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A9IZV5

- MDH_BART1

UniProt

A9IZV5 - MDH_BART1

Protein

Malate dehydrogenase

Gene

mdh

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei96 – 961NADUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Active sitei176 – 1761Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi119 – 1213NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBTRI382640:GJEK-2133-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:BT_2679
    OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
    Taxonomic identifieri382640 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000001592: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Malate dehydrogenasePRO_1000081353Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382640.Btr_2679.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IZV5.
    SMRiA9IZV5. Positions 3-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000250283.
    KOiK00024.
    OMAiYAPSAFV.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9IZV5-1 [UniParc]FASTAAdd to Basket

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    MVRKKIALIG SGMIGGTLAH IIGLKELGDV VLFDISEGMP QGKALDIAES    50
    SPIDGFDVHL KGANAYEAIE GADVVIVTAG VARKPGMSRD DLLGINLKVM 100
    EQVGAGIKKY APSAFVICIT NPLDAMVWAL QKFSGLPVHK VVGMAGILDS 150
    ARFRYFLSEE FKVSVKDVTA FVLGGHGDSM VPLVRYSTVG GISLPDLVKM 200
    GWTTQERIDQ IIQRTRDGGA EVISLLKTGS AYYAPAASAV SMAEAYLKGT 250
    KRVVPVAAYL SGEYGVNDTY VGVPVVLGSG GVERVIEIDL DKEERDAFDY 300
    SVNAVKKLCE ACIALVPSLK 320
    Length:320
    Mass (Da):33,998
    Last modified:February 5, 2008 - v1
    Checksum:i70C2D9A043AF03C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK02626.1.
    RefSeqiYP_001610621.1. NC_010161.1.

    Genome annotation databases

    GeneIDi5829603.
    KEGGibtr:Btr_2679.
    PATRICi20553222. VBIBarTri113218_2727.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK02626.1 .
    RefSeqi YP_001610621.1. NC_010161.1.

    3D structure databases

    ProteinModelPortali A9IZV5.
    SMRi A9IZV5. Positions 3-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382640.Btr_2679.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5829603.
    KEGGi btr:Btr_2679.
    PATRICi 20553222. VBIBarTri113218_2727.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000250283.
    KOi K00024.
    OMAi YAPSAFV.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci BTRI382640:GJEK-2133-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
      Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
      Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIP 105476 / IBS 506.

    Entry informationi

    Entry nameiMDH_BART1
    AccessioniPrimary (citable) accession number: A9IZV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3