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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit B

Gene

ppp4cb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Manganese 1By similarity1
Metal bindingi56Manganese 1By similarity1
Metal bindingi82Manganese 1By similarity1
Metal bindingi82Manganese 2By similarity1
Metal bindingi114Manganese 2By similarity1
Active sitei115Proton donorBy similarity1
Metal bindingi164Manganese 2By similarity1
Metal bindingi238Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • determination of ventral identity Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • positive regulation of BMP signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-5693607. Processing of DNA double-strand break ends.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit B (EC:3.1.3.16)
Short name:
PP4C-B
Gene namesi
Name:ppp4cb
ORF Names:zgc:172126
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-080219-32. ppp4cb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003532071 – 307Serine/threonine-protein phosphatase 4 catalytic subunit BAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA9JRC7.
PeptideAtlasiA9JRC7.
PRIDEiA9JRC7.

Expressioni

Gene expression databases

BgeeiENSDARG00000076439.
ExpressionAtlasiA9JRC7. differential.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103385.

Structurei

3D structure databases

ProteinModelPortaliA9JRC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
InParanoidiA9JRC7.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG091G0B6S.
PhylomeDBiA9JRC7.
TreeFamiTF105559.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9JRC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDMSDLDRQ IDQLRRCELI KENEVKALCA KAREILVEES NVQRVDSPVT
60 70 80 90 100
VCGDIHGQFY DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL
110 120 130 140 150
KVRYPDRITL IRGNHESRQI TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL
160 170 180 190 200
SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI DRKQEVPHDG PMCDLLWSDP
210 220 230 240 250
EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL VMEGYKWHFN
260 270 280 290 300
ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KEFIIFEAAP QETRGIPSKK

PVADYFL
Length:307
Mass (Da):35,097
Last modified:February 5, 2008 - v1
Checksum:iF3162A40BE347E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC155609 mRNA. Translation: AAI55610.1.
RefSeqiNP_001104638.1. NM_001111168.1.
XP_009304674.1. XM_009306399.2.
UniGeneiDr.116008.

Genome annotation databases

EnsembliENSDART00000114857; ENSDARP00000103385; ENSDARG00000076439.
GeneIDi562705.
KEGGidre:562705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC155609 mRNA. Translation: AAI55610.1.
RefSeqiNP_001104638.1. NM_001111168.1.
XP_009304674.1. XM_009306399.2.
UniGeneiDr.116008.

3D structure databases

ProteinModelPortaliA9JRC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103385.

Proteomic databases

PaxDbiA9JRC7.
PeptideAtlasiA9JRC7.
PRIDEiA9JRC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000114857; ENSDARP00000103385; ENSDARG00000076439.
GeneIDi562705.
KEGGidre:562705.

Organism-specific databases

CTDi562705.
ZFINiZDB-GENE-080219-32. ppp4cb.

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
InParanoidiA9JRC7.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG091G0B6S.
PhylomeDBiA9JRC7.
TreeFamiTF105559.

Enzyme and pathway databases

ReactomeiR-DRE-5693607. Processing of DNA double-strand break ends.

Miscellaneous databases

PROiA9JRC7.

Gene expression databases

BgeeiENSDARG00000076439.
ExpressionAtlasiA9JRC7. differential.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP4CB_DANRE
AccessioniPrimary (citable) accession number: A9JRC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.