A9JRC7 (PP4CB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit B
Short name=PP4C-B
EC=3.1.3.16

Gene names

Name:	ppp4cb
ORF Names:	zgc:172126

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein phosphatase that regulates many processes such as microtubule organization at centrosomes By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subunit structure	Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Serine/threonine-protein phosphatase 4 catalytic subunit B		PRO_0000353207
Sites
	Active site	115	1	Proton donor By similarity
	Metal binding	54	1	Iron By similarity
	Metal binding	56	1	Iron By similarity
	Metal binding	82	1	Iron By similarity
	Metal binding	82	1	Manganese By similarity
	Metal binding	114	1	Manganese By similarity
	Metal binding	164	1	Manganese By similarity
	Metal binding	238	1	Manganese By similarity
Amino acid modifications
	Modified residue	307	1	Leucine methyl ester By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9JRC7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: F3162A40BE347E16	FASTA	307	35,097
	10 20 30 40 50 60 MGDMSDLDRQ IDQLRRCELI KENEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY 70 80 90 100 110 120 DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL KVRYPDRITL IRGNHESRQI 130 140 150 160 170 180 TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI 190 200 210 220 230 240 DRKQEVPHDG PMCDLLWSDP EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL 250 260 270 280 290 300 VMEGYKWHFN ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KEFIIFEAAP QETRGIPSKK PVADYFL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC155609 mRNA. Translation: AAI55610.1.
IPI	IPI00503532.
RefSeq	NP_001104638.1. NM_001111168.1.
UniGene	Dr.116008.
3D structure databases
ProteinModelPortal	A9JRC7.
SMR	A9JRC7. Positions 6-307.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000103385.
Proteomic databases
PRIDE	A9JRC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000114857; ENSDARP00000103385; ENSDARG00000076439.
GeneID	562705.
KEGG	dre:562705.
Organism-specific databases
CTD	562705.
ZFIN	ZDB-GENE-080219-32. ppp4cb.
Phylogenomic databases
eggNOG	COG0639.
GeneTree	ENSGT00550000074618.
HOGENOM	HOG000172696.
HOVERGEN	HBG000216.
KO	K15423.
OMA	GFKWHFN.
OrthoDB	EOG4NS3BV.
Gene expression databases
Bgee	A9JRC7.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20884543.

Entry information

Entry name

PP4CB_DANRE

Accession

Primary (citable) accession number: A9JRC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 4, 2008
Last sequence update:	February 5, 2008
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program