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A9KMB6

- NADK_CLOPH

UniProt

A9KMB6 - NADK_CLOPH

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Protein
NAD kinase
Gene
nadK, Cphy_2509
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptor By similarity
Binding sitei151 – 1511NAD By similarity
Binding sitei168 – 1681NAD By similarity
Binding sitei170 – 1701NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 652NAD By similarity
Nucleotide bindingi140 – 1412NAD By similarity
Nucleotide bindingi181 – 1866NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-2549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Cphy_2509
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285NAD kinaseUniRule annotation
PRO_1000079484Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_2509.

Structurei

3D structure databases

ProteinModelPortaliA9KMB6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KMB6-1 [UniParc]FASTAAdd to Basket

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MKKFCIIANR DKDENLTITQ TMLEFLEANG KTVYVTEESC LEGSYTDVSG    50
IPKDVECAIV LGGDGTILQA AHDLLQLDIP ILGVNLGTLG FLAEIETLTM 100
KQAFSKLFLN QYNIESRMMI DATVFKEGQS LSSHKVSAIN DVVITRSGFS 150
RIIGVSIFIN GEVVQNYRGD GVIISTPTGS TGYNLSAGGP IVTPKAEMIM 200
ITPICPHSLN ARSIIVTSDD TVEIQIRESK KTQEEEAIVT VDGSFSMELQ 250
ANDRILIKKA KERVKLVRLE GHSFFHLLRT KFGDK 285
Length:285
Mass (Da):31,308
Last modified:February 5, 2008 - v1
Checksum:i1FA779B2494232B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42870.1.
RefSeqiWP_012200523.1. NC_010001.1.
YP_001559609.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX42870; ABX42870; Cphy_2509.
GeneIDi5742580.
KEGGicpy:Cphy_2509.
PATRICi19504746. VBICloPhy16213_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42870.1 .
RefSeqi WP_012200523.1. NC_010001.1.
YP_001559609.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KMB6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_2509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX42870 ; ABX42870 ; Cphy_2509 .
GeneIDi 5742580.
KEGGi cpy:Cphy_2509.
PATRICi 19504746. VBICloPhy16213_2611.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CPHY357809:GHCL-2549-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiNADK_CLOPH
AccessioniPrimary (citable) accession number: A9KMB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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