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A9KHL4

- ASSY_CLOPH

UniProt

A9KHL4 - ASSY_CLOPH

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Protein
Argininosuccinate synthase
Gene
argG, Cphy_1931
Organism
Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei187 – 1871Citrulline By similarity
Binding sitei264 – 2641Citrulline By similarity
Binding sitei276 – 2761Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:GHCL-1971-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Cphy_1931
OrganismiClostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000000370: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthaseUniRule annotation
PRO_0000329468Add
BLAST

Proteomic databases

PRIDEiA9KHL4.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357809.Cphy_1931.

Structurei

3D structure databases

ProteinModelPortaliA9KHL4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KHL4-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKVILAYS GGLDTTAIIP WLKENYDYDV VCCCIDVGQG NELDGLEERA    50
KLSGATKLYI EHVTDEFVDE YVMPCVKAGA VYENKYLLGT SMARPVIAKK 100
LVEVAIKENA VAICHGATGK GNDQVRFELG IKALAPDLKI IAPWRCNNTW 150
KMQSREDEIE YCKAHGIDLP FDASHSYSRD RNLWHISHEG LELEDPANAP 200
NYDHLLVLGV SPEKAPNEAE SLSLTFEKGI PVALNGKAMK ASEIIEELNV 250
LGGKYGIGII DIVENRVVGM KSRGVYETPG GTILMEAHTQ LEELILDRAT 300
LSCKKEIGNK FADVVYEGKW FTPLREALQA FVEVTQEYVT GEVKLKLYKG 350
NIIKQGTTSP YSLYNESIAS FTTGELYNHH DAEGFINLFG LSLKVRAMKM 400
AEVEKNK 407
Length:407
Mass (Da):45,218
Last modified:February 5, 2008 - v1
Checksum:i5DD540F4E211BAE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42299.1.
RefSeqiWP_012199953.1. NC_010001.1.
YP_001559038.1. NC_010001.1.

Genome annotation databases

EnsemblBacteriaiABX42299; ABX42299; Cphy_1931.
GeneIDi5744610.
KEGGicpy:Cphy_1931.
PATRICi19503534. VBICloPhy16213_2006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000885 Genomic DNA. Translation: ABX42299.1 .
RefSeqi WP_012199953.1. NC_010001.1.
YP_001559038.1. NC_010001.1.

3D structure databases

ProteinModelPortali A9KHL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357809.Cphy_1931.

Proteomic databases

PRIDEi A9KHL4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX42299 ; ABX42299 ; Cphy_1931 .
GeneIDi 5744610.
KEGGi cpy:Cphy_1931.
PATRICi 19503534. VBICloPhy16213_2006.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CPHY357809:GHCL-1971-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700394 / DSM 18823 / ISDg.

Entry informationi

Entry nameiASSY_CLOPH
AccessioniPrimary (citable) accession number: A9KHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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