A9IZG7 (ARLY_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BT_2593

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Argininosuccinate lyase HAMAP MF_00006		PRO_1000073837

Sequences

	Sequence		Length	Mass (Da)
	A9IZG7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 078D0F610F5E8C0C	FASTA	466	51,965
	10 20 30 40 50 60 MTDETLKNQM WGGRFIAGPA AVMEEINASI DVDQKLYRQD IEGSLSHAAM LAQTKIILQS 70 80 90 100 110 120 DYEKISHGLK IILQEIEEGD FVFSRNLEDI HMNIEARLSA LIGPVAGRLH TARSRNDQVA 130 140 150 160 170 180 VDFRLWVRET LQKIAQALKQ LIKQLLILAE QHVKTYMPGF THLQLAQPVT LGHYMMAYVE 190 200 210 220 230 240 MFGRDLSRMR DASERMNESP LGAAALAGTS FPIDRFMTAQ ALGFREPTRN SIDSVSDRDF 250 260 270 280 290 300 ALEFLSAGAL CAMHLSRLAE EIILWSSEQF RFIYLSDAFS TGSSIMPQKR NPDAAELVRA 310 320 330 340 350 360 KTGRLNGALM GLLTVMKGLP LAYSKDMQED KEYVFDGALS LELSLAAMTG MIADLEVNKK 370 380 390 400 410 420 AMKQAADLGY ATATDFADWL VRELGIPFRE AHHMTGQAMA LAEKKQCRLQ DLSLDELQAI 430 440 450 460 CPDINATLFD VLTVEKSVES RKSFGGTASS EVLRQIAYWK KRLVSA

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK02545.1.
RefSeq	YP_001610540.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IZG7.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IZG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5830347.
GenomeReviews	Gene locus BT_2593 in contig AM260525_GR.
PATRIC	20553036. VBIBarTri113218_2635.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_2593-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BART1

Accession

Primary (citable) accession number: A9IZG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program