A9KFP2 (UVRC_COXBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	CBUD_1276

Organism

Coxiella burnetii (strain Dugway 5J108-111) [Complete proteome] [HAMAP]

Taxonomic identifier

434922 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	UvrABC system protein C HAMAP-Rule MF_00203		PRO_1000077777
Regions
	Domain	15 – 92	78	GIY-YIG
	Domain	202 – 237	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	A9KFP2 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 3617D3FFD3087FD5	FASTA	609	69,061
	10 20 30 40 50 60 MTIDNPSAFL KTLPTGSGVY QIQDAQGKVI YVGKARNLQK RVSSYFRRQL DSKTQAMMAQ 70 80 90 100 110 120 VQSIQTTITR NENEALLLEA SFIKQFRPRY NVLLRDDKSY PYLYLATHQK FPRLDFYRGA 130 140 150 160 170 180 KKAPGRYFGP YPNAGSVREN LALIQKLFKL RQCSESFFKN RTRPCLQYQI KRCTAPCVGY 190 200 210 220 230 240 VNEQEYRRQV EDAILFFEGK NDQVIIKLTE RMEVASENLV FEEAAHYRDQ IRQLRRLQKQ 250 260 270 280 290 300 QIITGGKGNI DIIGIAESNG AIGFAILFIR SGRMIGHKPF FPNTPLGTTL QTALVEFIPQ 310 320 330 340 350 360 YYLSPLRNGD IPERIVTSEP LEDRLWIQRA LSSGLNRRLA ITDQKRAPYK QWQAMAALNA 370 380 390 400 410 420 AQALSQHLAQ KNTFALKLEA IQKSLALPNP IARIECFDIS HTLGEATVAS CVVFGEEGLI 430 440 450 460 470 480 KKDYRRFNIS GVTPGDDYGA LRQALTRRYV RLKEGEGILP DVLLIDGGMG QLRQAAEVLE 490 500 510 520 530 540 ELQVSGVILT AIAKGPGRKA GLEKLFVWGR REEIHLPADN IAFHLIQQIR DEAHRFAITA 550 560 570 580 590 600 HCNRRAKRRV ESTLQEIEGI GPKRRQKLLK YFGGLQELQR ASIEEIARVP GVSETLAKAI YDACHQHKG

References

[1]

"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella." Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A. Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Dugway 5J108-111.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000733 Genomic DNA. Translation: ABS77103.1.
RefSeq	YP_001424631.1. NC_009727.1.
3D structure databases
ProteinModelPortal	A9KFP2.
SMR	A9KFP2. Positions 552-601.
ModBase	Search...
Protein-protein interaction databases
STRING	434922.CBUD_1276.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS77103; ABS77103; CBUD_1276.
GeneID	5457475.
KEGG	cbd:CBUD_1276.
PATRIC	17922385. VBICoxBur32972_1287.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279961.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	PRK00558.
Enzyme and pathway databases
BioCyc	CBUR434922:GJTP-1354-MONOMER.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_COXBN

Accession

Primary (citable) accession number: A9KFP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program