A9KQK1 (A9KQK1_CLOPH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712
EC=1.4.4.2 HAMAP-Rule MF_00712

Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712

Gene names

Name:	gcvPA HAMAP-Rule MF_00712
Ordered Locus Names:	Cphy_1540

Organism

Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) [Complete proteome] [HAMAP] EMBL ABX41914.1

Taxonomic identifier

357809 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium phytofermentans

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS023010
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_00712 SAAS SAAS023010 EMBL ABX41914.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine catabolic process Inferred from electronic annotation. Source: InterPro nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9KQK1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 18BC2C0E65A8A5EC	FASTA	439	47,682
	10 20 30 40 50 60 MGSFVPATDR DKKEMLSAIG IDSIEDLFGQ LPQDVKLMDG LNLPSGMSEM EVCRKMEGIA 70 80 90 100 110 120 AKNTVFPVIF RGAGAYRHYI PAVVKSVLSK ETLYTAYTPY QAEISQGILQ SIFEYQTMIC 130 140 150 160 170 180 ELTGMDTANA SVYDGAAAAA EAVAMCRDRK KTKAFVSAAV HPQVMETIKT YCFGNGMELT 190 200 210 220 230 240 VIPEKDGITD LNFLKEHIDG QTACVYIQNP NYYGSLELAR EIGSIAKAAD AKYIMGVNPI 250 260 270 280 290 300 SLGVIKTPEE YGADIAVGEG QPLGLPLAFG GPYIGFMACT KELIRKLPGR IVGETVDFNG 310 320 330 340 350 360 KTGYVLTLQA REQHIRREKA LSNICSNQAL CALAVGVYLS AMGAEGLKQT AIQCMSKAHY 370 380 390 400 410 420 MANQLEAIGY PVINHGEFFH EFVTISKVPV EKVMSALEEA GILGGYPLTG ERAGQILWCC 430 TEMNAKDDID RVIGILREV

References

[1]

"Complete genome sequence of Clostridium phytofermentans ISDg." Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L., LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C. , Han C., Kuske C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.A., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700394 / DSM 18823 / ISDg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000885 Genomic DNA. Translation: ABX41914.1.
RefSeq	YP_001558653.1. NC_010001.1.
3D structure databases
ProteinModelPortal	A9KQK1.
ModBase	Search...
Protein-protein interaction databases
STRING	357809.Cphy_1540.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX41914; ABX41914; Cphy_1540.
GeneID	5744362.
KEGG	cpy:Cphy_1540.
PATRIC	19502706. VBICloPhy16213_1592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HOG000132025.
KO	K00282.
OMA	MYDGASA.
ProtClustDB	CLSK978555.
Enzyme and pathway databases
BioCyc	CPHY357809:GHCL-1582-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9KQK1_CLOPH

Accession

Primary (citable) accession number: A9KQK1

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)