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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-2320-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Cphy_2280
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Lachnoclostridium phytofermentans)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000000370 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_1000075998Add
BLAST

Proteomic databases

PRIDEiA9KK69.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi357809.Cphy_2280.

Structurei

3D structure databases

ProteinModelPortaliA9KK69.
SMRiA9KK69. Positions 4-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004402.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiEOG6X6RBB.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KK69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQDFYFDL PEELIAQDPL EDRSGSRLLV LDKNTGKVTH HIFKEIVKYL
60 70 80 90 100
KKGDCLVLNN TKVIPARLMG ERIIEKTPLA PGHSYGKEGT PIELLLLKRK
110 120 130 140 150
PDDVWETLVR PGKKAKVGTK ISFGDGKLIG EIIDVVEEGN RLVKFTYQGI
160 170 180 190 200
FEEILDELGQ MPLPPYITHE LADKNRYQTV YAKHEGSAAA PTAGLHFTNE
210 220 230 240 250
LLKQIEDMGV VIANVTLHVG LGTFRPVKED DILDHHMHSE VYQVEESEAK
260 270 280 290 300
KINDAKRAGG RIICVGTTSC RTIESAANED GFVQAKSGAT EIFIYPGYKF
310 320 330 340 350
KVLNCLITNF HLPESTLLML VSALASREHI IAAYEEAVKE RYRFFSFGDA
360
MFITDNIIET KDTF
Length:364
Mass (Da):40,898
Last modified:February 5, 2008 - v1
Checksum:i7EABD47CFF5D195A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX42641.1.
RefSeqiWP_012200295.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX42641; ABX42641; Cphy_2280.
KEGGicpy:Cphy_2280.
PATRICi19504284. VBICloPhy16213_2380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA. Translation: ABX42641.1.
RefSeqiWP_012200295.1. NC_010001.1.

3D structure databases

ProteinModelPortaliA9KK69.
SMRiA9KK69. Positions 4-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357809.Cphy_2280.

Proteomic databases

PRIDEiA9KK69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX42641; ABX42641; Cphy_2280.
KEGGicpy:Cphy_2280.
PATRICi19504284. VBICloPhy16213_2380.

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004402.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiEOG6X6RBB.

Enzyme and pathway databases

UniPathwayiUPA00392.
BioCyciCPHY357809:GHCL-2320-MONOMER.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiQUEA_CLOPH
AccessioniPrimary (citable) accession number: A9KK69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.