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A9KC19

- GCSPA_COXBN

UniProt

A9KC19 - GCSPA_COXBN

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, CBUD_0291
Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCBUR434922:GJTP-311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:CBUD_0291
OrganismiCoxiella burnetii (strain Dugway 5J108-111)
Taxonomic identifieri434922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000083219Add
BLAST

Proteomic databases

PRIDEiA9KC19.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi434922.CBUD_0291.

Structurei

3D structure databases

ProteinModelPortaliA9KC19.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A9KC19-1 [UniParc]FASTAAdd to Basket

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MPFIPHTPDD IEKMLAVIGA ESIDQLFDEI PSALANIQQV PPGLNEAGIT    50
RLMEKREPNK QLCFIGAGAY EHHIPAAVWE IATRGEFYTA YTPYQAEASQ 100
GSLQLIYEYQ TMMAELMAMD VSNASLYDGA SALAEAALMA VRIKRGKAQR 150
ILVPASVNPF YRKVLSSIVE QQKINVEIIP FDPTMGIVNS ELLKAKNAEG 200
AAAIIIPQPN FFGCLEAVDV LTDWAHANDL LVIASVNPTA MALLKPPGQW 250
GQKGADIVCG EGQPLGVPLA SGGPYFGFMC CKKDYVRQLP GRIVGRTVDK 300
KGREGFTLTL QAREQHIRRS KATSNICTNQ GLAVVAATIY LSLLGATGLR 350
EVALASHTQS RDLFQRLSAV KGVSPVFSSP IFHEFVVRLE KPVEEVLAAM 400
AEQGIQAGFS LKNDYPKLGN GLLICVTDTK TDDDLMAYEN ALRSIQ 446
Length:446
Mass (Da):48,465
Last modified:February 5, 2008 - v1
Checksum:iE02EB4C879F0DBB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77062.1.
RefSeqiYP_001423714.1. NC_009727.1.

Genome annotation databases

EnsemblBacteriaiABS77062; ABS77062; CBUD_0291.
GeneIDi5458234.
KEGGicbd:CBUD_0291.
PATRICi17920430. VBICoxBur32972_0338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000733 Genomic DNA. Translation: ABS77062.1 .
RefSeqi YP_001423714.1. NC_009727.1.

3D structure databases

ProteinModelPortali A9KC19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434922.CBUD_0291.

Proteomic databases

PRIDEi A9KC19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS77062 ; ABS77062 ; CBUD_0291 .
GeneIDi 5458234.
KEGGi cbd:CBUD_0291.
PATRICi 17920430. VBICoxBur32972_0338.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CBUR434922:GJTP-311-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Dugway 5J108-111.

Entry informationi

Entry nameiGCSPA_COXBN
AccessioniPrimary (citable) accession number: A9KC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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