A9KNX6 (HIS1_CLOPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17

Gene names

Name:	hisG
Ordered Locus Names:	Cphy_2786

Organism

Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) [Complete proteome] [HAMAP]

Taxonomic identifier

357809 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium phytofermentans

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_01018
Catalytic activity	1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01018
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_01018
Subunit structure	Heteromultimer composed of HisG and HisZ subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Lacks the C-terminal regulatory region which is replaced by HisZ. HAMAP-Rule MF_01018
Sequence similarities	Belongs to the ATP phosphoribosyltransferase family. Short subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	ATP phosphoribosyltransferase HAMAP-Rule MF_01018		PRO_1000084156

Sequences

	Sequence		Length	Mass (Da)
	A9KNX6 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: DD8F972D5E54CF65	FASTA	215	24,091
	10 20 30 40 50 60 MKYITIALAK GRLAKKALEI LEQIGITCDE MKDPTSRKLI FTNEELKLRF FLAKANDVPT 70 80 90 100 110 120 YVEYGAADIG VVGKDTILEE GRKMYEVLDL NLGKCRMCIA GPASAKELLH HGELIRVATK 130 140 150 160 170 180 YPNIAKDYFY NKKHQTVEII KLNGSIELAP IVGLSEVIVD IVETGSTLKE NGLEVLEEIC 190 200 210 PLSARVVVNQ VSMKMEHERI TKMINDLREV LTEAQ

References

[1]

"Complete genome sequence of Clostridium phytofermentans ISDg." Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L., LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C. , Han C., Kuske C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.A., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700394 / DSM 18823 / ISDg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000885 Genomic DNA. Translation: ABX43146.1.
RefSeq	YP_001559885.1. NC_010001.1.
3D structure databases
ProteinModelPortal	A9KNX6.
ModBase	Search...
Protein-protein interaction databases
STRING	357809.Cphy_2786.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX43146; ABX43146; Cphy_2786.
GeneID	5742101.
KEGG	cpy:Cphy_2786.
PATRIC	19505334. VBICloPhy16213_2903.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0040.
HOGENOM	HOG000223248.
KO	K00765.
OMA	QVDIIKL.
ProtClustDB	PRK01686.
Enzyme and pathway databases
BioCyc	CPHY357809:GHCL-2867-MONOMER.
UniPathway	UPA00031; UER00006.
Family and domain databases
HAMAP	MF_01018. HisG_Short.
InterPro	IPR013820. ATP_PRibTrfase_cat. IPR018198. ATP_PRibTrfase_CS. IPR001348. ATP_PRibTrfase_HisG. IPR024893. ATP_PRibTrfase_HisG_short. [Graphical view]
PANTHER	PTHR21403. PTHR21403. 1 hit.
Pfam	PF01634. HisG. 1 hit. [Graphical view]
TIGRFAMs	TIGR00070. hisG. 1 hit.
PROSITE	PS01316. ATP_P_PHORIBOSYLTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS1_CLOPH

Accession

Primary (citable) accession number: A9KNX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program