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A9KNX6

- HIS1_CLOPH

UniProt

A9KNX6 - HIS1_CLOPH

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHY357809:GHCL-2828-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:Cphy_2786
    OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
    Taxonomic identifieri357809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    ProteomesiUP000000370: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215ATP phosphoribosyltransferasePRO_1000084156Add
    BLAST

    Interactioni

    Subunit structurei

    Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi357809.Cphy_2786.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KNX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Lacks the C-terminal regulatory region which is replaced by HisZ.

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0040.
    HOGENOMiHOG000223248.
    KOiK00765.
    OMAiDVRLIIV.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    HAMAPiMF_01018. HisG_Short.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR024893. ATP_PRibTrfase_HisG_short.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KNX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYITIALAK GRLAKKALEI LEQIGITCDE MKDPTSRKLI FTNEELKLRF    50
    FLAKANDVPT YVEYGAADIG VVGKDTILEE GRKMYEVLDL NLGKCRMCIA 100
    GPASAKELLH HGELIRVATK YPNIAKDYFY NKKHQTVEII KLNGSIELAP 150
    IVGLSEVIVD IVETGSTLKE NGLEVLEEIC PLSARVVVNQ VSMKMEHERI 200
    TKMINDLREV LTEAQ 215
    Length:215
    Mass (Da):24,091
    Last modified:February 5, 2008 - v1
    Checksum:iDD8F972D5E54CF65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX43146.1.
    RefSeqiWP_012200797.1. NC_010001.1.
    YP_001559885.1. NC_010001.1.

    Genome annotation databases

    EnsemblBacteriaiABX43146; ABX43146; Cphy_2786.
    GeneIDi5742101.
    KEGGicpy:Cphy_2786.
    PATRICi19505334. VBICloPhy16213_2903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX43146.1 .
    RefSeqi WP_012200797.1. NC_010001.1.
    YP_001559885.1. NC_010001.1.

    3D structure databases

    ProteinModelPortali A9KNX6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357809.Cphy_2786.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX43146 ; ABX43146 ; Cphy_2786 .
    GeneIDi 5742101.
    KEGGi cpy:Cphy_2786.
    PATRICi 19505334. VBICloPhy16213_2903.

    Phylogenomic databases

    eggNOGi COG0040.
    HOGENOMi HOG000223248.
    KOi K00765.
    OMAi DVRLIIV.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci CPHY357809:GHCL-2828-MONOMER.

    Family and domain databases

    HAMAPi MF_01018. HisG_Short.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR024893. ATP_PRibTrfase_HisG_short.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700394 / DSM 18823 / ISDg.

    Entry informationi

    Entry nameiHIS1_CLOPH
    AccessioniPrimary (citable) accession number: A9KNX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3