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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei351Proton donorUniRule annotation1
Active sitei382UniRule annotation1
Active sitei509UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:CBUD_0913
OrganismiCoxiella burnetii (strain Dugway 5J108-111)
Taxonomic identifieri434922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000008555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000812361 – 547Glucose-6-phosphate isomeraseAdd BLAST547

Structurei

3D structure databases

ProteinModelPortaliA9KFK2.
SMRiA9KFK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261370.
KOiK01810.
OMAiTNSQHAF.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KFK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVESPPWQ ALKSKYQELS SLHMRDFFAQ DKKRGTRLSL EAAGLYFDYS
60 70 80 90 100
KNRVDEKTID LLCESANACN LPLRIEQLFS GKLTNESGEM VGFHTALRQV
110 120 130 140 150
NNFSFKTNNN AIQEIHASWE KIKKLSIRIR EGDYKGFTNK SITDIVNIGI
160 170 180 190 200
GGSSLGPQMA YNALKPYVKA PLRCHFISNL DDTDFYETVR TLNPETTLFI
210 220 230 240 250
ITSKTFTTKE TLENARRATE WLMQAAKKEN LIQTHFMAVT AAPEKAHEFG
260 270 280 290 300
IQKDNIFMLW PWVGGRFSVW SAAGLSLAIA IGWEEFFEFL RGAHAMDTHF
310 320 330 340 350
RQAEFNKNMP ILLALLSIWY INFFHAKTQA IIPYSQRLVY LPDYLTQLHM
360 370 380 390 400
ESLGKSVQLD GSAVHWQTGA VVWGDLGTNS QHSFHQLFLQ GTMVIPVDFI
410 420 430 440 450
AVLKNSRESH WQLPLIANCL GQSQTLMEGY DKEGVMRDLI NQGIEHEKAE
460 470 480 490 500
KLATYRLIRG NNPSNTIILE ELNPYSLGSL LALYEHKVYV QSVIWNINPF
510 520 530 540
NQWGVERGKH LAKDILQALQ AETDQSSFDS STERLINYVL KIKGNRP
Length:547
Mass (Da):62,326
Last modified:February 5, 2008 - v1
Checksum:i80C2CA3CDA611CA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000733 Genomic DNA. Translation: ABS77556.1.
RefSeqiWP_011996827.1. NC_009727.1.

Genome annotation databases

EnsemblBacteriaiABS77556; ABS77556; CBUD_0913.
GeneIDi31483536.
KEGGicbd:CBUD_0913.

Similar proteinsi

Entry informationi

Entry nameiG6PI_COXBN
AccessioniPrimary (citable) accession number: A9KFK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families