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A9KD33

- EFTU_COXBN

UniProt

A9KD33 - EFTU_COXBN

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Protein
Elongation factor Tu
Gene
tuf1, CBUD_1856
tuf2, CBUD_1870
Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR434922:GJTP-1953-MONOMER.
    CBUR434922:GJTP-1967-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor Tu
    Short name:
    EF-Tu
    Gene namesi
    Name:tuf1
    Ordered Locus Names:CBUD_1856
    AND
    Name:tuf2
    Ordered Locus Names:CBUD_1870
    OrganismiCoxiella burnetii (strain Dugway 5J108-111)
    Taxonomic identifieri434922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008555: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Elongation factor TuUniRule annotation
    PRO_0000337367Add
    BLAST

    Proteomic databases

    PRIDEiA9KD33.

    Interactioni

    Subunit structurei

    Monomer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi434922.CBUD_1870.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KD33.
    SMRiA9KD33. Positions 2-396.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 206197tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1 By similarity
    Regioni60 – 645G2 By similarity
    Regioni81 – 844G3 By similarity
    Regioni136 – 1394G4 By similarity
    Regioni174 – 1763G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGTEMCMP.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9KD33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKEKFVREK PHVNVGTIGH VDHGKTTLTA ALTKVLSEKY GGEKKAFDQI    50
    DNAPEERARG ITIATSHVEY QSDKRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVVSAAD GPMPQTREHI VLAKQVGVPN IVVYLNKADM VDDKELLELV 150
    EMEVRDLLNS YDFPGDETPI IVGSALKALE GDKSEVGEPS IIKLVETMDT 200
    YFPQPERAID KPFLMPIEDV FSISGRGTVV TGRVERGIIK VGDEIEIVGI 250
    KDTTKTTCTG VEMFRKLLDE GQAGDNVGIL LRGTKREEVE RGQVLAKPGS 300
    ITPHKKFEAE IYVLSKEEGG RHTPFLQGYR PQFYFRTTDV TGQLLSLPEG 350
    IEMVMPGDNV KVTVELIAPV AMDEGLRFAV REGGRTVGAG VVTKIIE 397
    Length:397
    Mass (Da):43,526
    Last modified:February 5, 2008 - v1
    Checksum:i8157B2CD749064FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77089.1.
    CP000733 Genomic DNA. Translation: ABS77285.1.
    RefSeqiYP_001425184.1. NC_009727.1.
    YP_001425197.1. NC_009727.1.

    Genome annotation databases

    EnsemblBacteriaiABS77089; ABS77089; CBUD_1856.
    ABS77285; ABS77285; CBUD_1870.
    GeneIDi5457620.
    5457935.
    KEGGicbd:CBUD_1856.
    cbd:CBUD_1870.
    PATRICi17923523. VBICoxBur32972_1848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77089.1 .
    CP000733 Genomic DNA. Translation: ABS77285.1 .
    RefSeqi YP_001425184.1. NC_009727.1.
    YP_001425197.1. NC_009727.1.

    3D structure databases

    ProteinModelPortali A9KD33.
    SMRi A9KD33. Positions 2-396.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 434922.CBUD_1870.

    Proteomic databases

    PRIDEi A9KD33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS77089 ; ABS77089 ; CBUD_1856 .
    ABS77285 ; ABS77285 ; CBUD_1870 .
    GeneIDi 5457620.
    5457935.
    KEGGi cbd:CBUD_1856.
    cbd:CBUD_1870.
    PATRICi 17923523. VBICoxBur32972_1848.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GTEMCMP.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci CBUR434922:GJTP-1953-MONOMER.
    CBUR434922:GJTP-1967-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
      Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
      Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Dugway 5J108-111.

    Entry informationi

    Entry nameiEFTU_COXBN
    AccessioniPrimary (citable) accession number: A9KD33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: September 3, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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