Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9KMB6

- NADK_CLOPH

UniProt

A9KMB6 - NADK_CLOPH

Protein

NAD kinase

Gene

nadK

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Proton acceptorUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei168 – 1681NADUniRule annotation
    Binding sitei170 – 1701NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 652NADUniRule annotation
    Nucleotide bindingi140 – 1412NADUniRule annotation
    Nucleotide bindingi181 – 1866NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHY357809:GHCL-2549-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Cphy_2509
    OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
    Taxonomic identifieri357809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    ProteomesiUP000000370: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285NAD kinasePRO_1000079484Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357809.Cphy_2509.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KMB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9KMB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKFCIIANR DKDENLTITQ TMLEFLEANG KTVYVTEESC LEGSYTDVSG    50
    IPKDVECAIV LGGDGTILQA AHDLLQLDIP ILGVNLGTLG FLAEIETLTM 100
    KQAFSKLFLN QYNIESRMMI DATVFKEGQS LSSHKVSAIN DVVITRSGFS 150
    RIIGVSIFIN GEVVQNYRGD GVIISTPTGS TGYNLSAGGP IVTPKAEMIM 200
    ITPICPHSLN ARSIIVTSDD TVEIQIRESK KTQEEEAIVT VDGSFSMELQ 250
    ANDRILIKKA KERVKLVRLE GHSFFHLLRT KFGDK 285
    Length:285
    Mass (Da):31,308
    Last modified:February 5, 2008 - v1
    Checksum:i1FA779B2494232B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX42870.1.
    RefSeqiWP_012200523.1. NC_010001.1.
    YP_001559609.1. NC_010001.1.

    Genome annotation databases

    EnsemblBacteriaiABX42870; ABX42870; Cphy_2509.
    GeneIDi5742580.
    KEGGicpy:Cphy_2509.
    PATRICi19504746. VBICloPhy16213_2611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX42870.1 .
    RefSeqi WP_012200523.1. NC_010001.1.
    YP_001559609.1. NC_010001.1.

    3D structure databases

    ProteinModelPortali A9KMB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357809.Cphy_2509.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX42870 ; ABX42870 ; Cphy_2509 .
    GeneIDi 5742580.
    KEGGi cpy:Cphy_2509.
    PATRICi 19504746. VBICloPhy16213_2611.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CPHY357809:GHCL-2549-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700394 / DSM 18823 / ISDg.

    Entry informationi

    Entry nameiNADK_CLOPH
    AccessioniPrimary (citable) accession number: A9KMB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3