A9IZV3 (SUCC_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	BT_2678

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella › Bartonella tribocorum

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP-Rule MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP-Rule MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP-Rule MF_00558		PRO_1000082021
Regions
	Domain	9 – 254	246	ATP-grasp
	Nucleotide binding	35 – 118	84	ATP By similarity
Sites
	Metal binding	207	1	Magnesium or manganese By similarity
	Metal binding	209	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IZV3 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: F09ADE863095E8D6	FASTA	398	42,873
	10 20 30 40 50 60 MNIHEYQAKR LLHEYGAPIA NGVAVYSIEQ AEKWAKKLPG PLYVVKSQIH AGGRGKGQFK 70 80 90 100 110 120 ELGPDAKGGV RLAQSVEEVV ANVQEMLGKT LVTKQTGPEG KQVNRLYIED GADIERELYL 130 140 150 160 170 180 SLLVDRSVGR IAFVVSTEGG MDIETVAEET PEKIFTLPID VTEGVTSADC ARLCDALELH 190 200 210 220 230 240 DSAREDGEKL FPILYKAFCE KDMSLLEINP LIVMKDGHLR VLDAKVSFDN NALFRHPDIL 250 260 270 280 290 300 ELRDLSEEDP KEIEASKHDL AYVALEGTIG CMVNGAGLAM ATMDIIKLYG AEPANFLDVG 310 320 330 340 350 360 GGASKEKVTA AFKIITADPN VKGILVNIFG GIMRCDVIAE GVVAAVREVG LKVPLVVRLE 370 380 390 GTNVEQGKAI INDSGLNVIP ADDLDDAAQK IVAAVKGA

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK02625.1.
RefSeq	YP_001610620.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IZV3.
SMR	A9IZV3. Positions 1-395.
ModBase	Search...
Protein-protein interaction databases
STRING	382640.Btr_2678.
Proteomic databases
PRIDE	A9IZV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5829602.
KEGG	btr:Btr_2678.
PATRIC	20553220. VBIBarTri113218_2726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0045.
KO	K01903.
OMA	QPVTKIL.
ProtClustDB	PRK00696.
Enzyme and pathway databases
BioCyc	BTRI382640:GJEK-2132-MONOMER.
UniPathway	UPA00223; UER00999.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 1 hit. 3.40.50.261. 1 hit.
HAMAP	MF_00558. Succ_CoA_beta.
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
PANTHER	PTHR11815. PTHR11815. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001554. SucCS_beta. 1 hit.
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_BART1

Accession

Primary (citable) accession number: A9IZV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program