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A9KC19

- GCSPA_COXBN

UniProt

A9KC19 - GCSPA_COXBN

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Coxiella burnetii (strain Dugway 5J108-111)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciCBUR434922:GJTP-311-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:CBUD_0291
    OrganismiCoxiella burnetii (strain Dugway 5J108-111)
    Taxonomic identifieri434922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008555: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000083219Add
    BLAST

    Proteomic databases

    PRIDEiA9KC19.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi434922.CBUD_0291.

    Structurei

    3D structure databases

    ProteinModelPortaliA9KC19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9KC19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFIPHTPDD IEKMLAVIGA ESIDQLFDEI PSALANIQQV PPGLNEAGIT    50
    RLMEKREPNK QLCFIGAGAY EHHIPAAVWE IATRGEFYTA YTPYQAEASQ 100
    GSLQLIYEYQ TMMAELMAMD VSNASLYDGA SALAEAALMA VRIKRGKAQR 150
    ILVPASVNPF YRKVLSSIVE QQKINVEIIP FDPTMGIVNS ELLKAKNAEG 200
    AAAIIIPQPN FFGCLEAVDV LTDWAHANDL LVIASVNPTA MALLKPPGQW 250
    GQKGADIVCG EGQPLGVPLA SGGPYFGFMC CKKDYVRQLP GRIVGRTVDK 300
    KGREGFTLTL QAREQHIRRS KATSNICTNQ GLAVVAATIY LSLLGATGLR 350
    EVALASHTQS RDLFQRLSAV KGVSPVFSSP IFHEFVVRLE KPVEEVLAAM 400
    AEQGIQAGFS LKNDYPKLGN GLLICVTDTK TDDDLMAYEN ALRSIQ 446
    Length:446
    Mass (Da):48,465
    Last modified:February 5, 2008 - v1
    Checksum:iE02EB4C879F0DBB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77062.1.
    RefSeqiYP_001423714.1. NC_009727.1.

    Genome annotation databases

    EnsemblBacteriaiABS77062; ABS77062; CBUD_0291.
    GeneIDi5458234.
    KEGGicbd:CBUD_0291.
    PATRICi17920430. VBICoxBur32972_0338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000733 Genomic DNA. Translation: ABS77062.1 .
    RefSeqi YP_001423714.1. NC_009727.1.

    3D structure databases

    ProteinModelPortali A9KC19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 434922.CBUD_0291.

    Proteomic databases

    PRIDEi A9KC19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS77062 ; ABS77062 ; CBUD_0291 .
    GeneIDi 5458234.
    KEGGi cbd:CBUD_0291.
    PATRICi 17920430. VBICoxBur32972_0338.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci CBUR434922:GJTP-311-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
      Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
      Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Dugway 5J108-111.

    Entry informationi

    Entry nameiGCSPA_COXBN
    AccessioniPrimary (citable) accession number: A9KC19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3