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A9KNK1 (UPPP_CLOPH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Cphy_2758
OrganismClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) [Complete proteome] [HAMAP]
Taxonomic identifier357809 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148808

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane219 – 23921Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9KNK1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 9E2B0BEDF140A8F5

FASTA27330,586
        10         20         30         40         50         60 
MDFIELLKVI FLGIVEGITE WLPISSTGHL LLVDEFLKVN LSKDFMSMFN VVIQLGAILA 

        70         80         90        100        110        120 
VVVLFFKKLW PFSKEEKNFI KKDTFTLWFK IVVACIPGIV MIPFDSKIED LFFNPQTIAT 

       130        140        150        160        170        180 
TLILYGILFI IIENRNAGKQ PKVAKLSDIT YQMAFMIGLF QILAMIPGTS RSGATIIGAM 

       190        200        210        220        230        240 
LFGASRYVAA EFTFFLAIPT MFGASLLKLL KFGFTFTGAE IVALITGMLT AFIVSIIVIK 

       250        260        270 
FLMGYIKKNN FKVFGWYRIV LGAIVAGYFL LAR 

« Hide

References

[1]"Complete genome sequence of Clostridium phytofermentans ISDg."
Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L., LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C. expand/collapse author list , Han C., Kuske C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.A., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700394 / DSM 18823 / ISDg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000885 Genomic DNA. Translation: ABX43118.1.
RefSeqYP_001559857.1. NC_010001.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357809.Cphy_2758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX43118; ABX43118; Cphy_2758.
GeneID5742073.
KEGGcpy:Cphy_2758.
PATRIC19505274. VBICloPhy16213_2873.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycCPHY357809:GHCL-2800-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CLOPH
AccessionPrimary (citable) accession number: A9KNK1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families