Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mannonate dehydratase

Gene

uxuA

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-1103-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:Cphy_1061
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000000370 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Mannonate dehydratasePRO_1000075898Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_1061.

Structurei

3D structure databases

ProteinModelPortaliA9KMJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiPOG091H06MP.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KMJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTFRWYGE GNDSITLKQI KQIPGCSGLM GVIDQYAAGE VWEESVIAEY
60 70 80 90 100
VEHVHKAGLE VEVIESVNVH EDIKLGLPSR ELYIENYIKT IRNLAKHGIK
110 120 130 140 150
VIVYNFMPVL DWLRTDLARV IEEDGSNSLY YDEEELLGLT PLQIVENTSK
160 170 180 190 200
SSNGFTLPGW EPERLKELEN VLALYKNIDP DKLRENYKYF LEKVIPVCEE
210 220 230 240 250
CGVKMAVHPD DPAWPIFGLP RIAHSEELFD KILELYDSES HTICLCTGSL
260 270 280 290 300
GSNPENNIPE IIRHFGGKNR VGCFHVRNVK YLGYRKFRES SHLSSDGSLD
310 320 330 340 350
MFEIMKAIHE TAPDTYIRPD HGRMIWDEVG RPGYGLYDRA LGIAYLNGIW

EALEKSSK
Length:358
Mass (Da):40,930
Last modified:February 5, 2008 - v1
Checksum:i12A4FBE0834F70F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX41441.1.
RefSeqiWP_012199087.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX41441; ABX41441; Cphy_1061.
KEGGicpy:Cphy_1061.
PATRICi19501726. VBICloPhy16213_1103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX41441.1.
RefSeqiWP_012199087.1. NC_010001.1.

3D structure databases

ProteinModelPortaliA9KMJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357809.Cphy_1061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX41441; ABX41441; Cphy_1061.
KEGGicpy:Cphy_1061.
PATRICi19501726. VBICloPhy16213_1103.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiPOG091H06MP.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciCPHY357809:GHCL-1103-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXUA_CLOPH
AccessioniPrimary (citable) accession number: A9KMJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.