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A9IZS4 (AROB_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BT_2662
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3773773-dehydroquinate synthase HAMAP MF_00110
PRO_1000094461

Sequences

Sequence LengthMass (Da)Tools
A9IZS4 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: BC20CAE89F0CD001

FASTA37741,424
        10         20         30         40         50         60 
MQAKTVTIKL DKHCYDIIIG PDLIAQAALQ IKHSLKQKNF HQMRLAIVTD TNVASLHLDA 

        70         80         90        100        110        120 
LQAELTKNKI HTFPIIVKAG EQSKSFSTLQ VVIDQILAAR LERGDCVIAF GGGVIGDLAG 

       130        140        150        160        170        180 
FAASMIRRGM NFIQMPTTLL AQIDSSVGGK TGINSRHGKN LIGAFYQPQC VIADTSVLDT 

       190        200        210        220        230        240 
LPPREFRAGY AEMVKYGLIN QPDFFEWLEK NGQKIFSNGA IRIEAIVRSC QFKATIVARD 

       250        260        270        280        290        300 
EYETGERALL NLGHTFGHML ETATAYDSKR LIHGESVAIG MILAHQFSAQ LNLVAPTLIN 

       310        320        330        340        350        360 
RIETHLKAVG LPTQLKDIPG DLPNAETLMA LIAQDKKVSQ NNLTFILSRG LGQSFIAKNV 

       370 
PPDLVLSFLE QKLTEIR

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260525 Genomic DNA. Translation: CAK02609.1.
RefSeqYP_001610604.1. NC_010161.1.

3D structure databases

ProteinModelPortalA9IZS4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9IZS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5829287.
GenomeReviewsGene locus BT_2662 in contig AM260525_GR.
PATRIC20553182. VBIBarTri113218_2707.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBTRI382640:BT_2662-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BART1
AccessionPrimary (citable) accession number: A9IZS4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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