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A9KNJ5

- FTHS_CLOPH

UniProt

A9KNJ5 - FTHS_CLOPH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHY357809:GHCL-2794-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Cphy_2752
    OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
    Taxonomic identifieri357809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    ProteomesiUP000000370: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000333313Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357809.Cphy_2752.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KNJ5.
    SMRiA9KNJ5. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiDPKKINA.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KNJ5-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQE AKMIHIREVA KSLGITEDDL DFYGKYKAKF TDELWDEIKD    50
    REDGKLILVT AINPTPAGEG KTTTTVGLGQ AFGKLEKNAV IALREPSLGP 100
    CFGIKGGAAG GGYAQVVPME DLNLHFTGDF HAITSANNLL AAMLDNHIQQ 150
    GNTLGIDTNQ IVWKRCVDMN DRVLRNIVVG LGRKADGVVR EDHFIITVAS 200
    EIMAILCLAS DMNDLKERLS RIIVAYSYEG KPITAKDLHA VGSMAALLKD 250
    AIRPNLIQTL ENTPAIIHGG PFANIAHGCN SVRATKTALK LADYVITEAG 300
    FGADLGAEKF LDIKCRIADL KPAAVVLVAT IRALKYNGGV AKTDLSSENL 350
    EALEKGIVNL EKHIENIQKF GVPVVVTLNK FSTDTERELS YVKQFCEQRG 400
    CEFSLSEVWE KGGEGGIDLA NKVIKTIETK ESNYHVLYPN EMSLKEKMGT 450
    IAKEIYGADG VTFDSGALKE VERLTELGFG NLPVCMAKNQ YSLSDDPSKL 500
    GRPTNFTVNI REVYVSAGAG FVVAITGTVM TMPGLPKVPA AEHIDVNEEG 550
    VITGLF 556
    Length:556
    Mass (Da):60,275
    Last modified:February 5, 2008 - v1
    Checksum:i39973DD253DFBAE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX43112.1.
    RefSeqiWP_012200763.1. NC_010001.1.
    YP_001559851.1. NC_010001.1.

    Genome annotation databases

    EnsemblBacteriaiABX43112; ABX43112; Cphy_2752.
    GeneIDi5742067.
    KEGGicpy:Cphy_2752.
    PATRICi19505260. VBICloPhy16213_2866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX43112.1 .
    RefSeqi WP_012200763.1. NC_010001.1.
    YP_001559851.1. NC_010001.1.

    3D structure databases

    ProteinModelPortali A9KNJ5.
    SMRi A9KNJ5. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357809.Cphy_2752.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX43112 ; ABX43112 ; Cphy_2752 .
    GeneIDi 5742067.
    KEGGi cpy:Cphy_2752.
    PATRICi 19505260. VBICloPhy16213_2866.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi DPKKINA.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CPHY357809:GHCL-2794-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700394 / DSM 18823 / ISDg.

    Entry informationi

    Entry nameiFTHS_CLOPH
    AccessioniPrimary (citable) accession number: A9KNJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3