A9KBI4 (AHPD_COXBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	CBUD_0522

Organism

Coxiella burnetii (strain Dugway 5J108-111) [Complete proteome] [HAMAP]

Taxonomic identifier

434922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.
Sequence caution	The sequence ABS76918.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359486
Sites
	Active site	133	1	Proton donor By similarity
	Active site	136	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	133 ↔ 136		Alternate By similarity
	Disulfide bond	136		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9KBI4 [UniParc]. Last modified January 20, 2009. Version 3. Checksum: 88F1FEDA6BD68A3B	FASTA	177	19,564
	10 20 30 40 50 60 MLQTYKDQLP DYAKDLKLNL TQVLSESPSS ELSNQQITGV ALAVAYATRN RQLIELIFQK 70 80 90 100 110 120 AEAELDESTL QAIKAAASIM AMNNIYYRFV HLVKDSEYQR LPANLRMNII ANPGIDKKDF 130 140 150 160 170 ELYSLAVSAI NGCGLCIDAH ANTLIKAGFS KHSIQHVIRI AAVLNGLAQV SIIENKT

References

[1]

"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella." Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A. Infect. Immun. 77:642-656(2009) [PubMed: 19047403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Dugway 5J108-111.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000733 Genomic DNA. Translation: ABS76918.2. Different initiation.
RefSeq	YP_001423936.2. NC_009727.1.
3D structure databases
ProteinModelPortal	A9KBI4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9KBI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5457306.
GenomeReviews	Gene locus CBUD_0522 in contig CP000733_GR.
KEGG	cbd:CBUD_0522.
PATRIC	17920867. VBICoxBur32972_0552.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK914808.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_COXBN

Accession

Primary (citable) accession number: A9KBI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	January 20, 2009
Last modified:	January 25, 2012
This is version 35 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program