A9IYZ3 (ACSA_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	BT_2482

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000084998
Sites
	Active site	517	1	By similarity
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IYZ3 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 8408FB0F3D9ECAF6	FASTA	647	73,010
	10 20 30 40 50 60 MTEKIYPISE EIKKNTLLDE ETYQKWYRES INDPESFWAK HGQCIEWFKP FTKVKNTSFN 70 80 90 100 110 120 DGVSIQWYED GITNVAYNCI DRHLKTHGDQ IALIWEGDNP YHDKKITYNE LYEHVCRFAN 130 140 150 160 170 180 LLKNHGVKKG DKVTIYLPMI PEAAYAMLAC ARIGAVHSVI FAGFSAEAIA GRIVDCESTF 190 200 210 220 230 240 IITADHGLRG GKRINLKDNV DHAIEIAARQ NVRVDQVMVI RRTCGPIDWI EGRDFWYHEE 250 260 270 280 290 300 ITHAKTNCPA EPMNAEDPLF ILYTSGSTGK PKGVLHSTGG YLVYAAITHK YVFDYHPGEI 310 320 330 340 350 360 YWCTADIGWI TGHSYLVYGP LCNGATTLMF EGTPTFPDKG RFWEIVDKHK VNTLYTAPTA 370 380 390 400 410 420 IRALMGAGNS FVEHSKRTSL RLLGTVGEPI NPEAWEWFYH TVGNDRCPIL DTWWQTETGG 430 440 450 460 470 480 HMITPLPGAT PLKAGSATRP FFGVQLQIID EQGNILEGEA EGNLCIIDSW PGQMRTLYKD 490 500 510 520 530 540 HERFIETYFS TYKGKYFTGD GCRRDSDGYY WITGRVDDIL NVSGHRLGTA EIESALVLHP 550 560 570 580 590 600 AVSEAAVVGY PHPIKGQGVY SFVTLMEGTA PSEELQKDLI KHVRKEIGSI AILDKIQFAP 610 620 630 640 QLPKTRSGKI MRRILRKIAE NNFDNLGDIS TLAEPQVVED LIANRQN

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK02456.1.
RefSeq	YP_001610451.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IYZ3.
SMR	A9IYZ3. Positions 6-646.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IYZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5828978.
GenomeReviews	Gene locus BT_2482 in contig AM260525_GR.
PATRIC	20552810. VBIBarTri113218_2522.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	TRGTEES.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_2482-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_BART1

Accession

Primary (citable) accession number: A9IYZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program