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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandIron, Manganese

Enzyme and pathway databases

BioCyciCPHY357809:G1GAJ-1117-MONOMER
UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:Cphy_1061
OrganismiLachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000000370 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000758981 – 358Mannonate dehydrataseAdd BLAST358

Proteomic databases

PRIDEiA9KMJ6

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_1061

Structurei

3D structure databases

ProteinModelPortaliA9KMJ6
SMRiA9KMJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ Bacteria
COG1312 LUCA
HOGENOMiHOG000195381
KOiK01686
OMAiIPNGQVW
OrthoDBiPOG091H06MP

Family and domain databases

HAMAPiMF_00106 UxuA, 1 hit
InterProiView protein in InterPro
IPR004628 Man_deHydtase
IPR036237 Xyl_isomerase-like_sf
PANTHERiPTHR30387 PTHR30387, 1 hit
PfamiView protein in Pfam
PF03786 UxuA, 1 hit
PIRSFiPIRSF016049 Man_dehyd, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR00695 uxuA, 1 hit

Sequencei

Sequence statusi: Complete.

A9KMJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTFRWYGE GNDSITLKQI KQIPGCSGLM GVIDQYAAGE VWEESVIAEY
60 70 80 90 100
VEHVHKAGLE VEVIESVNVH EDIKLGLPSR ELYIENYIKT IRNLAKHGIK
110 120 130 140 150
VIVYNFMPVL DWLRTDLARV IEEDGSNSLY YDEEELLGLT PLQIVENTSK
160 170 180 190 200
SSNGFTLPGW EPERLKELEN VLALYKNIDP DKLRENYKYF LEKVIPVCEE
210 220 230 240 250
CGVKMAVHPD DPAWPIFGLP RIAHSEELFD KILELYDSES HTICLCTGSL
260 270 280 290 300
GSNPENNIPE IIRHFGGKNR VGCFHVRNVK YLGYRKFRES SHLSSDGSLD
310 320 330 340 350
MFEIMKAIHE TAPDTYIRPD HGRMIWDEVG RPGYGLYDRA LGIAYLNGIW

EALEKSSK
Length:358
Mass (Da):40,930
Last modified:February 5, 2008 - v1
Checksum:i12A4FBE0834F70F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA Translation: ABX41441.1
RefSeqiWP_012199087.1, NC_010001.1

Genome annotation databases

EnsemblBacteriaiABX41441; ABX41441; Cphy_1061
KEGGicpy:Cphy_1061

Similar proteinsi

Entry informationi

Entry nameiUXUA_LACP7
AccessioniPrimary (citable) accession number: A9KMJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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