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A9KFP2

- UVRC_COXBN

UniProt

A9KFP2 - UVRC_COXBN

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Protein
UvrABC system protein C
Gene
uvrC, CBUD_1276
Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciCBUR434922:GJTP-1354-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:CBUD_1276
OrganismiCoxiella burnetii (strain Dugway 5J108-111)
Taxonomic identifieri434922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008555: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609UvrABC system protein CUniRule annotation
PRO_1000077777Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex By similarity.

Protein-protein interaction databases

STRINGi434922.CBUD_1276.

Structurei

3D structure databases

ProteinModelPortaliA9KFP2.
SMRiA9KFP2. Positions 552-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278GIY-YIG
Add
BLAST
Domaini202 – 23736UVR
Add
BLAST

Sequence similaritiesi

Belongs to the UvrC family.
Contains 1 GIY-YIG domain.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279961.
KOiK03703.
OMAiQTIASCV.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KFP2-1 [UniParc]FASTAAdd to Basket

« Hide

MTIDNPSAFL KTLPTGSGVY QIQDAQGKVI YVGKARNLQK RVSSYFRRQL    50
DSKTQAMMAQ VQSIQTTITR NENEALLLEA SFIKQFRPRY NVLLRDDKSY 100
PYLYLATHQK FPRLDFYRGA KKAPGRYFGP YPNAGSVREN LALIQKLFKL 150
RQCSESFFKN RTRPCLQYQI KRCTAPCVGY VNEQEYRRQV EDAILFFEGK 200
NDQVIIKLTE RMEVASENLV FEEAAHYRDQ IRQLRRLQKQ QIITGGKGNI 250
DIIGIAESNG AIGFAILFIR SGRMIGHKPF FPNTPLGTTL QTALVEFIPQ 300
YYLSPLRNGD IPERIVTSEP LEDRLWIQRA LSSGLNRRLA ITDQKRAPYK 350
QWQAMAALNA AQALSQHLAQ KNTFALKLEA IQKSLALPNP IARIECFDIS 400
HTLGEATVAS CVVFGEEGLI KKDYRRFNIS GVTPGDDYGA LRQALTRRYV 450
RLKEGEGILP DVLLIDGGMG QLRQAAEVLE ELQVSGVILT AIAKGPGRKA 500
GLEKLFVWGR REEIHLPADN IAFHLIQQIR DEAHRFAITA HCNRRAKRRV 550
ESTLQEIEGI GPKRRQKLLK YFGGLQELQR ASIEEIARVP GVSETLAKAI 600
YDACHQHKG 609
Length:609
Mass (Da):69,061
Last modified:February 5, 2008 - v1
Checksum:i3617D3FFD3087FD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77103.1.
RefSeqiYP_001424631.1. NC_009727.1.

Genome annotation databases

EnsemblBacteriaiABS77103; ABS77103; CBUD_1276.
GeneIDi5457475.
KEGGicbd:CBUD_1276.
PATRICi17922385. VBICoxBur32972_1287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77103.1 .
RefSeqi YP_001424631.1. NC_009727.1.

3D structure databases

ProteinModelPortali A9KFP2.
SMRi A9KFP2. Positions 552-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434922.CBUD_1276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS77103 ; ABS77103 ; CBUD_1276 .
GeneIDi 5457475.
KEGGi cbd:CBUD_1276.
PATRICi 17922385. VBICoxBur32972_1287.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279961.
KOi K03703.
OMAi QTIASCV.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci CBUR434922:GJTP-1354-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Dugway 5J108-111.

Entry informationi

Entry nameiUVRC_COXBN
AccessioniPrimary (citable) accession number: A9KFP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi