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A9KFP2

- UVRC_COXBN

UniProt

A9KFP2 - UVRC_COXBN

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Protein

UvrABC system protein C

Gene

uvrC

Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciCBUR434922:GJTP-1354-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:CBUD_1276
OrganismiCoxiella burnetii (strain Dugway 5J108-111)
Taxonomic identifieri434922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008555: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609UvrABC system protein CPRO_1000077777Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi434922.CBUD_1276.

Structurei

3D structure databases

ProteinModelPortaliA9KFP2.
SMRiA9KFP2. Positions 552-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278GIY-YIGUniRule annotationAdd
BLAST
Domaini202 – 23736UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279961.
KOiK03703.
OMAiQTIASCV.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9KFP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIDNPSAFL KTLPTGSGVY QIQDAQGKVI YVGKARNLQK RVSSYFRRQL
60 70 80 90 100
DSKTQAMMAQ VQSIQTTITR NENEALLLEA SFIKQFRPRY NVLLRDDKSY
110 120 130 140 150
PYLYLATHQK FPRLDFYRGA KKAPGRYFGP YPNAGSVREN LALIQKLFKL
160 170 180 190 200
RQCSESFFKN RTRPCLQYQI KRCTAPCVGY VNEQEYRRQV EDAILFFEGK
210 220 230 240 250
NDQVIIKLTE RMEVASENLV FEEAAHYRDQ IRQLRRLQKQ QIITGGKGNI
260 270 280 290 300
DIIGIAESNG AIGFAILFIR SGRMIGHKPF FPNTPLGTTL QTALVEFIPQ
310 320 330 340 350
YYLSPLRNGD IPERIVTSEP LEDRLWIQRA LSSGLNRRLA ITDQKRAPYK
360 370 380 390 400
QWQAMAALNA AQALSQHLAQ KNTFALKLEA IQKSLALPNP IARIECFDIS
410 420 430 440 450
HTLGEATVAS CVVFGEEGLI KKDYRRFNIS GVTPGDDYGA LRQALTRRYV
460 470 480 490 500
RLKEGEGILP DVLLIDGGMG QLRQAAEVLE ELQVSGVILT AIAKGPGRKA
510 520 530 540 550
GLEKLFVWGR REEIHLPADN IAFHLIQQIR DEAHRFAITA HCNRRAKRRV
560 570 580 590 600
ESTLQEIEGI GPKRRQKLLK YFGGLQELQR ASIEEIARVP GVSETLAKAI

YDACHQHKG
Length:609
Mass (Da):69,061
Last modified:February 5, 2008 - v1
Checksum:i3617D3FFD3087FD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77103.1.
RefSeqiYP_001424631.1. NC_009727.1.

Genome annotation databases

EnsemblBacteriaiABS77103; ABS77103; CBUD_1276.
GeneIDi5457475.
KEGGicbd:CBUD_1276.
PATRICi17922385. VBICoxBur32972_1287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77103.1 .
RefSeqi YP_001424631.1. NC_009727.1.

3D structure databases

ProteinModelPortali A9KFP2.
SMRi A9KFP2. Positions 552-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434922.CBUD_1276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS77103 ; ABS77103 ; CBUD_1276 .
GeneIDi 5457475.
KEGGi cbd:CBUD_1276.
PATRICi 17922385. VBICoxBur32972_1287.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279961.
KOi K03703.
OMAi QTIASCV.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci CBUR434922:GJTP-1354-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Dugway 5J108-111.

Entry informationi

Entry nameiUVRC_COXBN
AccessioniPrimary (citable) accession number: A9KFP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3