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A9KQC2

- GLPK_CLOPH

UniProt

A9KQC2 - GLPK_CLOPH

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Protein

Glycerol kinase

Gene
glpK, Cphy_0041
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121Substrate By similarity
Binding sitei16 – 161ATP By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei265 – 2651ATP By similarity
Binding sitei308 – 3081ATP; via carbonyl oxygen By similarity
Binding sitei312 – 3121ATP; via amide nitrogen By similarity
Binding sitei327 – 3271ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143ATP By similarity
Nucleotide bindingi409 – 4135ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-52-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name:
GK
Gene namesi
Name:glpK
Ordered Locus Names:Cphy_0041
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Glycerol kinaseUniRule annotationPRO_1000077414Add
BLAST

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium) By similarity.

Protein-protein interaction databases

STRINGi357809.Cphy_0041.

Structurei

3D structure databases

ProteinModelPortaliA9KQC2.
SMRiA9KQC2. Positions 2-496.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Substrate binding By similarity
Regioni243 – 2442Substrate binding By similarity

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiVVWNRKT.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KQC2-1 [UniParc]FASTAAdd to Basket

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MEKYIMALDQ GTTSSRCILF NQRGEVCSVA QKEFTQVYPR TGWVEHRPMD    50
IWSSQISVAA EAMAAIGAKA EDIDSIGITN QRETTIVWDK NTGEPVYNAI 100
VWQCHRTADM IEQLKKDGFD SVIRKKTGLI PDAYFSATKI KWILDNVDGV 150
RERAEAGSLL FGTVDTWIIW NLTKGRVHVT DYTNASRTML FDIHNLCWDD 200
EILTYFKIPK SMLPKVQASS SIFGHTEEGL LGGEILISGA AGDQQAALFG 250
QCCFEPGEVK NTYGTGCFLL MNTGDTAIES QNGLLTTIAA GDAGHIEYAL 300
EGSVFVAGAA IQWLRDEQRM IKKASQSEEY AKEVEDTNGV YVVPAFTGLG 350
APYWNPYARG TIVGITRGFS KEHMIRATLE SLAYQTVNVL HAMEQDSNIS 400
LKSLRVDGGA SANNFLMQFQ ADVLNTLVYR PQCIETTALG AAYLAGLATG 450
YFKDRNEIKD NWTLGGTFSP QMDEQKRKEL LKGWKRAVRC ALAWAEDIE 499
Length:499
Mass (Da):55,312
Last modified:February 5, 2008 - v1
Checksum:iAF7ABE5407A0B1E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX40431.1.
RefSeqiYP_001557170.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX40431; ABX40431; Cphy_0041.
GeneIDi5744961.
KEGGicpy:Cphy_0041.
PATRICi19499534. VBICloPhy16213_0040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX40431.1 .
RefSeqi YP_001557170.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KQC2.
SMRi A9KQC2. Positions 2-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_0041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX40431 ; ABX40431 ; Cphy_0041 .
GeneIDi 5744961.
KEGGi cpy:Cphy_0041.
PATRICi 19499534. VBICloPhy16213_0040.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi VVWNRKT.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci CPHY357809:GHCL-52-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiGLPK_CLOPH
AccessioniPrimary (citable) accession number: A9KQC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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