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A9KNX6

- HIS1_CLOPH

UniProt

A9KNX6 - HIS1_CLOPH

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Protein
ATP phosphoribosyltransferase
Gene
hisG, Cphy_2786
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-2828-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:Cphy_2786
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215ATP phosphoribosyltransferaseUniRule annotation
PRO_1000084156Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits By similarity.

Protein-protein interaction databases

STRINGi357809.Cphy_2786.

Structurei

3D structure databases

ProteinModelPortaliA9KNX6.

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223248.
KOiK00765.
OMAiDVRLIIV.
OrthoDBiEOG66MQT3.

Family and domain databases

HAMAPiMF_01018. HisG_Short.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KNX6-1 [UniParc]FASTAAdd to Basket

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MKYITIALAK GRLAKKALEI LEQIGITCDE MKDPTSRKLI FTNEELKLRF    50
FLAKANDVPT YVEYGAADIG VVGKDTILEE GRKMYEVLDL NLGKCRMCIA 100
GPASAKELLH HGELIRVATK YPNIAKDYFY NKKHQTVEII KLNGSIELAP 150
IVGLSEVIVD IVETGSTLKE NGLEVLEEIC PLSARVVVNQ VSMKMEHERI 200
TKMINDLREV LTEAQ 215
Length:215
Mass (Da):24,091
Last modified:February 5, 2008 - v1
Checksum:iDD8F972D5E54CF65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX43146.1.
RefSeqiWP_012200797.1. NC_010001.1.
YP_001559885.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX43146; ABX43146; Cphy_2786.
GeneIDi5742101.
KEGGicpy:Cphy_2786.
PATRICi19505334. VBICloPhy16213_2903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX43146.1 .
RefSeqi WP_012200797.1. NC_010001.1.
YP_001559885.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KNX6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_2786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX43146 ; ABX43146 ; Cphy_2786 .
GeneIDi 5742101.
KEGGi cpy:Cphy_2786.
PATRICi 19505334. VBICloPhy16213_2903.

Phylogenomic databases

eggNOGi COG0040.
HOGENOMi HOG000223248.
KOi K00765.
OMAi DVRLIIV.
OrthoDBi EOG66MQT3.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci CPHY357809:GHCL-2828-MONOMER.

Family and domain databases

HAMAPi MF_01018. HisG_Short.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00070. hisG. 1 hit.
PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiHIS1_CLOPH
AccessioniPrimary (citable) accession number: A9KNX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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