeqiYP_001558653.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX41914; ABX41914; Cphy_1540.
GeneIDi5744362.
KEGGicpy:Cphy_1540.
PATRICi19502706. VBICloPhy16213_1592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX41914.1 .
RefSeqi YP_001558653.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KQK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_1540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX41914 ; ABX41914 ; Cphy_1540 .
GeneIDi 5744362.
KEGGi cpy:Cphy_1540.
PATRICi 19502706. VBICloPhy16213_1592.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CPHY357809:GHCL-1582-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDgImported.

Entry informationi

Entry nameiA9KQK1_CLOPH
AccessioniPrimary (citable) accession number: A9KQK1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3