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A9KQK1 (A9KQK1_CLOPH) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712

EC=1.4.4.2 HAMAP-Rule MF_00712
Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712
Glycine dehydrogenase (aminomethyl-transferring) subunit 1 HAMAP-Rule MF_00712
Gene names
Name:gcvPA HAMAP-Rule MF_00712
Ordered Locus Names:Cphy_1540 EMBL ABX41914.1
OrganismClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) [Complete proteome] [HAMAP] EMBL ABX41914.1
Taxonomic identifier357809 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS020581

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS020581

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Sequences

Sequence LengthMass (Da)Tools
A9KQK1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 18BC2C0E65A8A5EC

FASTA43947,682
        10         20         30         40         50         60 
MGSFVPATDR DKKEMLSAIG IDSIEDLFGQ LPQDVKLMDG LNLPSGMSEM EVCRKMEGIA 

        70         80         90        100        110        120 
AKNTVFPVIF RGAGAYRHYI PAVVKSVLSK ETLYTAYTPY QAEISQGILQ SIFEYQTMIC 

       130        140        150        160        170        180 
ELTGMDTANA SVYDGAAAAA EAVAMCRDRK KTKAFVSAAV HPQVMETIKT YCFGNGMELT 

       190        200        210        220        230        240 
VIPEKDGITD LNFLKEHIDG QTACVYIQNP NYYGSLELAR EIGSIAKAAD AKYIMGVNPI 

       250        260        270        280        290        300 
SLGVIKTPEE YGADIAVGEG QPLGLPLAFG GPYIGFMACT KELIRKLPGR IVGETVDFNG 

       310        320        330        340        350        360 
KTGYVLTLQA REQHIRREKA LSNICSNQAL CALAVGVYLS AMGAEGLKQT AIQCMSKAHY 

       370        380        390        400        410        420 
MANQLEAIGY PVINHGEFFH EFVTISKVPV EKVMSALEEA GILGGYPLTG ERAGQILWCC 

       430 
TEMNAKDDID RVIGILREV 

« Hide

References

[1]"Complete genome sequence of Clostridium phytofermentans ISDg."
Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L., LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C. expand/collapse author list , Han C., Kuske C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.A., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700394 / DSM 18823 / ISDg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000885 Genomic DNA. Translation: ABX41914.1.
RefSeqYP_001558653.1. NC_010001.1.

3D structure databases

ProteinModelPortalA9KQK1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357809.Cphy_1540.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX41914; ABX41914; Cphy_1540.
GeneID5744362.
KEGGcpy:Cphy_1540.
PATRIC19502706. VBICloPhy16213_1592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycCPHY357809:GHCL-1582-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9KQK1_CLOPH
AccessionPrimary (citable) accession number: A9KQK1
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)