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A9KC20

- GCSPB_COXBN

UniProt

A9KC20 - GCSPB_COXBN

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, CBUD_0293
Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCBUR434922:GJTP-312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:CBUD_0293
OrganismiCoxiella burnetii (strain Dugway 5J108-111)
Taxonomic identifieri434922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000083228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA9KC20.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi434922.CBUD_0293.

Structurei

3D structure databases

ProteinModelPortaliA9KC20.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KC20-1 [UniParc]FASTAAdd to Basket

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MLIFEKSRKN RRTLAHAIAD KMDANDIPAN LLRHDAPRLP ELSELEVVRH    50
FTRLSTQNFS IDTHFYPLGS CTMKYNPRAA NRLASLPGYL KRHPLSPAPQ 100
SQAFLQCLYE LQTMLTEITG MEKISLTSMA GAQGEFAGVA MIKAYHESRG 150
DYDRTEMIVP DAAHGTNPAS AAMCGFTVKE ISTTKDGDID LEKLRQMAGA 200
KTAGIMLTNP STLGVFERQI SEVAKIIHNA GGLLYYDGAN LNAILGKYRP 250
GDMGFDVMHL NLHKTFATPH GGGGPGAGPV AAGPRLSKFL PVPMVGKNKE 300
GYDWLTEKEC PKSIGRLSAF MGNSGVLLRA YIYLRLLGKE GLSRVAEFST 350
LNANYLMKRL EQLGFTLAFP NRRASHEFII TLKPLTRAYG VTALDIAKRL 400
LDYGFHAPTI YFPLLVPECL LIEPTETESK QTLDHFIEAM EKILTEIKTT 450
PDLLRNAPHQ QLINRLDEVK AARELDLRWY PIAKETEIFI Q 491
Length:491
Mass (Da):54,619
Last modified:February 5, 2008 - v1
Checksum:iD7D0E3A1859A98F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS78325.1.
RefSeqiWP_010958389.1. NC_009727.1.
YP_001423715.1. NC_009727.1.

Genome annotation databases

EnsemblBacteriaiABS78325; ABS78325; CBUD_0293.
GeneIDi5458581.
KEGGicbd:CBUD_0293.
PATRICi17920432. VBICoxBur32972_0339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS78325.1 .
RefSeqi WP_010958389.1. NC_009727.1.
YP_001423715.1. NC_009727.1.

3D structure databases

ProteinModelPortali A9KC20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434922.CBUD_0293.

Proteomic databases

PRIDEi A9KC20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS78325 ; ABS78325 ; CBUD_0293 .
GeneIDi 5458581.
KEGGi cbd:CBUD_0293.
PATRICi 17920432. VBICoxBur32972_0339.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CBUR434922:GJTP-312-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Dugway 5J108-111.

Entry informationi

Entry nameiGCSPB_COXBN
AccessioniPrimary (citable) accession number: A9KC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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