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A9KNJ5

- FTHS_CLOPH

UniProt

A9KNJ5 - FTHS_CLOPH

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-2794-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Cphy_2752
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000333313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_2752.

Structurei

3D structure databases

ProteinModelPortaliA9KNJ5.
SMRiA9KNJ5. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KNJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE AKMIHIREVA KSLGITEDDL DFYGKYKAKF TDELWDEIKD
60 70 80 90 100
REDGKLILVT AINPTPAGEG KTTTTVGLGQ AFGKLEKNAV IALREPSLGP
110 120 130 140 150
CFGIKGGAAG GGYAQVVPME DLNLHFTGDF HAITSANNLL AAMLDNHIQQ
160 170 180 190 200
GNTLGIDTNQ IVWKRCVDMN DRVLRNIVVG LGRKADGVVR EDHFIITVAS
210 220 230 240 250
EIMAILCLAS DMNDLKERLS RIIVAYSYEG KPITAKDLHA VGSMAALLKD
260 270 280 290 300
AIRPNLIQTL ENTPAIIHGG PFANIAHGCN SVRATKTALK LADYVITEAG
310 320 330 340 350
FGADLGAEKF LDIKCRIADL KPAAVVLVAT IRALKYNGGV AKTDLSSENL
360 370 380 390 400
EALEKGIVNL EKHIENIQKF GVPVVVTLNK FSTDTERELS YVKQFCEQRG
410 420 430 440 450
CEFSLSEVWE KGGEGGIDLA NKVIKTIETK ESNYHVLYPN EMSLKEKMGT
460 470 480 490 500
IAKEIYGADG VTFDSGALKE VERLTELGFG NLPVCMAKNQ YSLSDDPSKL
510 520 530 540 550
GRPTNFTVNI REVYVSAGAG FVVAITGTVM TMPGLPKVPA AEHIDVNEEG

VITGLF
Length:556
Mass (Da):60,275
Last modified:February 5, 2008 - v1
Checksum:i39973DD253DFBAE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX43112.1.
RefSeqiWP_012200763.1. NC_010001.1.
YP_001559851.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX43112; ABX43112; Cphy_2752.
GeneIDi5742067.
KEGGicpy:Cphy_2752.
PATRICi19505260. VBICloPhy16213_2866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX43112.1 .
RefSeqi WP_012200763.1. NC_010001.1.
YP_001559851.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KNJ5.
SMRi A9KNJ5. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_2752.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX43112 ; ABX43112 ; Cphy_2752 .
GeneIDi 5742067.
KEGGi cpy:Cphy_2752.
PATRICi 19505260. VBICloPhy16213_2866.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPHY357809:GHCL-2794-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiFTHS_CLOPH
AccessioniPrimary (citable) accession number: A9KNJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3