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A9KFP2 (UVRC_COXBN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:CBUD_1276
OrganismCoxiella burnetii (strain Dugway 5J108-111) [Complete proteome] [HAMAP]
Taxonomic identifier434922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length609 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 609609UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000077777

Regions

Domain15 – 9278GIY-YIG
Domain202 – 23736UVR

Sequences

Sequence LengthMass (Da)Tools
A9KFP2 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 3617D3FFD3087FD5

FASTA60969,061
        10         20         30         40         50         60 
MTIDNPSAFL KTLPTGSGVY QIQDAQGKVI YVGKARNLQK RVSSYFRRQL DSKTQAMMAQ 

        70         80         90        100        110        120 
VQSIQTTITR NENEALLLEA SFIKQFRPRY NVLLRDDKSY PYLYLATHQK FPRLDFYRGA 

       130        140        150        160        170        180 
KKAPGRYFGP YPNAGSVREN LALIQKLFKL RQCSESFFKN RTRPCLQYQI KRCTAPCVGY 

       190        200        210        220        230        240 
VNEQEYRRQV EDAILFFEGK NDQVIIKLTE RMEVASENLV FEEAAHYRDQ IRQLRRLQKQ 

       250        260        270        280        290        300 
QIITGGKGNI DIIGIAESNG AIGFAILFIR SGRMIGHKPF FPNTPLGTTL QTALVEFIPQ 

       310        320        330        340        350        360 
YYLSPLRNGD IPERIVTSEP LEDRLWIQRA LSSGLNRRLA ITDQKRAPYK QWQAMAALNA 

       370        380        390        400        410        420 
AQALSQHLAQ KNTFALKLEA IQKSLALPNP IARIECFDIS HTLGEATVAS CVVFGEEGLI 

       430        440        450        460        470        480 
KKDYRRFNIS GVTPGDDYGA LRQALTRRYV RLKEGEGILP DVLLIDGGMG QLRQAAEVLE 

       490        500        510        520        530        540 
ELQVSGVILT AIAKGPGRKA GLEKLFVWGR REEIHLPADN IAFHLIQQIR DEAHRFAITA 

       550        560        570        580        590        600 
HCNRRAKRRV ESTLQEIEGI GPKRRQKLLK YFGGLQELQR ASIEEIARVP GVSETLAKAI 


YDACHQHKG 

« Hide

References

[1]"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Dugway 5J108-111.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000733 Genomic DNA. Translation: ABS77103.1.
RefSeqYP_001424631.1. NC_009727.1.

3D structure databases

ProteinModelPortalA9KFP2.
SMRA9KFP2. Positions 552-601.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING434922.CBUD_1276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS77103; ABS77103; CBUD_1276.
GeneID5457475.
KEGGcbd:CBUD_1276.
PATRIC17922385. VBICoxBur32972_1287.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMAQTIASCV.
OrthoDBEOG6K13R9.

Enzyme and pathway databases

BioCycCBUR434922:GJTP-1354-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_COXBN
AccessionPrimary (citable) accession number: A9KFP2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families