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A9KLV5

- TRMB_CLOPH

UniProt

A9KLV5 - TRMB_CLOPH

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431S-adenosyl-L-methionineUniRule annotation
    Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
    Binding sitei95 – 951S-adenosyl-L-methionineUniRule annotation
    Active sitei117 – 1171By similarity
    Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCPHY357809:GHCL-3991-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Cphy_3917
    OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
    Taxonomic identifieri357809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    ProteomesiUP000000370: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214tRNA (guanine-N(7)-)-methyltransferasePRO_1000084440Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357809.Cphy_3917.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KLV5.
    SMRiA9KLV5. Positions 12-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 1944Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiDNVMTEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KLV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLRNIPGSR EYIAQNDYVV HDPEQKKGKW HEVFGNNNPI HIEIGMGKGQ    50
    FITSLAMQNP NINYIGIEKY SSVLLRAIEK REEYEGDNLY FLRFDAESIT 100
    DIFAPSEVDR IYLNFSDPWP KDRHSKRRLT SSEFLARYDQ FLVKDGYVAF 150
    KTDNRDLFDF SLEQVTLSGW QLRDVTFDLH HSEYVEGNIM TEYEERFSSM 200
    GNPIHRLVAF REKE 214
    Length:214
    Mass (Da):25,288
    Last modified:February 5, 2008 - v1
    Checksum:iC475FCC930292F97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX44264.1.
    RefSeqiWP_012201911.1. NC_010001.1.
    YP_001561003.1. NC_010001.1.

    Genome annotation databases

    EnsemblBacteriaiABX44264; ABX44264; Cphy_3917.
    GeneIDi5742048.
    KEGGicpy:Cphy_3917.
    PATRICi19507751. VBICloPhy16213_4084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000885 Genomic DNA. Translation: ABX44264.1 .
    RefSeqi WP_012201911.1. NC_010001.1.
    YP_001561003.1. NC_010001.1.

    3D structure databases

    ProteinModelPortali A9KLV5.
    SMRi A9KLV5. Positions 12-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357809.Cphy_3917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX44264 ; ABX44264 ; Cphy_3917 .
    GeneIDi 5742048.
    KEGGi cpy:Cphy_3917.
    PATRICi 19507751. VBICloPhy16213_4084.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi DNVMTEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CPHY357809:GHCL-3991-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700394 / DSM 18823 / ISDg.

    Entry informationi

    Entry nameiTRMB_CLOPH
    AccessioniPrimary (citable) accession number: A9KLV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3