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A9KFA0

- RNC_COXBN

UniProt

A9KFA0 - RNC_COXBN

Protein

Ribonuclease 3

Gene

rnc

Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391MagnesiumUniRule annotation
    Active sitei43 – 431UniRule annotation
    Metal bindingi112 – 1121MagnesiumUniRule annotation
    Active sitei115 – 1151UniRule annotation
    Metal bindingi115 – 1151MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciCBUR434922:GJTP-515-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Short name:
    RNase IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:CBUD_0481
    OrganismiCoxiella burnetii (strain Dugway 5J108-111)
    Taxonomic identifieri434922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008555: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Ribonuclease 3PRO_1000075741Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi434922.CBUD_0481.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KFA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 126123RNase IIIUniRule annotationAdd
    BLAST
    Domaini153 – 22270DRBMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
    Contains 1 RNase III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    HOGENOMiHOG000246809.
    KOiK03685.
    OMAiTFKDQEL.
    OrthoDBiEOG6T1WVS.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KFA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHLNKLMER LGHQFNNLEL LKIALTHRSS GADNNERLEF LGDSVLGFII    50
    ASELYQRRPQ AREGDLSRMR ASMVNGDELA QMSTKLGINE YLQLGVGEQK 100
    SGGKRRRSIL ADALEAIVGA IYIDAGLETC RRCVLNWYGE RVDDLSKLSP 150
    KKDAKSLLQE WLQARRLPLP TYEVKITGEA HAQTFTVNCY VKGLPHKTEG 200
    VNTTRRRAEQ IAAKRFLELL DDGKGDGITE RDQ 233
    Length:233
    Mass (Da):26,252
    Last modified:February 5, 2008 - v1
    Checksum:i477DAB42B5056423
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77753.1.
    RefSeqiYP_001423899.1. NC_009727.1.

    Genome annotation databases

    EnsemblBacteriaiABS77753; ABS77753; CBUD_0481.
    GeneIDi5458473.
    KEGGicbd:CBUD_0481.
    PATRICi17920795. VBICoxBur32972_0518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77753.1 .
    RefSeqi YP_001423899.1. NC_009727.1.

    3D structure databases

    ProteinModelPortali A9KFA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 434922.CBUD_0481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS77753 ; ABS77753 ; CBUD_0481 .
    GeneIDi 5458473.
    KEGGi cbd:CBUD_0481.
    PATRICi 17920795. VBICoxBur32972_0518.

    Phylogenomic databases

    eggNOGi COG0571.
    HOGENOMi HOG000246809.
    KOi K03685.
    OMAi TFKDQEL.
    OrthoDBi EOG6T1WVS.

    Enzyme and pathway databases

    BioCyci CBUR434922:GJTP-515-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
      Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
      Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Dugway 5J108-111.

    Entry informationi

    Entry nameiRNC_COXBN
    AccessioniPrimary (citable) accession number: A9KFA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3