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A9KQC2

- GLPK_CLOPH

UniProt

A9KQC2 - GLPK_CLOPH

Protein

Glycerol kinase

Gene

glpK

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

    Enzyme regulationi

    Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121SubstrateUniRule annotation
    Binding sitei16 – 161ATPUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Binding sitei265 – 2651ATPUniRule annotation
    Binding sitei308 – 3081ATP; via carbonyl oxygenUniRule annotation
    Binding sitei312 – 3121ATP; via amide nitrogenUniRule annotation
    Binding sitei327 – 3271ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 143ATPUniRule annotation
    Nucleotide bindingi409 – 4135ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHY357809:GHCL-52-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:glpKUniRule annotation
    Ordered Locus Names:Cphy_0041
    OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
    Taxonomic identifieri357809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    ProteomesiUP000000370: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Glycerol kinasePRO_1000077414Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer and homodimer (in equilibrium).UniRule annotation

    Protein-protein interaction databases

    STRINGi357809.Cphy_0041.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KQC2.
    SMRiA9KQC2. Positions 2-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 832Substrate bindingUniRule annotation
    Regioni243 – 2442Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    KOiK00864.
    OMAiVVWNRKT.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KQC2-1 [UniParc]FASTAAdd to Basket

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    MEKYIMALDQ GTTSSRCILF NQRGEVCSVA QKEFTQVYPR TGWVEHRPMD    50
    IWSSQISVAA EAMAAIGAKA EDIDSIGITN QRETTIVWDK NTGEPVYNAI 100
    VWQCHRTADM IEQLKKDGFD SVIRKKTGLI PDAYFSATKI KWILDNVDGV 150
    RERAEAGSLL FGTVDTWIIW NLTKGRVHVT DYTNASRTML FDIHNLCWDD 200
    EILTYFKIPK SMLPKVQASS SIFGHTEEGL LGGEILISGA AGDQQAALFG 250
    QCCFEPGEVK NTYGTGCFLL MNTGDTAIES QNGLLTTIAA GDAGHIEYAL 300
    EGSVFVAGAA IQWLRDEQRM IKKASQSEEY AKEVEDTNGV YVVPAFTGLG 350
    APYWNPYARG TIVGITRGFS KEHMIRATLE SLAYQTVNVL HAMEQDSNIS 400
    LKSLRVDGGA SANNFLMQFQ ADVLNTLVYR PQCIETTALG AAYLAGLATG 450
    YFKDRNEIKD NWTLGGTFSP QMDEQKRKEL LKGWKRAVRC ALAWAEDIE 499
    Length:499
    Mass (Da):55,312
    Last modified:February 5, 2008 - v1
    Checksum:iAF7ABE5407A0B1E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX40431.1.
    RefSeqiYP_001557170.1. NC_010001.1.

    Genome annotation databases

    EnsemblBacteriaiABX40431; ABX40431; Cphy_0041.
    GeneIDi5744961.
    KEGGicpy:Cphy_0041.
    PATRICi19499534. VBICloPhy16213_0040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX40431.1 .
    RefSeqi YP_001557170.1. NC_010001.1.

    3D structure databases

    ProteinModelPortali A9KQC2.
    SMRi A9KQC2. Positions 2-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357809.Cphy_0041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX40431 ; ABX40431 ; Cphy_0041 .
    GeneIDi 5744961.
    KEGGi cpy:Cphy_0041.
    PATRICi 19499534. VBICloPhy16213_0040.

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    KOi K00864.
    OMAi VVWNRKT.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci CPHY357809:GHCL-52-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700394 / DSM 18823 / ISDg.

    Entry informationi

    Entry nameiGLPK_CLOPH
    AccessioniPrimary (citable) accession number: A9KQC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3