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A9KQ88

- A9KQ88_CLOPH

UniProt

A9KQ88 - A9KQ88_CLOPH

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Protein

Adenylosuccinate lyase

Gene

Cphy_3043

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-3097-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:Cphy_3043Imported
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)Imported
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_3043.

Structurei

3D structure databases

ProteinModelPortaliA9KQ88.
SMRiA9KQ88. Positions 1-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000033915.
KOiK01756.
OMAiMAHVHAY.
OrthoDBiEOG686NDB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KQ88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQDNYVSPL SERYASKEMQ YTFSPDMKFR TWRKLWIALA EAEHELGLPV
60 70 80 90 100
TSEQVEELKA HQDDINYEVA KERERLVRHD VMSHVYAYGV QCPNAKGIIH
110 120 130 140 150
LGATSCYVGD NTDIIVMTEG LKLVKKKLIC VMEELSKFAM KYRDLPTLAF
160 170 180 190 200
THFQPAQPTT VGKRATLWLQ ELALDLEDLE HALSCMKLLG SKGTTGTQAS
210 220 230 240 250
FLELFDGDHE KIKKLDALIA KKMGFEECFA VSGQTYSRKV DTRVLNVLAG
260 270 280 290 300
IAASAHKFSN DIRLLQHLKE IEEPFEKNQI GSSAMAYKRN PMRSERIASL
310 320 330 340 350
ARYVMVDALN PAITSATQWF ERTLDDSANK RLSVPEAFLA IDSILDLYMN
360 370 380 390 400
VVDGLVVYPK VIEKRLMSEL PFMATENIMM DAVKAGGDRQ ELHERIRTLS
410 420 430 440 450
MEAGRNVKEL GLENNLLELI AADPAFNMTL EDLKKVMEPS RYTGRAKEQT
460 470
EEFIESVIRP ILEENNELLG FKAEINV
Length:477
Mass (Da):54,068
Last modified:February 5, 2008 - v1
Checksum:i02F369FABF4C9627
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX43400.1.
RefSeqiWP_012201051.1. NC_010001.1.
YP_001560139.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX43400; ABX43400; Cphy_3043.
GeneIDi5743369.
KEGGicpy:Cphy_3043.
PATRICi19505910. VBICloPhy16213_3181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX43400.1 .
RefSeqi WP_012201051.1. NC_010001.1.
YP_001560139.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KQ88.
SMRi A9KQ88. Positions 1-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_3043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX43400 ; ABX43400 ; Cphy_3043 .
GeneIDi 5743369.
KEGGi cpy:Cphy_3043.
PATRICi 19505910. VBICloPhy16213_3181.

Phylogenomic databases

eggNOGi COG0015.
HOGENOMi HOG000033915.
KOi K01756.
OMAi MAHVHAY.
OrthoDBi EOG686NDB.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00132 .
UPA00075 ; UER00336 .
BioCyci CPHY357809:GHCL-3097-MONOMER.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
InterProi IPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SMARTi SM00998. ADSL_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00928. purB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDgImported.

Entry informationi

Entry nameiA9KQ88_CLOPH
AccessioniPrimary (citable) accession number: A9KQ88
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3